Protein Alignment HUWE1 and HECTD2

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: XP_047280612.1
• Gene: HECTD2 / 143279
• HGNCID: 26736
• Length: 781
• Species: Homo sapiens
• Alignment Length: 836
• Identity: 207/836 - (24%)
• Similarity: 332/836 - (39%)
• Gaps: 172/836 - (20%)

  Fly  4393 IHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAK-- 4455
            |...|||.|  |....||....:::...:|..|.....|      ::|.:..|::....||.:
Human    37 IVSAGAGAT--AGLDRGAKGQISTFSSFISAVSPKKEAA------ENRSSPAHLVFPNIKNVREP 93

  Fly  4456 -PTC----ELQLPSMKKLMSNSSA----------QPYFLRTLKIFMQVRDMYEAQNGLSTGGGVA 4505
             |.|    :.|..||....|...|          ||   :|:|.|.:
Human    94 PPICLDVRQKQRTSMDASSSEMKAPVLPEPILPIQP---KTVKDFQE------------------ 137

  Fly  4506 CGAGDNDDDIIDIEGDGGASGG---SSSDMAPGSASTISPPPPMETNQIAQDGDD---------- 4557
                  |.:.:...||..|...   ::.|..|...:..........|.|...|.:
Human   138 ------DVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTIEDSGINAKFVNAVYDT 196

  Fly  4558 --DEEDDDEARSFPGVGNHAVAS-ASKSTKPTLSQ--ILCLDVLWNTLSECLVALEESKDEFAVL 4617
              :...|.:.....|:.|..:.. ....||..|..  ||..:..:|..|..::        :|.|
Human   197 LLNTPQDVQKTVLKGIINSLLREWKGPRTKDDLRAYFILLQNPQFNNTSTYVI--------YAHL 253

  Fly  4618 VLQ--PTVEA--FFLIHASHRGASKKSGRSFMPNAAGF-GLRAAAGAGAIGGLGAAAPSAQEYSP 4677
            :.|  ..|||  .||:| ..:..|:|..:..:.....| .||          |..|.|  :|:.|
Human   254 LRQIATLVEADHHFLVH-WFKKLSQKRFKQLVERLLQFISLR----------LFPAKP--EEFPP 305

  Fly  4678 FMDDVSSANTPSSAS--------FDDEPRMQDASTNTPLVTNPSTSTAMSA-HEAQLRQDRQKFL 4733
            ...  .|...||:|.        |.|   ..:...:.||:  |.|....|. ....|.::...:.
Human   306 ITK--CSWWIPSAAKVLALLKFIFTD---TANNLVHPPLI--PYTDFYNSTLDHIDLMEEYHTWQ 363

  Fly  4734 QFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTR-ILDFDVKRKYFQTELERLDEGIRREEH--- 4794
            .|...||....|.           ||.:.|...: |:..|.:::......:.|.:.:.|.:.
Human   364 NFGNSHRFSFCQY-----------PFVISVAAKKIIIQRDSEQQMINIARQSLVDKVSRRQRPDM 417

  Fly  4795 -----TVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPM 4854
                 .:.|||..:..||...|.| ...:.|.:..:.|..|.|.|.|||.:||::::.|:||:|.
Human   418 NILFLNMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 481

  Fly  4855 YALFCVSPGDRVTYMINPSSHAN------PNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHI 4913
            |.:|        ||  :..||.:      .::.|.|:.||.::..||:::..|:..|....||.:
Human   482 YGMF--------TY--HKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 536

  Fly  4914 LGKQVKHTD---------MESQDY-----EFYKGLDYLMKNDIST-LGYELTFSTEVQEFGVTQI 4963
            |...:..:|         :...|.     |...||..|:.::.:. ..:..||....:|||:.:.
Human   537 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKS 601

  Fly  4964 RDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLI 5028
            .:|||.|...:||.:|:.|||||.....::.||.:|..||..||:.:...:.:.:...:|:|:|:
Human   602 YNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILV 666

  Fly  5029 SGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEG 5093
            .|.||:|:..|:.:|:|..|......|::||..:..|....:.|.|.|.||:.:||:.|...|
Human   667 CGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADL-- 729

  Fly  5094 MNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
                 .|:|.:::.||:.||.||||||||.||.|||...|:..|:..|.. |||||
Human   730 -----NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISN-SEGFG 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	117/373 (31%)
HECTD2	XP_047280612.1	HECTc	422..779	CDD:238033	117/375 (31%)