DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and hecw2a

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_009302976.1 Gene:hecw2a / 100150269 ZFINID:ZDB-GENE-090311-22 Length:1475 Species:Danio rerio


Alignment Length:1286 Identity:301/1286 - (23%)
Similarity:469/1286 - (36%) Gaps:349/1286 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  4033 PSPTAGSGGGA-GSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDDHPAPKPSVPL 4096
            |||||..|... |.||:    :...|....|||||                              
Zfish   368 PSPTASLGSNRNGEGSS----IPSPDTEIYGGTLD------------------------------ 398

  Fly  4097 DEAPST------------SKAAAAKAAATAKVSTAGSQNKHSVPYQTNAKNFWDVVLNIDQQ--- 4146
            |||||:            ....|.|......:..|..:.:.|.|..|..    ..:|:||..   
Zfish   399 DEAPSSPDLLQGSFSEQLDAIEAPKGPGDRPLGAASPKLRSSFPTHTRL----SAMLHIDSDEDE 459

  Fly  4147 -----TQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVK 4206
                 |:..|:.....|.:.|...:.....|.|....|.|                         
Zfish   460 DRSAATEATLSTFNGIPRSYQTPPKAAARGAVFDGGIEEP------------------------- 499

  Fly  4207 LLASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATATEIGDGLA- 4270
               |....|..|.|.|...:::||...:.|...|.....|:.....:..........|..:||| 
Zfish   500 ---SEEAGLESEVETLNAGEEVPPEPEVVPSSVAPEVETASLMERQEEQGREVEVEEEEEEGLAR 561

  Fly  4271 -------ANIEEQASPASGNPASGDSNA--GAKRTQLP---TLSVALPVT------------PSK 4311
                   .:|...||.....|||....|  ||:....|   .||...|.|            .::
Zfish   562 SEELATEVDISSMASDCCPGPASASQEAEQGAEAAIDPGGEDLSDDPPTTYEVAETAEETHLTNE 626

  Fly  4312 PRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEE 4376
            |.|                   :....|...|..:...::|:.:.:.     ::...|..|:::|
Zfish   627 PER-------------------EAPKPEPPTNEEEECEDVTEDTMSR-----RWSLEATAGVSQE 667

  Fly  4377 VRQAIQMLLNEIRMYNIHQG-GAGTTSQAASTSGAAAATASY--VPTVSGASLLPNLAVHEGIMQ 4438
            ....:           |..| |....|:...|.     |.|.  ||.|:|...:.:|   ..:.|
Zfish   668 DEDEL-----------IPSGDGESVDSETFVTE-----TESELGVPQVNGDQRVNSL---PSVRQ 713

  Fly  4439 DRFTAEHVIISAPKNAKPTCELQLPSMKKLM--------------SNSSAQPYFLRTLKIFM--Q 4487
            |....:.|....|    |..|.::.|..::.              :...|.....|:..|..  |
Zfish   714 DIHRYQRVDEPLP----PNWEARIDSHGRIFFVDHVNRTTTWQRPTGPPAPQGLTRSSSILQMEQ 774

  Fly  4488 VRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQIA 4552
            :...|::.....|                           |.....|    .:..||..||:.:|
Zfish   775 LNRRYQSIRRTMT---------------------------SERSEEP----RVEDPPADETDVLA 808

  Fly  4553 QDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVL 4617
            |...:...|        |:...   |:|:|....|.|......|            .|.|.|:||
Zfish   809 QSISEYRRD--------GIIGQ---SSSRSRLALLLQSPGAKFL------------SSPDFFSVL 850

  Fly  4618 VLQPTVEAFF-----LIH--------ASH-------------------------RGASKK---SG 4641
            ...|:....|     |.|        |.|                         ||...|   :|
Zfish   851 HSNPSAYRMFTSNTCLKHMISKVRRDAQHFERYQHNRDLVNFLNLFSNKQLELPRGWEMKHDHTG 915

  Fly  4642 RSF-----------------MPNAAGFGLRA---------AAGAGAIGGLGAAAPS------AQE 4674
            ::|                 :.|:...||.|         :..||.:|. .:.:||      :..
Zfish   916 KAFFVDHNCRATTFIDPRLPLQNSRSSGLLAHRQHLSRQRSHSAGEVGD-DSRSPSPPVQGRSSR 979

  Fly  4675 YSPFMDDVSSANTPSSASFDDEP--------------------------RMQDASTNTPLVTNPS 4713
            .|.:.|.|..|......:|..:|                          |.:.|:..|.|.::..
Zfish   980 NSQYQDLVPVAYNDKIVAFLRQPNIFEILQERQPELVRNHSLREKVQFIRNEGATGLTRLSSDAD 1044

  Fly  4714 TSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFA---VLVDHTRILDFDVKR 4775
            ....:|..|       ::.:.:...:..:|:.....||......|.|   ....:.|  ||:.|.
Zfish  1045 LVMLLSLFE-------EEVMSYVPPNALLLSSYCHASPQSSPGTPRANARAPAPYKR--DFEAKL 1100

  Fly  4776 KYFQTELERLDEGIRREEHTVSVRRVTVFEDSF-RVLYRLGPEEWKNRFYIVFEDEEGQDAGGLL 4839
            :.|..::|....|....:..:.:||..:.||:| :::.....:..::|.|:.|..|||.|..|..
Zfish  1101 RNFYRKMETKGYGQGPGKVKLIIRRDHLLEDAFNQIMCYSRKDLQRSRLYVSFVGEEGLDYSGPS 1165

  Fly  4840 REWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECY 4904
            ||::.::|||:|||.|.||..|..|..|..|:|.|....||..:|:|.||::..|:....||:.:
Zfish  1166 REFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAF 1230

  Fly  4905 FTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPN 4969
            |||.|||.:|......:|:|..|.||::.|.::..|||..: .:|||:...:.||....|:|||.
Zfish  1231 FTRPFYKGLLRIPCDLSDLEFLDEEFHQSLQWMKDNDIEDM-LDLTFTVNEEVFGQITERELKPG 1294

  Fly  4970 GRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDI 5034
            |...||:::||.||::.:.:.::...:.||.::.:.|||:::...|:|:|:.:||||:|:|..:|
Zfish  1295 GSGIAVSDKNKKEYIERMVKWRIERGVAQQTESLVRGFYEVVDVRLVSVFDARELELVIAGTAEI 1359

  Fly  5035 DIEDLKANTEYH-KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQ 5098
            |:.|.:.||||. .|......|:|||.|:..|:...|.:.||||||||.:|.:||.||.|.||.:
Zfish  1360 DLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPR 1424

  Fly  5099 KFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            :|.:.:..:.|. ||.||||||:||||.|.|:..|...::.|:.|.|. ||
Zfish  1425 RFCVEKWGKVTS-LPRAHTCFNRLDLPPYPSFSMLYEKMVTAVEETST-FG 1473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 136/354 (38%)
HECTc 4820..5148 CDD:214523 131/328 (40%)
hecw2aXP_009302976.1 HECW_N 50..169 CDD:318711
C2_NEDL1-like 188..323 CDD:176073
WW 724..756 CDD:197736 4/35 (11%)
WW 903..934 CDD:197736 5/30 (17%)
HECTc 1120..1473 CDD:238033 136/355 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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