DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HUWE1 and Ube3b

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_473434.2	Gene:	Ube3b / 117146	MGIID:	1891295	Length:	1070	Species:	Mus musculus

Alignment Length:	467	Identity:	147/467 - (31%)
Similarity:	219/467 - (46%)	Gaps:	61/467 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  4725 LRQDRQKFLQFAE--KHRTVLNQILRQSPTHLSDGPFAVLVDH-TRILDFDVKRKYFQTELERLD 4786
            ||:|.:..:.|.|  |.|.....:|:..| |        :|.| .|:|.|   |.....|.|:|.
Mouse   619 LRRDLKPGVLFQELDKDRRRAQLVLQHIP-H--------VVPHKNRVLLF---RNMVIKEKEKLG 671

  Fly  4787 --EGIRREEHT--VSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVF-----EDEEGQDAGGLLREW 4842
              |......|.  :::||..:.||.:..|.:|.....|....:.|     .||.|.|..|:.:|:
Mouse   672 LVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEF 736

  Fly  4843 YVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTR 4907
            ...|.:.:|:|...||..:.||...|. :|:|:.:.|:|..|:|||:::.|||::..:::..|..
Mouse   737 LEEIIKRVFDPALNLFKTTSGDERLYP-SPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFAS 800

  Fly  4908 SFYKHILGKQVKHT-------DMESQDYEFYKGLDYLMK--NDISTLGYELTFSTEVQEFGVTQI 4963
            .|...:||..  |:       ::.|.|.||||.|..:.:  .||:.||..|::..:|  .|....
Mouse   801 FFLSQMLGHH--HSVFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDV--MGQLVC 861

  Fly  4964 RDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLI 5028
            .:|.|.|:...||:|||..|:.|:...:|...|:.|..|.:.||..||....|.:|:..||:.||
Mouse   862 HELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLI 926

  Fly  5029 SG-LPDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRS-FDQADRAKFLQFVTGTSKVPLQGFGS 5090
            || ..:||:||||.:|.|: .:......|.|.|..|.| |...:||.||:|||..|:.||.||..
Mouse   927 SGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAY 991

  Fly  5091 LEGMNGIQKFQIHRDDRSTD-------------------RLPCAHTCFNQLDLPMYKSYDKLRSC 5136
            |:....|:..::..|..:.|                   |||.:.||||.|.||.|.....||..
Mouse   992 LKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREK 1056

  Fly  5137 LLKAIHECSEGF 5148
            |..|| ..:.||
Mouse  1057 LRYAI-SMNTGF 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	126/389 (32%)
		HECTc	4820..5148	CDD:214523	118/363 (33%)
Ube3b	NP_473434.2	HECTc	684..1068	CDD:238033	126/390 (32%)
Ube3b	NP_473434.2	HECTc	709..1067	CDD:214523	118/363 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810