DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9281 and ABCF1

DIOPT Version :9

Sequence 1:	NP_001285284.1	Gene:	CG9281 / 32508	FlyBaseID:	FBgn0030672	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001020262.1	Gene:	ABCF1 / 23	HGNCID:	70	Length:	845	Species:	Homo sapiens

Alignment Length:	636	Identity:	244/636 - (38%)
Similarity:	362/636 - (56%)	Gaps:	65/636 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KKREAQKKKDARNKKIQQIPSTKKANGVPERE---------------LTEEEKLCAKLEEEARI- 54
            |::|..|:...:.||.:| .|.::..|..|.|               ..|::||..::|.|.::
Human   209 KEKEPPKQGKEKAKKAEQ-GSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVA 272

  Fly    55 ------------SAEARSCTGSLAVHPRSRDVKIANFSITFFGSELLQDTMLELNCGRRYGLIGL 107
                        |......:...|:...:.|:|:..|||:..|.||..:..|.:..||||||:|.
Human   273 SLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGP 337

  Fly   108 NGCGKSSLLAVLGGREVPVPPHIDIFHLTREIPASSKSALQCVMEVDEERIKLEKLAEELAM--- 169
            ||.||::||..:..|.:.:||:||:....:|:.|....|:|.|:..|.:|:||  |.||..:
Human   338 NGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKL--LEEERRLQGQ 400

  Fly   170 --SEEDDAQEQLIDIYERLDDMSADLAEVKAARILHGLGFDKAMQQKQAKDFSGGWRMRIALARA 232
              ..:|.|.|:|..:||.|....|..||.||.|||.|||||..||.:..:.||||||||::||||
Human   401 LEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARA 465

  Fly   233 LFVKPHLLLLDEPTNHLDLDACVWLEEELKTYKRILVLISHSQDFLNGVCTNIIHLTGKRLKYYT 297
            ||::|.||:||||||||||:|.:||...|:.:::.|:::||.|.||:.|||:||||..:||.||.
Human   466 LFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYR 530

  Fly   298 GNYEAFVRTRMELLENQMKQYNWEQDQISHMKNYIARFGHGSAKLARQAQSKEKTLAKMVAQGLT 362
            |||..|.:...:..:..:|||..::.::..:|        ...|..:||:.:.|.......|...
Human   531 GNYMTFKKMYQQKQKELLKQYEKQEKKLKELK--------AGGKSTKQAEKQTKEALTRKQQKCR 587

  Fly   363 EKVSDDK--------------VLNFYFPSCGKVPPPVIMVQNVNFRYNDETPWIYKNLEFGIDLD 413
            .|..|::              .:.|.||....:.|||:.:..|.|.|..:.| ::|||:||||:|
Human   588 RKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKP-LFKNLDFGIDMD 651

  Fly   414 TRLALVGPNGAGKSTLLKLLYGDLVPTSGMIRKNSHLRIARYHQHLHELLDLDASPLEYMMRAF- 477
            :|:.:|||||.||||||.||.|.|.||.|.:|||..|:|..::|...|.|.::.:|.||:.|.|
Human   652 SRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFN 716

  Fly   478 -PDVKEKEEMRKIIGRYGLTGRQQVCPIRQLSDGQRCRVVFAWLAWQVPHLLLLDEPTNHLDMET 541
             |    .::.||.:||:||........|.:||.||:.|||||.||.:.|.:|:||||||:||:|:
Human   717 LP----YQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIES 777

  Fly   542 IDALADAINDFDGGMVLVSHDFRLINQVAEEIWVCEKETVTKWKGGILDYK 592
            ||||.:|||::.|.:::||||.|||.:...::||.|:::|::..|...|||
Human   778 IDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYK 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9281	NP_001285284.1	Uup	71..597	CDD:223562	227/543 (42%)
		ABCF_EF-3	74..292	CDD:213188	104/222 (47%)
		ABC_tran_Xtn	286..373	CDD:289608	22/100 (22%)
		ABCF_EF-3	386..578	CDD:213188	91/193 (47%)
ABCF1	NP_001020262.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..261		11/52 (21%)
		Uup	302..833	CDD:223562	227/542 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..602		8/50 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53504
OrthoDB	1	1.010	-	-		D249617at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830