DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and HECTD2

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_001271203.2	Gene:	HECTD2 / 143279	HGNCID:	26736	Length:	780	Species:	Homo sapiens

Alignment Length:	831	Identity:	205/831 - (24%)
Similarity:	330/831 - (39%)	Gaps:	163/831 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  4393 IHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAK-- 4455
            |...|||.|  |....||....:::...:|..|.....|      ::|.:..|::....||.:
Human    37 IVSAGAGAT--AGLDRGAKGQISTFSSFISAVSPKKEAA------ENRSSPAHLVFPNIKNVREP 93

  Fly  4456 -PTC----ELQLPSMKKLMSNSSA----------QPYFLRTLKIFMQVRDMYEAQNGLSTGGGVA 4505
             |.|    :.|..||....|...|          ||   :|:|.|.:
Human    94 PPICLDVRQKQRTSMDASSSEMKAPVLPEPILPIQP---KTVKDFQE------------------ 137

  Fly  4506 CGAGDNDDDIIDIEGDGGASGG---SSSDMAPGSASTISPPPPMETNQIAQDGDD---------- 4557
                  |.:.:...||..|...   ::.|..|...:..........|.|...|.:
Human   138 ------DVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTIEDSGINAKFVNAVYDT 196

  Fly  4558 --DEEDDDEARSFPGVGNHAVAS-ASKSTKPTLSQ--ILCLDVLWNTLSECLVALEESKDEFAVL 4617
              :...|.:.....|:.|..:.. ....||..|..  ||..:..:|..|..::        :|.|
Human   197 LLNTPQDVQKTVLKGIINSLLREWKGPRTKDDLRAYFILLQNPQFNNTSTYVI--------YAHL 253

  Fly  4618 VLQ--PTVEA--FFLIH---ASHRGASKKSGRSFMPNAAGF-GLRAAAGAGAIGGLGAAAPSAQE 4674
            :.|  ..|||  .||:|   ..:...|:|..:..:.....| .||          |..|.|  :|
Human   254 LRQIATLVEADHHFLVHWFKKQYSRLSQKRFKQLVERLLQFISLR----------LFPAKP--EE 306

  Fly  4675 YSPFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSA-HEAQLRQDRQKFLQFAEK 4738
            :.|...  .|...||:|.........:...:.||:  |.|....|. ....|.::...:..|...
Human   307 FPPITK--CSWWIPSAAKVLALLNTANNLVHPPLI--PYTDFYNSTLDHIDLMEEYHTWQNFGNS 367

  Fly  4739 HRTVLNQILRQSPTHLSDGPFAVLVDHTR-ILDFDVKRKYFQTELERLDEGIRREEH-------- 4794
            ||....|.           ||.:.|...: |:..|.:::......:.|.:.:.|.:.
Human   368 HRFSFCQY-----------PFVISVAAKKIIIQRDSEQQMINIARQSLVDKVSRRQRPDMNILFL 421

  Fly  4795 TVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFC 4859
            .:.|||..:..||...|.| ...:.|.:..:.|..|.|.|.|||.:||::::.|:||:|.|.:|
Human   422 NMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMF- 484

  Fly  4860 VSPGDRVTYMINPSSHAN------PNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQV 4918
                   ||  :..||.:      .::.|.|:.||.::..||:::..|:..|....||.:|...:
Human   485 -------TY--HKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPI 540

  Fly  4919 KHTD---------MESQDY-----EFYKGLDYLMKNDIST-LGYELTFSTEVQEFGVTQIRDLKP 4968
            ..:|         :...|.     |...||..|:.::.:. ..:..||....:|||:.:..:|||
Human   541 IPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKP 605

  Fly  4969 NGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPD 5033
            .|...:||.:|:.|||||.....::.||.:|..||..||:.:...:.:.:...:|:|:|:.|.||
Human   606 GGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPD 670

  Fly  5034 IDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQ 5098
            :|:..|:.:|:|..|......|::||..:..|....:.|.|.|.||:.:||:.|...|
Human   671 LDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADL------- 728

  Fly  5099 KFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            .|:|.:::.||:.||.||||||||.||.|||...|:..|:..|.. |||||
Human   729 NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISN-SEGFG 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	117/373 (31%)
		HECTc	4820..5148	CDD:214523	109/348 (31%)
HECTD2	NP_001271203.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		5/10 (50%)
HECTD2	NP_001271203.2	HECTc	421..778	CDD:238033	117/375 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810