DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and oxi-1

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_499392.1	Gene:	oxi-1 / 176515	WormBaseID:	WBGene00003898	Length:	1066	Species:	Caenorhabditis elegans

Alignment Length:	939	Identity:	214/939 - (22%)
Similarity:	341/939 - (36%)	Gaps:	252/939 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  4315 KIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAIL-GLAEEVR 4378
            ||:.|....|:...|.:      ..|:|  .:|::||     .::.:...|:....| ....|..
Worm   274 KIFEKTLHWLRANAEEI------ETGMD--VRLLINL-----LANLVHFAYINDKTLESKLYEWT 325

  Fly  4379 QAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEG-------- 4435
            .|:.:.|:......:..||..|             :..|...|.|..|||.....||
Worm   326 WAVGVSLSRCTELTVKHGGTKT-------------SLHYWHPVFGHYLLPIDKRTEGALRNVLFQ 377

  Fly  4436 ----------------IMQDRFTAEHVIISAPKNAKPTCELQLPSMKKL---------MSNSSAQ 4475
                            ||::..||...:....||:|..........:||         .|.|.::
Worm   378 LKMLWSSRVVRCLFGNIMENTKTASFSVTDGQKNSKDISAAFSKLWRKLGGSTDSASSSSKSESE 442

  Fly  4476 P----------YFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDI---------EGD 4521
            |          .::..|...:.::.  |..:||       |    .||.::..         |..
Worm   443 PPPTLIAIVCQVYMTALNTMVHMKG--EIISGL-------C----RDDQLLKQLWTYLREWGEKA 494

  Fly  4522 GGASG-----GSSSDMAPGSAS--TISPPPPMETNQIAQDGD---------DDEEDDDEARSFPG 4570
            ||.||     .::....|.|||  ::..|....|..:....|         |:||..::...|
Worm   495 GGTSGSIFNSSNAEQWGPVSASLQSLKRPSSPHTATLRLFVDCAAAIISILDEEEIFEKETPF-- 557

  Fly  4571 VGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRG 4635
             .|..:.|..|..     .|.|...:|:.      |::|:           :.....|.|:.|..
Worm   558 -SNKELESICKYV-----NIFCFRSIWSG------AVDET-----------SANTTGLFHSMHSL 599

  Fly  4636 AS----KKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSSASFDDE 4696
            .:    :.|.|||..|.:.|.|                            :|... |||.:.:.|
Worm   600 LTVLYERDSRRSFAANDSKFWL----------------------------ISEVK-PSSLTIEYE 635

  Fly  4697 PRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAV 4761
            .:             ......|....|.|...:.:.|.|..:.:...|::    .|.|:|
Worm   636 KK-------------SGKGVLMMRKMAHLVPIKDRMLLFRRQVQDDKNRV----ATSLND----- 678

  Fly  4762 LVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIV 4826
                          ...||              .::|:|..:.||.|..|.:|.....|:...:.
Worm   679 --------------PQMQT--------------WITVQRNRIIEDGFNHLSKLTIPALKSTIRVK 715

  Fly  4827 FEDEEGQD-AG----GLLREWYVIISREIFNPMYALF-CVSPGDRVTYMINPSSHANPNHLSYFK 4885
            |.:|:|.| ||    |:.:|:..:..:::|:|...|| ..|.|  |.|. :|:|..:.:||:.|.
Worm   716 FVNEQGLDEAGIDQDGVFKEFLELTLKKVFDPQLNLFSTTSTG--VLYP-SPTSSLHDDHLALFT 777

  Fly  4886 FVGRVIAKAVHDNKLLECYFTRSFYKHILG--KQVKHTDMESQDYEFYKGLDYLMKNDISTLGYE 4948
            ||||::.|||::..:::..........:||  :.....::...|.|.|:.|.::.:.:.......
Worm   778 FVGRMLGKAVYEGIVVDVQLAPVLLAAVLGSHRLCAFDELSQLDPELYRSLTFVKRYEGEMADLS 842

  Fly  4949 LTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPK 5013
            ||||.:....|.....||.|:||..:||.|||.:||..:...::....::|..||:.|...|:..
Worm   843 LTFSVDEDFMGKISTVDLVPSGRTISVTNENKIDYVHRMAHHRVFRRTQEQCKAFVTGMQSILQP 907

  Fly  5014 HLISIFNEQELELLISGL-PDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRS-FDQADRAKFLQ 5075
            ..:|:|...:|:.||||: .|||:.|||.|.:|. .:......|:|.|..|.: |...:|..||:
Worm   908 TWLSLFAPNDLQCLISGVNSDIDLADLKRNVQYFGGFHGNHRLIKWLWDILENKFTSEERKLFLK 972

  Fly  5076 FVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTD-------------------RLPCAHTCFNQ 5121
            |||..|:.|:.||..||....|:..::..|....|                   |||.|.||||.
Worm   973 FVTSCSRPPVLGFSYLEPPFSIRCVEVSDDQDQGDTLGSVVRGFLALRKGTAATRLPTASTCFNL 1037

  Fly  5122 LDLPMYKSYDKLRSCLLKAIHECSEGFGF 5150
            |.||.|.....|...|..|||   .|.||
Worm  1038 LKLPNYNKKSLLLEKLRYAIH---AGTGF 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	117/382 (31%)
		HECTc	4820..5148	CDD:214523	109/357 (31%)
oxi-1	NP_499392.1	HECTc	684..1064	CDD:238033	119/386 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810