DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and Trip12

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	XP_011236956.1	Gene:	Trip12 / 14897	MGIID:	1309481	Length:	2074	Species:	Mus musculus

Alignment Length:	2313	Identity:	461/2313 - (19%)
Similarity:	739/2313 - (31%)	Gaps:	729/2313 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  3175 PHLIKELKAAHQQRKQEEAARQSTTPASGSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSA 3239
            ||...:.:...|:::.:.|...||:.|....:.|..||...     ....|.|       :.|.:
Mouse   149 PHSKSKKRHLDQEQQLKSAQLPSTSKAHTRKSVAAGSSRNQ-----KRKRTES-------SCVKS 201

  Fly  3240 GSGSSSLVVPPVAASATGGTRRSSIPVLIS-----------STLGPSSASSATSATGNGATSDAT 3293
            ||||.|          ||...||:.|:.::           ||:..||::::||::.:...|.::
Mouse   202 GSGSES----------TGAEERSAKPIKLASKSATSAKAGCSTITDSSSAASTSSSSSAIASASS 256

  Fly  3294 TTTGGPTRNFSSVDSNVSSETQTTTRP-PRQRGGLRQQSQL----PFNIYA----EIDLTNEQDS 3349
            |...| .|.....|.|.:..:::.:.| ||:....::||:.    .|:..|    ::.|...:.|
Mouse   257 TVPAG-ARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLS 320

  Fly  3350 EGDRSTSTTTGTAADGAESQSQHNSSSTAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELL 3414
            ....|.|.|:.....|.:::......||      .:....||..|         |..|
Mouse   321 LPGSSKSETSKPGPSGLQAKLASLRKST------KKRSESPPAEL---------PSLR------- 363

  Fly  3415 LLQLTDRQIRNRLQGSSGHTNSSRTSGSALINARPNRDLPACLQRHDHPAGSIFPRPSANRTPAP 3479
                  |..|.:..||...| |.|.||.....|...|       |.:
Mouse   364 ------RSTRQKTTGSCAST-SRRGSGLGKRGAAEAR-------RQE------------------ 396

  Fly  3480 TLVSMPTPMSNAALEQLNVTAPDVVRTDRNFALPSSLEVDVDVLPGIVDLPQQEAQPEDDQL--- 3541
               .|..|.||.  |.:|.:|   .|||.   .|........|...:......|::.:|.::
Mouse   397 ---KMADPESNQ--ETVNSSA---ARTDE---APQGAAASSSVAGAVGMTTSGESESDDSEMGRL 450

  Fly  3542 -LLPPPPPPPPSDTTPLVHAEDDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTPE--- 3602
             .|......||....||......|:..|:.|..    ||......:..:|.:||.|.:...|
Mouse   451 QALLEARGLPPHLFGPLGPRMSQLFHRTIGSGA----SSKAQQLLQGLQASDESQQLQAVIEMCQ 511

  Fly  3603 ----SSESTSPNPQAPSAEP---TPLEPGAAVDASVGAQTPATTEEAASTAGASGTTATITDMSP 3660
                .:|.|.......|..|   |.|:    ::.:......|.............::|.:.|..|
Mouse   512 LLVMGNEETLGGFPVKSVVPALITLLQ----MEHNFDIMNHACRALTYMMEALPRSSAVVVDAIP 572

  Fly  3661 EVRAALGDLEVPEGVDPSFLAALPSEM-----REEVIQEH------LRMQRIRQRAQQNAIQIAH 3714
               ..|..|:|.:.:|.:..|....||     .:.::|..      |.::.....||:||:.||.
Mouse   573 ---VFLEKLQVIQCIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAA 634

  Fly  3715 DSLVEVNPE---FLA-ALPLNIQSEVLMQQRIEQQRQAAQTANPEDPVDTAAFFQNL------PE 3769
            :....:.|:   |:| :|||      |.|:...|.:::.::        |...|..|      .|
Mouse   635 NCCQSITPDEFHFVADSLPL------LTQRLTHQDKKSVES--------TCLCFARLVDNFQHEE 685

  Fly  3770 NLRQAI-----LTDMEESQIASLP---------------------PELAAEAQFLRRDWE----- 3803
            ||.|.:     ||::::..:.:.|                     |.||  .|.:::.:.
Mouse   686 NLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTLA--VQLMKQSFTDIAET 748

  Fly  3804 -------SRNGA---RMDAHP--------------------PSNALSRFQTTL-----QSLDDTR 3833
                   :.||:   ::|..|                    |...:....|.|     |:.|...
Mouse   749 LHFLLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAI 813

  Fly  3834 WHSSIWYDASGNAQPQHHQHTTIVHQHPHAHHAPNMGKPLALLMMEDENILLDPDSLATLLLFLF 3898
            |.   |.|..|...|.:...:.|:....|     .:|        |||      .||:||.....
Mouse   814 WQ---WRDDRGLWHPYNRIDSRIIEVAAH-----QVG--------EDE------ISLSTLGRVYT 856

  Fly  3899 VEDQKVNSMRLHRVIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAA 3963
            ::   .|||                           |:.|||.....|.|.  ||..|.
Mouse   857 ID---FNSM---------------------------QQINEDTGTARAIQR--KPNPLA------ 883

  Fly  3964 FGYKSNIFLINRLYEGSARS--ISINPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNRDVKARRIL 4026
               .||....:.|.:..||:  :..:|:.|:..::.   |..||.:.|.||..|..|....|.||
Mouse   884 ---NSNTSGYSELKKDDARAQLMKEDPELAKSFIKT---LFGVLYEVYSSSAGPAVRHKCLRAIL 942

  Fly  4027 SAVFGMPSPTAGS--GGGAGSGSAASGGLTGYDDVPPGGTLD------------FRSRFCRYQVV 4077
            ..::...:.....  ...|.|...|| .|:..|.....|.|.            |...|.|..|:
Mouse   943 RIIYFADAELLKDVLKNHAVSSHIAS-MLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGVM 1006

  Fly  4078 NRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSVPYQTNAKNFWDVVLN 4142
            ::::.:               |.|.|...:...|.|....:.||....|....|.|.|
Mouse  1007 HQVKHL---------------AESESLLTSPPKACTNGSGSLGSTTPASSGTATAATN------- 1049

  Fly  4143 IDQQTQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKL 4207
                        |...|.|......:.::.|.     ||.|:|.::|..|
Mouse  1050 ------------ASADLGSPSLQHSRDDSLDL-----SPQGRLSDVLKRK--------------- 1082

  Fly  4208 LASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATATEIGDGLAAN 4272
                  .|||.                      |.......||......:|.|.:........::
Mouse  1083 ------RLPKR----------------------GPRRPKYSPPRDDDKVDNQAKSPTTTQSPKSS 1119

  Fly  4273 IEEQASPASGNPASGDSNAG----AKRTQLPTLS-VALPVTPSKPRRKI---------------- 4316
            .....:|.:....|..||:.    |:...:..|: .|...|.|..|.||
Mouse  1120 FLASLNPKTWGRLSAQSNSNNIEPARTAGVSGLARAASKDTISNNREKIKGWIKEQAHKFVERYF 1184

  Fly  4317 YSKNFSQLQLVIEVLTHQCGTTEGL----DNVAKLIVNLTQCSQAS--SAIFIQ----------Y 4365
            .|:|.......:.||...|..||.|    |..|:.:|.:......|  |:..||          |
Mouse  1185 SSENMDGSNPALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLY 1249

  Fly  4366 LT----------------------------------------AAILGLAEEVRQAI-QMLLNEIR 4389
            ||                                        |.:|.|..::...: ||....::
Mouse  1250 LTSKNEKDAVGREIRLKRFLHVFFSSPLPGEEPVGRVEPVGHAPLLALVHKMNNCLSQMEQFPVK 1314

  Fly  4390 MYNIHQG-GAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKN 4453
            :::...| |||                            .:.:::.|....:|...|.:
Mouse  1315 VHDFPSGNGAG----------------------------GSFSLNRGSQALKFFNTHQL------ 1345

  Fly  4454 AKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDI 4518
               .|:||.......:......|..:..|.: :|..:.|....|:...|.|.....|:|||..|.
Mouse  1346 ---KCQLQRHPDCANVKQWKGGPVKIDPLAL-VQAIERYLVVRGIFRYGRVREDDEDSDDDGSDE 1406

  Fly  4519 EGDGGASGG--SSSDMAPGSASTISP---PPPMETNQI-----AQDGDDDEEDDDEARSFPGVG- 4572
            |.|...:..  :|.::.......|..   |..|...|.     .|..|:.|..|||:......|
Mouse  1407 EIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSVQAEDERESTDDESNPLGRAGI 1471

  Fly  4573 ---NHA-----VASASKSTKPTLSQILCL----------------------DVLW---------N 4598
               .|.     |....:|||.      |:                      |.||         |
Mouse  1472 WTKTHTIWYKPVREDEESTKD------CVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVAN 1530

  Fly  4599 TLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIG 4663
            .|...|:........|.    .|:::...|:...|  |..:.......||
Mouse  1531 PLEVYLIPTPPENITFE----DPSLDVILLLRVLH--AISRYWYYLYDNA--------------- 1574

  Fly  4664 GLGAAAPSAQEYSPFMDDVSSANTPSSASFDDEPRMQD----ASTNTPLVTNPSTSTAMSAHEAQ 4724
                   ..:|..|..:.::|..|..:     ..::||    .:.|.|........|........
Mouse  1575 -------MCKEIIPTSEFINSKLTAKA-----NRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFD 1627

  Fly  4725 LRQ--------DRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTE 4781
            .||        ||.:.:|                                |:||.:.:.....::
Mouse  1628 TRQMLFYVTAFDRDRAMQ--------------------------------RLLDTNPEINQSDSQ 1660

  Fly  4782 LERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVII 4846
            ..|:...:.|::.||:  |..:.:.:..|:..||..  :....|.:|:|.|...|..| |:|.::
Mouse  1661 DSRVAPRLDRKKRTVN--REELLKQAESVMQDLGSS--RAMLEIQYENEVGTGLGPTL-EFYALV 1720

  Fly  4847 SREIFNPMYALFCVSPGDRVTYMINPSSH---------------------ANPNHLS----YFKF 4886
            |:|:   ..|..|:..|:.|| :.||...                     |.|.|::    .|:|
Mouse  1721 SQEL---QRADLCLWRGEEVT-LSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRF 1781

  Fly  4887 VGRVIAKAVHDNKLLECYFTRSFYKHIL------------------GKQVKHTD--------MES 4925
            :|:::|||:.|.:|::......|||.:|                  .:.|.|.:        :|.
Mouse  1782 LGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQ 1846

  Fly  4926 QDYEFYKGLDYLMKN------DISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYV 4984
            ...:..:.|.|.::.      .:..||.:.|..      |...| :||..|:|..||..|..||:
Mouse  1847 DKSQTKESLQYALETLTMNGCSVEDLGLDFTLP------GFPNI-ELKKGGKDIPVTIHNLEEYL 1904

  Fly  4985 QLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEY---- 5045
            :||....::..:.:|.|:|.:||..:.|...:..|..:||:.|:.| ...|..|.|...|.
Mouse  1905 RLVIFWALNEGVCRQFDSFRDGFESVFPLCHLQYFYPEELDQLLCG-SKADTWDAKTLMECCRPD 1968

  Fly  5046 HKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTD 5110
            |.||..|..:::.:..|.|||...:..|||||||:.::|:.||.||.....|.:......:...|
Mouse  1969 HGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDD 2033

  Fly  5111 RLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            .||...||.|.|.||.|.|.|.:|..||.|..|..:.|
Mouse  2034 FLPSVMTCVNYLKLPDYSSIDIMRDKLLIAAREGQQSF 2071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740	14/85 (16%)
		DUF4414	3675..3779	CDD:291075	30/129 (23%)
		HECTc	4796..5149	CDD:238033	112/414 (27%)
		HECTc	4820..5148	CDD:214523	106/388 (27%)
Trip12	XP_011236956.1	SRP1	489..>714	CDD:227396	49/245 (20%)
		WWE	814..876	CDD:397111	23/113 (20%)
		HECTc	1672..2072	CDD:238033	113/417 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900