Protein Alignment HUWE1 and herc-1

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_490834.1
• Gene: herc-1 / 171700
• WormBaseID: WBGene00021685
• Length: 1019
• Species: Caenorhabditis elegans
• Alignment Length: 991
• Identity: 211/991 - (21%)
• Similarity: 347/991 - (35%)
• Gaps: 245/991 - (24%)

  Fly  4264 EIGDGLAANIEEQASPASGNP----ASGD------SNAGAKRTQLPTLSVALPVTPSKPRRKIYS 4318
            |..||...:..|.....||.|    .:|.      |.:||..|.....|..|.:...:|:..:..
 Worm   171 EQADGRCIHRPEPVEQLSGVPIVRVLAGARHCLALSASGAVFTWGQNNSGELGIDDLRPQTSVQH 235

  Fly  4319 KNFSQLQLVIE---------VLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLA 4374
            .:......|:|         :||| ||.|....:.|     |.||                 |..
 Worm   236 VHQMDGLGVVEAACGDNHTVLLTH-CGRTFSFGSDA-----LGQC-----------------GFG 277

  Fly  4375 EEVRQ-----AIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPN----- 4429
            ::|.:     |:..|:..    ::.:..||.....|...|     |.|...::.:..|.|
 Worm   278 KKVEKRTNPTAVSDLIGS----HVTRIAAGACHTIAICKG-----APYPFGLNSSGQLGNGKIMT 333

  Fly  4430 -------------LAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLP------SMKKLMSNSSAQ 4475
                         ..|..|..|..|......|...:...|:|.:|.|      |:|||:....|.
 Worm   334 QSTPRKTDELDHVTGVFAGYHQTFFVRSSGTIEQNEIVGPSCPMQYPIKLDHESLKKLLDEGDAL 398

  Fly  4476 PYFLRTLKIF-----MQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPG 4535
            ........:|     |.:..:|:.:...:.|.......|.:.|.:::
 Worm   399 EVMSLIESVFSSLASMNMSFLYKDERRYNVGFCFERSHGIDMDQVME------------------ 445

  Fly  4536 SASTISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVL---- 4596
             |..:....||:                  |.:..:...::..|.:.....|..|.||.||
 Worm   446 -AFMLFDEYPMK------------------RQYMELIVDSLKIAFQEWSENLKGIECLRVLLMLP 491

  Fly  4597 WNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKK-----SGRSFMPNAAGFGLRAA 4656
            |..:....|.::..|:     |..|.|:|..||....|.|.:|     |.|.|......|
 Worm   492 WLPIFTENVNVQTIKN-----VHTPFVDAMCLITGDLRAALEKWWTQLSTRHFRRMVTVF----- 546

  Fly  4657 AGAGAIGGLGAAAPSAQEYSPF---MDDVSSAN-----TPSSASFDDEPR--------------M 4699
              ..||..:..|....::...|   |..:|..|     .|....:.||..              .
 Worm   547 --KTAIKAMLKAKKGPRDCHKFILIMQKLSLINKTYHIIPLETFYIDELNTSVDLKLEYVLELTR 609

  Fly  4700 QDAS-------TNTPLVTNPSTSTAMSAHEAQLRQD--RQKFLQFAEKHRTVLNQILRQSPTHLS 4755
            ||.:       |:.|.:.|......:...||.|.|.  ||..| |...|.|::
 Worm   610 QDPNKTELDYWTHFPFLLNGVAKGELIFVEAWLMQTLRRQSSL-FNTAHGTII------------ 661

  Fly  4756 DGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWK 4820
                                    .||..|:         ::|||..:..|:...:..|...:.:
 Worm   662 ------------------------FELPHLE---------LTVRREFIVSDTMNQMAGLSESDLQ 693

  Fly  4821 NRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMIN-PSSHANPNHLSYF 4884
            ....:....|:..||||:.:|:::::.|:|....|.:|.......:.:... ||...:...   |
 Worm   694 KPLKVNIAGEDADDAGGVRKEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPSEFCDREQ---F 755

  Fly  4885 KFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLM---KNDISTLG 4946
            ..:||::..:::::.::...|..:.||::|.......|:........|||..|:   ::|:..:
 Worm   756 HQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDDVEDV- 819

  Fly  4947 YELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLV----CQLKMSGSIRQQLDAFLEGF 5007
            :.|.|.......|.|...:|...|.:..||..|:.|||:|.    .:|..:|.|.||...|.:||
 Worm   820 FGLNFCISFNILGETHTTELLSGGTEKPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGF 884

  Fly  5008 YDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRSFDQADRA 5071
            .:.:....:..|...||:.:|.|..:.|..:.:....|. :|:|....||.||:|..:....:|.
 Worm   885 SESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMYRGEYSSSHPTIQAFWKAFFALTDDERR 949

  Fly  5072 KFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLP-MYKSYDKLRS 5135
            |||||:||::::|:.|:..|..  .||       ..:.:.||.||||||.|||| :....:.||.
 Worm   950 KFLQFLTGSTRIPVSGWEELHA--AIQ-------PSAPESLPVAHTCFNLLDLPNIADDVELLRR 1005

  Fly  5136 CLLKAIHECSEGFGFA 5151
            ..:...|  :|||..|
 Worm  1006 LRISIEH--TEGFTLA 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	95/362 (26%)
herc-1	NP_490834.1	RCC1	7..56	CDD:395335
		ATS1	44..365	CDD:444065	43/225 (19%)
		HECTc	667..1016	CDD:238033	95/372 (26%)