DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and herc5.4

DIOPT Version :9

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_005160166.1 Gene:herc5.4 / 100148091 ZFINID:ZDB-GENE-090311-7 Length:995 Species:Danio rerio


Alignment Length:439 Identity:103/439 - (23%)
Similarity:185/439 - (42%) Gaps:61/439 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly  4724 QLRQDRQKFLQFAEKH-RTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDE 4787
            |:.:|....::..|.: |||                 .:||......||..|::.|....|....
Zfish   596 QINEDFHDMVKLEEYYFRTV-----------------KILVKFPFASDFITKQRMFNLLQEECFR 643

  Fly  4788 GI------RREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVII 4846
            .:      ....:.:.:.|.:|..|:.:.| |.....:.:...:.|..|:|.|..||..|::.:|
Zfish   644 NVPNLAMGNSFSNLLHINRESVLTDTLQYL-RQNTHSFMHPLQVAFIGEDGIDMRGLSAEFFSLI 707

  Fly  4847 SREIFNPMYALFCVSPGDRVTYMINPSSHA--NPNHL---SYFKFVGRVIAKAVHDNKLLECYFT 4906
            |:....          .|:....::.||..  ||:|.   ..|.::|.:...|:::...:...|.
Zfish   708 SKSFIE----------WDKKILEVHESSLVWFNPHHTRGNKNFYYLGVICGMALYNRHHINIDFP 762

  Fly  4907 RSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKND---ISTLGYELTFSTEVQEFGVTQIRDLKP 4968
            .:.:|.:|.::....|:|.......:.|..|::.|   :..|.: |.|:.:.||        |.|
Zfish   763 LALFKKLLQQKPSLDDLEELSPVEARSLKNLLEEDEEEVVNLQH-LDFTCKGQE--------LVP 818

  Fly  4969 NGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPD 5033
            ||....|.:.|:.:||.|...|:.:.|::.|.:.|..||....|....::|:.:||:.|:.|.|.
Zfish   819 NGSQIQVNKVNRQKYVDLYVDLEFNKSVKTQFEQFTRGFSKGCPLDAWTMFHPEELQELLHGSPQ 883

  Fly  5034 IDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQ 5098
            .:.::|:.:..|...::....|:.||.......:.::.|||.|:.||.:||..|...       :
Zfish   884 YNWKELQQSASYEGCSASDELIKNFWTVFFELSEENKKKFLMFLYGTERVPAGGLSK-------R 941

  Fly  5099 KFQIHRDD--RSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECS 5145
            ..:|.:.|  ...|.||.|.|||.:|.||.|...:.|...|:.||:.|:
Zfish   942 ALKISQTDCPDPDDHLPEAQTCFERLVLPKYSDINTLHDKLIHAINSCA 990

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740
DUF4414 3675..3779 CDD:291075
HECTc 4796..5149 CDD:238033 90/360 (25%)
HECTc 4820..5148 CDD:214523 85/336 (25%)
herc5.4XP_005160166.1 RCC1_2 117..146 CDD:290274
RCC1 133..183 CDD:278826
RCC1 186..235 CDD:278826
RCC1 239..286 CDD:278826
RCC1 294..343 CDD:278826
HECTc 658..993 CDD:294058 90/360 (25%)
HECTc 682..992 CDD:214523 85/335 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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