DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9281 and YEF3

DIOPT Version :9

Sequence 1:	NP_001285284.1	Gene:	CG9281 / 32508	FlyBaseID:	FBgn0030672	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_013350.1	Gene:	YEF3 / 850951	SGDID:	S000004239	Length:	1044	Species:	Saccharomyces cerevisiae

Alignment Length:	718	Identity:	185/718 - (25%)
Similarity:	267/718 - (37%)	Gaps:	255/718 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 EKLCAKLEEEARISAEARSCTGSLAVHP-------RSRDVKIANFSITFFGSELLQDTMLELNCG 99
            ||....:.:|.|     :....::.|.|       ...|:....||:.:....||..|.|.|...
Yeast   397 EKKAKDILDEFR-----KRAVDNIPVGPNFDDEEDEGEDLCNCEFSLAYGAKILLNKTQLRLKRA 456

  Fly   100 RRYGLIGLNGCGKSSLL-AVLGG-----------REVPVPPHIDIFHLTREIPASSKSALQCVME 152
            ||||:.|.||||||:|: |:..|           |.|.|...||..|       |..|.|..|.|
Yeast   457 RRYGICGPNGCGKSTLMRAIANGQVDGFPTQEECRTVYVEHDIDGTH-------SDTSVLDFVFE 514

  Fly   153 V---DEERIKLEKLAEELAMSEEDDAQEQLIDIYERLDDMSADLAEVKAARILHGLGFDKAMQQK 214
            .   .:|.|| :||.|                                       .||...|...
Yeast   515 SGVGTKEAIK-DKLIE---------------------------------------FGFTDEMIAM 539

  Fly   215 QAKDFSGGWRMRIALARALFVKPHLLLLDEPTNHLDLDACVWLEEELKTYKRILVLISHSQDFLN 279
            .....||||:|::|||||:.....:|||||||||||.....||...|.|.....:.|||...||:
Yeast   540 PISALSGGWKMKLALARAVLRNADILLLDEPTNHLDTVNVAWLVNYLNTCGITSITISHDSVFLD 604

  Fly   280 GVCTNIIHLTGKRLKYYTGNYEAFVRTRMELLENQMKQYNWEQDQISHMKNYIARFGHGSAKLAR 344
            .||..||:..|.:|:.|.||:..||:
Yeast   605 NVCEYIINYEGLKLRKYKGNFTEFVK--------------------------------------- 630

  Fly   345 QAQSKEKTLAKMVAQGLTEKVSDDKVLNFYFPSCGKV------PPPVIMVQNVNFRYNDETPWIY 403
                      |..|....|::|:.. |.|.||..|.:      ...::.|.|:.|:|...:....
Yeast   631 ----------KCPAAKAYEELSNTD-LEFKFPEPGYLEGVKTKQKAIVKVTNMEFQYPGTSKPQI 684

  Fly   404 KNLEFGIDLDTRLALVGPNGAGKSTLLKLLYGDLVPTSGMIRKNSHLRIARYHQH--LHELLDLD 466
            .::.|...|.:|:|::||||||||||:.:|.|:|:||||.:..:.:.|||...||  .|....||
Yeast   685 TDINFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHENCRIAYIKQHAFAHIESHLD 749

  Fly   467 ASPLEYMMRAFPDVKEKEEM-------------------------RKIIGRYG------------ 494
            .:|.||:...|...:::|.|                         |:|.|.:.
Yeast   750 KTPSEYIQWRFQTGEDRETMDRANRQINENDAEAMNKIFKIEGTPRRIAGIHSRRKFKNTYEYEC 814

  Fly   495 --LTG----------------------------------------------------RQQV---C 502
              |.|                                                    |:::   |
Yeast   815 SFLLGENIGMKSERWVPMMSVDNAWIPRGELVESHSKMVAEVDMKEALASGQFRPLTRKEIEEHC 879

  Fly   503 P-------------IRQLSDGQRCRVVFAWLAWQVPHLLLLDEPTNHLDMETIDALADAINDFDG 554
            .             ||.||.||:.::|.|...||.|||::||||||:||.:::.||:.|:.:|:|
Yeast   880 SMLGLDPEIVSHSRIRGLSGGQKVKLVLAAGTWQRPHLIVLDEPTNYLDRDSLGALSKALKEFEG 944

  Fly   555 GMVLVSHDFRLINQVAEEIWVCEKETVT----KWKGG------------ILDYKDHLKNKITSEN 603
            |:::::|.......:.||:|..:...:|    .|..|            ..|..|.:.|||....
Yeast   945 GVIIITHSAEFTKNLTEEVWAVKDGRMTPSGHNWVSGQGAGPRIEKKEDEEDKFDAMGNKIAGGK 1009

  Fly   604 EKK 606
            :||
Yeast  1010 KKK 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9281	NP_001285284.1	Uup	71..597	CDD:223562	174/671 (26%)
		ABCF_EF-3	74..292	CDD:213188	76/232 (33%)
		ABC_tran_Xtn	286..373	CDD:289608	13/86 (15%)
		ABCF_EF-3	386..578	CDD:213188	77/300 (26%)
YEF3	NP_013350.1	HEAT repeat	129..158	CDD:293787
		HEAT repeat	170..200	CDD:293787
		HEAT repeat	208..232	CDD:293787
		HEAT repeat	244..273	CDD:293787
		4HB	336..411	CDD:407796	4/18 (22%)
		Uup	431..986	CDD:223562	171/651 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770