DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sog and chrd.1

DIOPT Version :9

Sequence 1:	NP_001259576.1	Gene:	sog / 32498	FlyBaseID:	FBgn0003463	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	XP_012818430.1	Gene:	chrd.1 / 549011	XenbaseID:	XB-GENE-480638	Length:	942	Species:	Xenopus tropicalis

Alignment Length:	1007	Identity:	270/1007 - (26%)
Similarity:	437/1007 - (43%)	Gaps:	192/1007 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 RSNRPAVTECQFGKVLRELGSTWYADLGPPFGVMYCIKCECVAIPKKR-RIVARVQCRNIKNECP 156
            :|..||  .|.||.....|..:|:.|||.|||||:|:.|.|.....:| :...:|.|:|||::||
Frog    36 QSKTPA--GCTFGGKFYSLEDSWHPDLGDPFGVMHCVLCYCEPQRSRRGKPSGKVSCKNIKHDCP 98

  Fly   157 PAKCDDPISLPGKCCKTCP----------------------------GDRN--DTDVALDVPVPN 191
            ...|.:|:.|.|.||||||                            .||:  .:|   ||.|
Frog    99 SPSCSNPVLLSGHCCKTCPKAPPPPIKKSDFVFDGFEYFHGKDDDLYNDRSYLSSD---DVTV-- 158

  Fly   192 EEEERNMKHYAALLTGRTSYFLKGEEMKSMYTTYNPQNV-------VATARFLFHKKNLYYSFYT 249
               |.|...|.||||.                   |.:|       ||.|||...:.:|.:|. |
Frog   159 ---EENRSEYVALLTA-------------------PSHVWPPVTSGVAKARFNLQRSSLLFSI-T 200

  Fly   250 SSRIGRPRAIQFVDDAGVILEEHQLETTLAGTLSVYQNATGK---ICGVWRRVPRDYKRILRDDR 311
            ...|.|...|:|.|..|.:|.||          .|::..:.:   |||:||.:.|...|:||...
Frog   201 YKWIDRLSRIRFSDLEGSVLFEH----------PVHRMGSPRGDTICGIWRSLNRSTLRLLRMGH 255

  Fly   312 LHVVLLWGNKQQAELALAGKVAKYTALQTELFSSLLEAPLPDGKTDPQLAGAGGTAIVSTSSGAA 376
            :.|.|:.....:.|  ::||:.|:.||.:|.||:||   .|:   |..:.|.||.|:: |.|...
Frog   256 ILVSLVTTTLSEPE--ISGKIVKHKALFSESFSALL---TPE---DSDVTGGGGLAML-TLSDVD 311

  Fly   377 SSMHLTLVFNGVFGAEEYADAALSVKIELAERKEVIFDEIPRVRKPSAEINVLELSSPISIQNLR 441
            .::|..|:..|:.|.|.   ..:.:.:::..:..||.:....:  .:.|.:..|:...:|.:.::
Frog   312 DNLHFILMLRGLRGGER---DQIQILVQILHQNHVIRELYANI--SAQEQDFAEVLPDLSSREMQ 371

  Fly   442 LMSRGKLLLTVESKKYPHLRIQGHIVTRASCEIFQTLLAPHSAESSTKSS--GLAWVYLNTDGSL 504
            .:::|:|.::|:::.....|:.|.|..|.||:..|::|:...|.:.||:.  |.|.:.|:.:|::
Frog   372 WLAQGQLEISVQTEGRRGQRMSGIITVRKSCDTLQSVLSGGDALNPTKTGAVGSASITLHENGTM 436

  Fly   505 AYNIETEHVNTRDRPNISLIEEQGKRKAK---LEDLTPSFNFNQAIGSVEKLGPKVLESLYAGEL 566
            .|.|:.  ..|........:|.:.:||.|   |.|:|..:...:..|.......:.|..|...||
Frog   437 EYQIQI--AGTTSAVTAVTLETKPRRKTKRNILHDMTKDYQDGRVWGYWIDANARDLHMLLQSEL 499

  Fly   567 GVNVAT-EHETSLIRGRLVPRPVAD--ARDSAEPILLKRQEHTDAQNPHAVGMAWMSIDNECNLH 628
            .:|||| :.:...:||::.|...:.  ||....|:.|..|..:......:.|.||:|:|..|:||
Frog   500 FLNVATKDFQEGELRGQITPLLYSGLWARYEQLPVPLAGQFVSPPIRTGSAGHAWVSLDEHCHLH 564

  Fly   629 YEVTLNGV-PAQDLQLYLEEKPIEAIG-----APVTRKLLEEFNGSYLEGFFLSMPSAELIKLEM 687
            |::.:.|: .|:|..|.........:|     .|..::||:.|.||..:|....:....|..|..
Frog   565 YQIVVTGLGKAEDAALNAHLHGFAELGEVGESTPGHKRLLKGFYGSEAQGSVKDLDLELLGHLSR 629

  Fly   688 SVCYLEVHSKHSKQLLLRGKLKSTKVPGHC---------------FPVYTDNNVPVPGDHNDNHL 737
            ...:::|.:|.:.:..:||::   .:|.:|               :.:|.:.....|.|     |
Frog   630 GTAFIQVSTKLNPRGEIRGQV---HIPNNCESGGVSLTPEEPEYEYELYEEGRQRDPED-----L 686

  Fly   738 VNGETKCFHSGRFYNESEQWRSAQD-SCQMCACLRGQSSCEVIKCPALKCKSTEQLLQRDGECCP 801
            ......||..|:......:|....| .|.:|:|.:....|:.|.||.|.|   .|.:....:|||
Frog   687 RKDPRACFFEGQLRAHGSRWAPDYDRKCSVCSCQKRTVICDPIVCPPLNC---SQPVHLSDQCCP 748

  Fly   802 SCVPKKEAADYSAQSSPATNATDLLQQRRGCRL-GEQ-FHPAGASWHPFLPPNGFDTCTTCSCDP 864
            .|..|||..:.. ::..|..|.:      ||.. |:: :..||..||||:||.|...|..|:|..
Frog   749 VCEEKKEIREVK-KTERARTANE------GCFFDGDRSWKAAGTRWHPFVPPFGLIKCAICTCKG 806

  Fly   865 LTLEIRCPRLVCPPLQCSEKLAYRPDKKACCKICPEGKQSSSNGHKTTPNNPNVLQDQAMQRSPS 929
            .|.|:.|.::.||.|.|:..:...|..  |||.||                       ..:|||.
Frog   807 STGEVHCEKVTCPRLSCTNPIRANPSD--CCKQCP-----------------------VEERSPL 846

  Fly   930 HSAEEVLANG--GCKVVNKVYENGQEWHPILMSHGEQKCIKCRCKDSKVNCDRKRCSRSTCQQQT 992
            ..|:.:.::|  .||.....|.|.:.|||.:...||.||:.|.|.:....|.|:.|:.:||.
Frog   847 ELADSMQSDGPRSCKFGRHWYPNNERWHPTVTPFGEMKCVTCACVEGVTQCRRQECTGNTCG--- 908

  Fly   993 RVTSKRRLFEKPDAAAPAIDECCSTQCRRSRR 1024
              |..:|            |.|| |:|:.:::
Frog   909 --TGSKR------------DRCC-TKCKDAKQ 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sog	NP_001259576.1	VWC	102..174	CDD:278520	31/72 (43%)
		CHRD	200..334	CDD:214804	39/143 (27%)
		CHRD	341..467	CDD:214804	28/125 (22%)
		CHRD	473..585	CDD:214804	30/117 (26%)
		CHRD	594..708	CDD:214804	30/119 (25%)
		VWC	744..803	CDD:278520	18/59 (31%)
		VWC	832..898	CDD:278520	25/67 (37%)
		VWC	941..1017	CDD:278520	23/75 (31%)
chrd.1	XP_012818430.1	VWC	43..116	CDD:327433	31/72 (43%)
		CHRD	163..276	CDD:214804	39/144 (27%)
		CHRD	283..397	CDD:214804	28/125 (22%)
		CHRD	403..519	CDD:214804	30/117 (26%)
		CHRD	530..651	CDD:214804	30/123 (24%)
		VWC	693..750	CDD:278520	18/59 (31%)
		VWC	772..838	CDD:214564	25/67 (37%)
		VWC	860..920	CDD:327433	24/77 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	80	1.000	Domainoid score	I8525
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2774
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2453
OMA	1	1.010	-	-		QHG49605
OrthoDB	1	1.010	-	-		D289212at33208
OrthoFinder	1	1.000	-	-		FOG0008063
OrthoInspector	1	1.000	-	-		oto102621
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4763
SonicParanoid	1	1.000	-	-		X6013
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.010