DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and Magi2

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_446073.2 Gene:Magi2 / 113970 RGDID:621855 Length:1277 Species:Rattus norvegicus


Alignment Length:1188 Identity:210/1188 - (17%)
Similarity:349/1188 - (29%) Gaps:461/1188 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  3218 GTAAPTATSSIASGLLANAVSAGSGSSSLVVPPVAASATGGTRRS-SIPVLISSTLGP--SSASS 3279
            ||..|.|.   .:.||.|.       :..::|....||.|..:|: |:..:..:::.|  .....
  Rat   184 GTPKPPAE---PAPLLLNV-------TDQILPGATPSAEGKRKRNKSVTNMEKASIEPPEEEEEE 238

  Fly  3280 ATSATGNGATSDATTTTGGPTRNFSSVDSNVSSETQTTTRPPRQRGGLRQQSQLPFNIYAEIDLT 3344
            .....|||......::        ...|.:..:..:|.::|            .|..:|::.:..
  Rat   239 RPVVNGNGVVITPESS--------EHEDKSAGASGETPSQP------------YPAPVYSQPEEL 283

  Fly  3345 NEQDSEGDRSTSTTTGTAAD-------------GAESQSQHNSSSTAAQVAVPQHQRHPPVPLLP 3396
            .:| .:..:||.......:|             |......||:.:|:.              |.|
  Rat   284 KDQ-MDDTKSTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSW--------------LDP 333

  Fly  3397 SSGRPSRPHTRLDETELLLLQLTDRQIRNRLQGS--SGHTNSSRTSGSALINARPNRDLPACLQR 3459
            ...:.::|.....|.|   |.....:|.:.:.|:  ..|.|......:.::.|:..      ||:
  Rat   334 RLAKKAKPAEECKENE---LPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRK------LQQ 389

  Fly  3460 HDHPAGSIFPRPSANRTPAP-----------------TLVSMPTPMSNAAL-----------EQL 3496
            |:.|...:..:|    ..||                 |.:|.....||...           |.|
  Rat   390 HNMPHTELGTKP----LQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFL 450

  Fly  3497 NV--------------------------------TAPDVVRTDRNFALPSSLEVDVDVLPGIVDL 3529
            .|                                |..|||:..::..:..|:.:   ||.....|
  Rat   451 QVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNL---VLCRGYPL 512

  Fly  3530 PQQEAQPEDDQLLLPPP------PPPPPSDTTPLVHAEDDLWPGTVVSAGTREESSAPAVATEST 3588
            |   ..|||....:.||      |||                  .:|:.....|:....::..|.
  Rat   513 P---FDPEDPANSMVPPLAIMERPPP------------------VMVNGRHNYETYLEYISRTSQ 556

  Fly  3589 EAVNESNQPEPTPESSESTSPNPQAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGTTA 3653
            ...:.:::|   |.|..|...:.|.....|.|:.......||.|| |.|.........||.|...
  Rat   557 SVPDITDRP---PHSLHSMPADGQLDGTYPPPVHDDNVSVASSGA-TQAELMTLTIVKGAQGFGF 617

  Fly  3654 TITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQIAHDSLV 3718
            ||.| ||..:.....|::         ...|.....::|.|         ..|||...::|..:|
  Rat   618 TIAD-SPTGQRVKQILDI---------QGCPGLCEGDLIVE---------INQQNVQNLSHTEVV 663

  Fly  3719 EVNPEFLAALPLNIQSEVL---------------MQQRIEQQRQAAQTANPEDPVDTAAFFQNL- 3767
            ::    |...|:..::.::               |..|.|.|      .:|:..:...|..|:| 
  Rat   664 DI----LKDCPVGSETSLIIHRGGFFSPWKTPKPMVDRWENQ------GSPQTSLSAPAVPQSLP 718

  Fly  3768 -PENLRQAILTDMEESQIASLPP--ELAAEAQFL---RRDWESRNGARMDAHPPSNALSRFQTTL 3826
             |..|.::...|..|:.....|.  ||..:::.:   |:....|...|||:..|.         .
  Rat   719 FPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPD---------Y 774

  Fly  3827 QSLDD--TRWHSSIWYDASGNAQPQHHQHTTIVHQHPHAHHAPNMGKPL---ALLMM--EDENIL 3884
            :.||.  .|..|...:...|..:|                     |:|:   |::.|  .|.:..
  Rat   775 KELDVHLRRMESGFGFRILGGDEP---------------------GQPILIGAVIAMGSADRDGR 818

  Fly  3885 LDP-DSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQ 3948
            |.| |.|      ::|:...| :.:.||.:.:|.||                             
  Rat   819 LHPGDEL------VYVDGIPV-AGKTHRYVIDLMHH----------------------------- 847

  Fly  3949 AGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSISINPQAAQMIVRNCLDLLFVLAKHYPSSF 4013
                                           :||:..:|     :.||                 
  Rat   848 -------------------------------AARNGQVN-----LTVR----------------- 859

  Fly  4014 VPFNRDVKARRILSAVFGMPSPTAGSGGGAGSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQVVN 4078
                     |::|..  |.|.|..|...|:.|...:|.                ||.:..|...|
  Rat   860 ---------RKVLCG--GEPCPENGRSPGSVSTHHSSP----------------RSDYATYANSN 897

  Fly  4079 RLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSVPYQTNAKNFWDVVLNI 4143
                    |.||           :|.|:..:..|:           ||:  ||:     ||:::.
  Rat   898 --------HAAP-----------SSNASPPEGFAS-----------HSL--QTS-----DVIIHR 925

  Fly  4144 DQQTQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLP------YKV--------- 4193
            .:........::........|....|:          ..|::::..|      .||         
  Rat   926 KENEGFGFVIISSLNRPESGATITVPH----------KIGRIIDGSPADRCAKLKVGDRILAVNG 980

  Fly  4194 --ICRSPHLTDMLVKLL--ASLS--------------TELPKEEELLPLSDQMPPLV----PIGP 4236
              |...||..  :|||:  |.||              |..|..|:..|::.|..||.    |:..
  Rat   981 QSIINMPHAD--IVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQHSPLAQQHSPLAQ 1043

  Fly  4237 VQRAGAAAAAAHPPPPQP 4254
            ...|...:..|.|.||||
  Rat  1044 PSPATPNSPVAQPAPPQP 1061

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 17/75 (23%)
DUF4414 3675..3779 CDD:291075 20/120 (17%)
HECTc 4796..5149 CDD:238033
HECTc 4820..5148 CDD:214523
Magi2NP_446073.2 PDZ_signaling 22..96 CDD:238492
GuKc 118..291 CDD:214504 23/137 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..308 19/123 (15%)
Interaction with DDN. /evidence=ECO:0000250 302..381 15/95 (16%)
WW 304..333 CDD:395320 5/42 (12%)
WW 350..381 CDD:197736 5/30 (17%)
PDZ 428..509 CDD:214570 12/83 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..575 4/21 (19%)
PDZ 602..683 CDD:214570 19/103 (18%)
MAGI_u5 687..758 CDD:406953 16/76 (21%)
PDZ 775..861 CDD:214570 27/204 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 869..913 14/78 (18%)
PDZ_signaling 920..1007 CDD:238492 17/98 (17%)
PRK10263 <1007..>1135 CDD:236669 15/55 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1011..1130 15/51 (29%)
PDZ_signaling 1140..1220 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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