DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and Magi1

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_006505643.1 Gene:Magi1 / 14924 MGIID:1203522 Length:1484 Species:Mus musculus


Alignment Length:1540 Identity:262/1540 - (17%)
Similarity:448/1540 - (29%) Gaps:606/1540 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  3567 GTVVSAGTREES------------SAPAVATESTEAVNESNQPEPTPESSESTSP-------NPQ 3612
            ||::..||.|.:            |...:.|::..:: :|...:.||:.::|.:.       :|:
Mouse   174 GTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSL-QSGSKQSTPKRTKSYNDMQNAGIVHPE 237

  Fly  3613 APSAEPTPLEPGAAVDASVGAQTPATTEEAA-STAGASGTTATITDMSPE--------VRAALGD 3668
            ....|..| |..::..|..|.|...|.:||. ....:|...|.|||.|.:        ....||.
Mouse   238 NEEEEDVP-EMNSSFTADSGDQDEHTLQEATLPPVNSSILAAPITDPSQKFPQYLPLSAEDNLGP 301

  Fly  3669 LEVPEGVDPSFLAALPSEMREEVIQEH-------LRMQRIRQRAQQNAIQIAHDSLVEVNPEFLA 3726
            |  ||..:.::     :|..|....:|       |..:.:.:  ||..::...|....|:.|.|.
Mouse   302 L--PENWEMAY-----TENGEVYFIDHNTKTTSWLDPRCLNK--QQKPLEECEDDEEGVHTEELD 357

  Fly  3727 A---LP----------------------LNIQSEVLMQQRIEQQRQAAQTANPEDPVDTAAFFQN 3766
            :   ||                      ...::.||..:|.:|..|..|...|:.|         
Mouse   358 SELELPAGWEKIEDPVYGVYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQPQPP--------- 413

  Fly  3767 LPENLRQAILTDMEESQIASLPPELAAEAQFLRRDWESRNGARMDAHPPSNALSRFQTTLQSLDD 3831
            .||        :..|...:.:||.                   ..:||||               
Mouse   414 QPE--------EWTEDHASVVPPV-------------------APSHPPS--------------- 436

  Fly  3832 TRWHSSIWYDASGNAQPQHHQHTTIVHQHPHAHHAPNMGKPLALLMMEDENILLDPDSLATLLLF 3896
                         |.:|              |...|..|||                       |
Mouse   437 -------------NPEP--------------ARETPLQGKP-----------------------F 451

  Fly  3897 LFVEDQKVNSMRLHRVIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQAGG-KP-EWLKLR 3959
            ......::....:|..:|                        :.:..||....|| :| |:|:::
Mouse   452 FTRNPSELKGKFIHTKLR------------------------KSSRGFGFTVVGGDEPDEFLQIK 492

  Fly  3960 VDAAFGYKSNIFLINRLYEGSARSISINPQA------AQMI-------VRNCLDLLFVLAKHYPS 4011
            .....|..:   |..::..|.. .:|:|...      ||::       :...:||  .|.:.|| 
Mouse   493 SLVLDGPAA---LDGKMETGDV-IVSVNDTCVLGHTHAQVVKIFQSIPIGASVDL--ELCRGYP- 550

  Fly  4012 SFVPFNRDVKARRILSAVFGMPSPTAGSGGGAGSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQV 4076
              :||:.|.....::::|                                 ..||      :..:
Mouse   551 --LPFDPDDPNTSLVTSV---------------------------------AILD------KEPI 574

  Fly  4077 VNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSVPYQTNAKNFWDVVL 4141
            :...:..:|.        |...:..|.|.::.|.|..:..:...|.:.|..|..|.:     :..
Mouse   575 IVNGQETYDS--------PASHSSKTGKVSSMKDARPSSPADVASNSSHGYPNDTVS-----LAS 626

  Fly  4142 NIDQQTQVRLANVAQFPLTSQPAWEWQPNTADF-LSFSESP--FGQLLEMLPYKVICRSPHLTDM 4203
            :|..|.::...::.:.|:             .| .:.::||  .||.::.:.....||.....|:
Mouse   627 SIATQPELITVHIVKGPM-------------GFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDL 678

  Fly  4204 LVKL------------LASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPA 4256
            :|::            :..:..|.||..|:..|            |||.|.      |.|.:.|.
Mouse   679 IVEVNKKNVQALTHNQVVDMLIECPKGSEVTLL------------VQRGGL------PVPKKSPK 725

  Fly  4257 ENTATATEIGDGLAANIEEQASPASGNPASG-----------------DSNAGAKR-------TQ 4297
            .......:..:....::....|..:.:|:.|                 ..::|.|:       .|
Mouse   726 SQPLERKDSQNSSQHSVSSHRSLHTASPSHGIQVLPEYLPADAPAPDQTDSSGQKKPDPFKIWAQ 790

  Fly  4298 LPTLSVALPVTPS--------KPRRKIYSKNFSQLQL----VIEVLTHQCGTTEGLDNVAKLIVN 4350
            ..::....|::||        :..|:|.|.||.:.|:    ..::...:..|..|.        .
Mouse   791 SRSMYENRPMSPSPASGLSKGERDREINSTNFGECQIPDYQEQDIFLWRKETGFGF--------R 847

  Fly  4351 LTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATA 4415
            :...::....|:|.::..  ||                               ||.|.|...:..
Mouse   848 ILGGNEPGEPIYIGHIVP--LG-------------------------------AADTDGRLRSGD 879

  Fly  4416 SYVPTVSGASLL---PNLAVHEGIMQDRFTAEHVIISAPKN---AKPTCELQLPSMKKLMSNSSA 4474
            ..: .|.|..::   ..|.|.  :||......||.::..:.   |.|..|.::||... ..:||.
Mouse   880 ELI-CVDGTPVIGKSHQLVVQ--LMQQAAKQGHVNLTVRRKVVFAVPKAENEVPSPAS-SHHSSN 940

  Fly  4475 QPYFLRTLKIFMQVRDMYEAQNGLST---GGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGS 4536
            ||..|...|     |....:||.|:|   |.|...|.|         .|.||.||..|:.:.|..
Mouse   941 QPASLTEEK-----RTPQGSQNSLNTVSSGSGSTSGIG---------SGGGGGSGVVSAVLQPYD 991

  Fly  4537 ---------------ASTISPPP-------------PMETNQIAQDGDDDEEDDDEARSFPGVGN 4573
                           .|::|.|.             |.:..:|.:....|.....:      ||:
Mouse   992 VEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLK------VGD 1050

  Fly  4574 H--AVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGA 4636
            .  ||...|.:.|.....:..:....||::..::..:||.:. .:|.....:......||..:..
Mouse  1051 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNA-TLLTNAEKIATITTTHAPSQQG 1114

  Fly  4637 SKKSGRSFMP--------------------------NAAGFGLRAAAG----------------- 4658
            ::::..:..|                          .|.|||.....|                 
Mouse  1115 TQETRTTTKPKQDSQFEFKGPQAAQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGP 1179

  Fly  4659 --------------------------AGAI-----GG------LGAAAPSAQEYSPFMDDVSSAN 4686
                                      :.||     ||      |.....|..||.|..|    .|
Mouse  1180 AERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLRRGDGSVPEYDPSSD----RN 1240

  Fly  4687 TPSSASF----------DDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKH-- 4739
            .||:.:.          |..|.....|:..|.:...|......||....:.:|:...|..|.|  
Mouse  1241 GPSTGAQGVPEVRPGPPDHRPHPALESSYPPELHKSSQHAEKRAHAKDPKGNREHSKQPNEHHTW 1305

  Fly  4740 ----------------------------RTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDV--- 4773
                                        ||..|...|:||....:|        ||..|..:   
Mouse  1306 NGTSRKQDSGACRPKDRPPDAWREAQPERTATNGSKRRSPEKRREG--------TRSADNTLERR 1362

  Fly  4774 ----KRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRL 4814
                ||:....|.:|.....||::.:.|.||        |.|.||
Mouse  1363 EKHEKRREISPERKRERSPTRRKDSSPSRRR--------RSLERL 1399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 18/95 (19%)
DUF4414 3675..3779 CDD:291075 22/135 (16%)
HECTc 4796..5149 CDD:238033 7/19 (37%)
HECTc 4820..5148 CDD:214523
Magi1XP_006505643.1 PDZ_signaling 15..100 CDD:238492
GuKc 122..293 CDD:214504 27/120 (23%)
WW 302..331 CDD:366073 7/35 (20%)
WW 362..393 CDD:197736 2/30 (7%)
PDZ 462..548 CDD:214570 19/115 (17%)
PDZ 633..716 CDD:214570 18/107 (17%)
MAGI_u5 715..798 CDD:374709 10/88 (11%)
PDZ_signaling 840..915 CDD:238492 18/118 (15%)
PDZ_signaling 989..1084 CDD:238492 15/100 (15%)
PDZ 1145..1227 CDD:214570 10/81 (12%)
PRK12678 1203..>1452 CDD:237171 47/217 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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