DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and wwp-1

DIOPT Version :10

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_740775.1 Gene:wwp-1 / 171647 WormBaseID:WBGene00007009 Length:794 Species:Caenorhabditis elegans


Alignment Length:627 Identity:196/627 - (31%)
Similarity:284/627 - (45%) Gaps:124/627 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly  4631 ASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSP--------------FMDD 4681
            ::.|.|:.|......|.:.     |||.|.|..| |..|..|:|..|              ::|.
 Worm   182 SARRPATAKRDTLAAPTST-----AAAAAAATAG-GTPAAGAEEQLPDGWEMRFDQYGRKYYVDH 240

  Fly  4682 VSSANT---------PSSASFDDEPRMQ----DASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFL 4733
            .:.:.|         |.......:||.:    |.:|.|.....| |:..:.|||.......|..|
 Worm   241 TTKSTTWERPSTQPLPQGWEMRRDPRGRVYYVDHNTRTTTWQRP-TADMLEAHEQWQSGRDQAML 304

  Fly  4734 QFAEKHRTVLNQILRQSPTHLSDGPFAVLVD-HTRILDFDVKRKYFQTELERL-------DEGIR 4790
            |:.::       .|.|.....:|.|...|.: ..:..|.:..|.||...:.|.       .:|.|
 Worm   305 QWEQR-------FLLQQNNFSADDPLGPLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPRTQGFR 362

  Fly  4791 REEH------------------------------------------------------------- 4794
            ..:.                                                             
 Worm   363 GSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDPRTGKPVGPLGVVGVQMAMEKSFRWKIAQFR 427

  Fly  4795 ------------TVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIIS 4847
                        .::|.|..||||||:.:.|....:.:.|.||.|..|||.|.||:.|||:.::|
 Worm   428 YLCLSNSVPNHVKITVSRNNVFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLS 492

  Fly  4848 REIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKH 4912
            .|:.||||.||..:..:..:..|||:|..||:||.||:::||.||.|:...|.:...||..|||.
 Worm   493 HEVLNPMYCLFMYAGNNNYSLQINPASFVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKK 557

  Fly  4913 ILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTE 4977
            :|.|::...|:|..|.|.|..|.::..|:|.....||.|..:.:..|..:..:||..|.:.||||
 Worm   558 MLNKKIVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTE 622

  Fly  4978 ENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKAN 5042
            |||.||::|:.:.:.:..:.||..||..||..:.|...:..|:|:|||||:.|:.|:|::|.:.|
 Worm   623 ENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRN 687

  Fly  5043 TEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDR 5107
            |.|..|..:|.|:.|||:.:||.||..||:.|||||||.:||:.||..|.|..|.|.|.|.|..:
 Worm   688 TVYRHYAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGK 752

  Fly  5108 STDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            . :.||.:|||||:||||.|:|||:|...|..|| |.:||||
 Worm   753 E-NWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAI-EMTEGFG 792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:428721
DUF913 621..989 CDD:461803
UBA_like_SF 1467..1506 CDD:473871
WWE 1756..1828 CDD:128922
DUF5585 3288..3672 CDD:465521
UBM 3670..3700 CDD:464159
UBM 3719..3746 CDD:464159
HECTc 4796..5149 CDD:238033 151/352 (43%)
wwp-1NP_740775.1 C2 29..147 CDD:472691
WW 221..250 CDD:459800 3/28 (11%)
HUL4 <251..794 CDD:227354 179/552 (32%)
Blue background indicates that the domain is not in the aligned region.

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