DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HUWE1 and Ube3c

DIOPT Version :9

Sequence 1:	NP_001285288.1	Gene:	HUWE1 / 32510	FlyBaseID:	FBgn0030674	Length:	5151	Species:	Drosophila melanogaster
Sequence 2:	NP_598668.1	Gene:	Ube3c / 100763	MGIID:	2140998	Length:	1083	Species:	Mus musculus

Alignment Length:	429	Identity:	134/429 - (31%)
Similarity:	217/429 - (50%)	Gaps:	45/429 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  4747 LRQSPTHLS-DGPFAVLVDHTRILDFDVKRKYFQ-----TELERLDEGIRREEHTVSVRRVTVFE 4805
            |...|..:| :...|:|.:...::.|:.:.|.||     .:.|...:|...:...|::||..::|
Mouse   670 LESLPLSVSEERQLAILTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYE 734

  Fly  4806 DSFRVLYRLGPE---EWKNRFYIVF-----EDEEGQDAGGLLREWYVIISREIFNPMYALFCVSP 4862
            |::.   :|.||   :.|.|..:..     .||.|.|.||:.||:...:.:..|||....| .:.
Mouse   735 DAYD---KLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFF-KTT 795

  Fly  4863 GDRVTYMINPSSH--ANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGK----QVKHT 4921
            .:.:.|. ||::.  ...:...::.|:||::.||:::|.|:|..|...|...:||.    .:.|
Mouse   796 NEGLLYP-NPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHH- 858

  Fly  4922 DMESQDYEFYKGLDYL--MKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYV 4984
             :.|.|.|.|:.|.:|  .:.|:..||  |.|:....:.|..|:.:||..|:|..||..|:..|:
Mouse   859 -LASLDPEVYRNLLFLKSYEEDVEELG--LNFTVVNNDLGEAQVVELKFGGKDIPVTGANRIAYI 920

  Fly  4985 QLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISG--LPDIDIEDLKANTEYH- 5046
            .||...:::..||....||.:|..:::....:.:|::||:::||||  :| :.:||||:.|.|.
Mouse   921 HLVADYRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVP-VSLEDLKSFTNYSG 984

  Fly  5047 KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDR 5111
            .|::....|:.|||.:..|...::.|.|:|||..|:.||.||..|     ...|.||......:|
Mouse   985 GYSADHPVIKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKEL-----YPAFCIHNGGSDLER 1044

  Fly  5112 LPCAHTCFNQLDLPMYKSYDK--LRSCLLKAIHECSEGF 5148
            ||.|.||.|.|.||.:  ||:  |||.||.|| ||:.||
Mouse  1045 LPTASTCMNLLKLPEF--YDEALLRSKLLYAI-ECAAGF 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642
		UBA_like_SF	1467..1506	CDD:304366
		WWE	1756..1828	CDD:128922
		40S_SA_C	3575..3651	CDD:292740
		DUF4414	3675..3779	CDD:291075
		HECTc	4796..5149	CDD:238033	123/374 (33%)
		HECTc	4820..5148	CDD:214523	113/345 (33%)
Ube3c	NP_598668.1	Cis-determinant of acceptor ubiquitin-binding. /evidence=ECO:0000250	1..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..386
		HECTc	723..1081	CDD:238033	123/376 (33%)
		HECTc	747..1080	CDD:214523	113/347 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810