DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9281 and HEF3

DIOPT Version :9

Sequence 1:	NP_001285284.1	Gene:	CG9281 / 32508	FlyBaseID:	FBgn0030672	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_014384.3	Gene:	HEF3 / 855718	SGDID:	S000004959	Length:	1044	Species:	Saccharomyces cerevisiae

Alignment Length:	746	Identity:	192/746 - (25%)
Similarity:	280/746 - (37%)	Gaps:	269/746 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ANGVPERELTEE---------------EKLCAKLEEEARISAEARSCTGSLAVHPRSRDVK---- 75
            ||.:.||.:.::               ||...::.::.|     :....::.|.|..:|.:
Yeast   370 ANLIDERIIDQQTWFTHVTPYMTIFLHEKTAKEILDDFR-----KRAVDNIPVGPNFQDEEDEGE 429

  Fly    76 -IAN--FSITFFGSELLQDTMLELNCGRRYGLIGLNGCGKSSLL-AVLGG-----------REVP 125
             :.|  ||:.:....||..|.|.|..||||||.|.||.|||:|: ::..|           |.|.
Yeast   430 DLCNCEFSLAYGAKILLNKTQLRLKRGRRYGLCGPNGAGKSTLMRSIANGQVDGFPTQDECRTVY 494

  Fly   126 VPPHIDIFHLTREIPASSKSALQCVM--EVDEERIKLEKLAEELAMSEEDDAQEQLIDIYERLDD 188
            |...||..|       |..|.|..|.  .|..:.:...||.|
Yeast   495 VEHDIDNTH-------SDMSVLDFVYSGNVGTKDVITSKLKE----------------------- 529

  Fly   189 MSADLAEVKAARILHGLGFDKAMQQKQAKDFSGGWRMRIALARALFVKPHLLLLDEPTNHLDLDA 253
                            .||...|.:......||||:|::|||||:.....:|||||||||||...
Yeast   530 ----------------FGFSDEMIEMPIASLSGGWKMKLALARAVLKDADILLLDEPTNHLDTVN 578

  Fly   254 CVWLEEELKTYKRILVLISHSQDFLNGVCTNIIHLTGKRLKYYTGNYEAFVRTRMELLENQMKQY 318
            ..||...|.|.....|::||...||:.||..|||..|.:|:.|.||...||:
Yeast   579 VEWLVNYLNTCGITSVIVSHDSGFLDKVCQYIIHYEGLKLRKYKGNLSEFVQ------------- 630

  Fly   319 NWEQDQISHMKNYIARFGHGSAKLARQAQSKEKTLAKMVAQGLTEKVSDDKVLNFYFPSCGKV-- 381
                                          |..|     ||...|..:.|  |.|.||:.|.:
Yeast   631 ------------------------------KCPT-----AQSYYELGASD--LEFQFPTPGYLEG 658

  Fly   382 ----PPPVIMVQNVNFRYNDETPWIYKNLEFGIDLDTRLALVGPNGAGKSTLLKLLYGDLVPTSG 442
                ...::.|.|:.|:|...|.....::.|...|.:|:|::||||||||||:.:|.|:|:||||
Yeast   659 VKTKQKAIVKVSNMTFQYPGTTKPQVSDVTFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSG 723

  Fly   443 MIRKNSHLRIARYHQH--LHELLDLDASPLEY-------------MMRAFPDVKEK--EEMRKII 490
            .:..:.:.|||...||  .|....||.:|.||             |.||...:.|.  |.|.||.
Yeast   724 EVYTHENCRIAYIKQHAFAHIESHLDKTPSEYIQWRFQTGEDRETMDRANRQINENDAEAMNKIF 788

  Fly   491 ----------------------------------------------------------------- 490

Yeast   789 KIEGTPRRVAGIHSRRKFKNTYEYECSFLLGENIGMKSERWVPMMSVDNAWLPRGELIESHSKMV 853

  Fly   491 -----------GRYGLTGRQQV---CP-------------IRQLSDGQRCRVVFAWLAWQVPHLL 528
                       |::....|:::   |.             ||.||.||:.::|.|...||.|||:
Yeast   854 AEIDMKEALASGQFRALTRKEIELHCAMLGLDSELVSHSRIRGLSGGQKVKLVLAACTWQRPHLI 918

  Fly   529 LLDEPTNHLDMETIDALADAINDFDGGMVLVSHDFRLINQVAEEIWVCEKETVT----KWKGG-- 587
            :||||||:||.:::.||:.|:..|:||:::::|.......:.:|:|..:...:|    .|..|
Yeast   919 VLDEPTNYLDRDSLGALSKALKAFEGGVIIITHSAEFTKNLTDEVWAVKDGKMTPSGHNWVAGQG 983

  Fly   588 ---ILDYK-------DHLKNKITSENEKKAK 608
               .::.|       |.:.|||.| .:||:|
Yeast   984 AGPRIEKKEEEGDKFDAMGNKINS-GKKKSK 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9281	NP_001285284.1	Uup	71..597	CDD:223562	176/677 (26%)
		ABCF_EF-3	74..292	CDD:213188	75/238 (32%)
		ABC_tran_Xtn	286..373	CDD:289608	16/86 (19%)
		ABCF_EF-3	386..578	CDD:213188	78/300 (26%)
HEF3	NP_014384.3	HEAT repeat	129..158	CDD:293787
		HEAT repeat	170..200	CDD:293787
		HEAT repeat	208..232	CDD:293787
		HEAT repeat	244..273	CDD:293787
		4HB	336..411	CDD:407796	7/45 (16%)
		Uup	429..986	CDD:223562	173/652 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770