DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and WWP1

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_008944.1 Gene:WWP1 / 11059 HGNCID:17004 Length:922 Species:Homo sapiens


Alignment Length:1006 Identity:276/1006 - (27%)
Similarity:437/1006 - (43%) Gaps:223/1006 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  4280 ASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVL-------THQCGT 4337
            |:.:|.|..||..:.|.||     .:.|:.:|.:||   ||:....:..||:       |.:..:
Human     2 ATASPRSDTSNNHSGRLQL-----QVTVSSAKLKRK---KNWFGTAIYTEVVVDGEITKTAKSSS 58

  Fly  4338 TEGLDNVAKLIVNLTQCSQASSAIFI-QYLTA-AILGLA---------------EEVRQAIQMLL 4385
            :.......:|.||:|..:.....::. :.|.| |:||.|               |.|::.:::.|
Human    59 SSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSL 123

  Fly  4386 NE------------------IRMYNI------------------HQGG---AGTTSQAA--STSG 4409
            ..                  |...||                  |:.|   |.||::.|  .|:|
Human   124 ENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNG 188

  Fly  4410 AAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISA-PKNAKPTCELQLPSMKKLMSNSS 4473
                ..::|||   ::|:.|......:..|...:....::| |||.        |:.|.|.|..:
Human   189 ----IDNHVPT---STLVQNSCCSYVVNGDNTPSSPSQVAARPKNT--------PAPKPLASEPA 238

  Fly  4474 AQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSAS 4538
            .                  :..||.|:.......|......::..|          :.::|...|
Human   239 D------------------DTVNGESSSFAPTDNASVTGTPVVSEE----------NALSPNCTS 275

  Fly  4539 TISPPPPMETNQIAQDGDDDE-------EDDDEARSF--PGVGNHAVAS---ASKSTKPTLSQIL 4591
            |....||::  :|....:::|       |.:.||||.  |...|...:|   |:||.:|.    .
Human   276 TTVEDPPVQ--EILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPD----G 334

  Fly  4592 CLDVL----WNTLSECLVA-LEESKDEFAVLVLQPTVEAFFLIH--------------------- 4630
            |:|.:    .|..:|.|.: .|:.||        |....:::.|                     
Human   335 CMDPVRQQSGNANTETLPSGWEQRKD--------PHGRTYYVDHNTRTTTWERPQPLPPGWERRV 391

  Fly  4631 --------ASHRGASKKSGRSFMPNAAGF--------GLRAAAGAGAIGGLGAAAPSAQEYSPF- 4678
                    ..|...:....|..|.:...|        .|:.|........|.:|:..|.|..|: 
Human   392 DDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYG 456

  Fly  4679 ------------MDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQK 4731
                        .|.|...|..:..:..::||.|......||           ....::|..|:.
Human   457 PLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEEPL-----------PEGWEIRYTREG 510

  Fly  4732 FLQFAEKH-RTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQ--TELERLDEGIRREE 4793
            ...|.:.: ||...:..|...:.::.|...:..:.    .|..|..:|:  .:...|...::   
Human   511 VRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYER----GFRWKLAHFRYLCQSNALPSHVK--- 568

  Fly  4794 HTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALF 4858
              ::|.|.|:|||||:.:..|.|.:.:.|.|::|..|||.|.|||.|||:.::|.|:.||||.||
Human   569 --INVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLF 631

  Fly  4859 CVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDM 4923
            ..:..:.....|||:|..||:|||||.|:||.||.|:...|.::..|:..|||.:|.|::...|:
Human   632 EYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDL 696

  Fly  4924 ESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVC 4988
            ||.|.|||..|.::..|:|...|.|:.||.:::..|.....|||..|.:..||||||.||:.|:.
Human   697 ESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMT 761

  Fly  4989 QLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSA 5053
            :.:.|..:::|..|||:||.:::|...:..|:|:|||:::.|:.::|:.|.:.||.|..||..|.
Human   762 EWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSK 826

  Fly  5054 QIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTC 5118
            ||.|||:.::..|...|.:.|||||||.::||.||..|.|.||.|||.|.:..:.| .||.:|||
Human   827 QIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT-WLPRSHTC 890

  Fly  5119 FNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            ||:||||.||||::|:..||.||.| :||||
Human   891 FNRLDLPPYKSYEQLKEKLLFAIEE-TEGFG 920

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 155/352 (44%)
HECTc 4820..5148 CDD:214523 144/327 (44%)
WWP1NP_008944.1 C2_E3_ubiquitin_ligase 17..140 CDD:175988 25/130 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..388 43/227 (19%)
HUL4 <307..922 CDD:227354 207/648 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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