Protein Alignment sog and CRIM1

DIOPT Version :10

• Sequence 1: NP_476736.1
• Gene: sog / 32498
• FlyBaseID: FBgn0003463
• Length: 1038
• Species: Drosophila melanogaster
• Sequence 2: XP_011531200.1
• Gene: CRIM1 / 51232
• HGNCID: 2359
• Length: 1077
• Species: Homo sapiens
• Alignment Length: 981
• Identity: 183/981 - (18%)
• Similarity: 308/981 - (31%)
• Gaps: 328/981 - (33%)

  Fly   155 CPPAKCDDPISLPGK-------CCKTCPGDRNDT-----------DVALDVPVPNEEEERNMKHY 201
            |..:||::|.:.||.       ||.||...||::           |..|...:.......::..|
Human    40 CDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRCVIRPPLNGDSLTEY 104

  Fly   202 AALLTGRTSYFLKGEEMKSMYTTYNPQNVVATARFLFHKKNLYYSFYTSSRIGRPRAIQFVDDAG 266
            .|   |....|...::   :|..:...:.....|..|.||.|......||         :::|
Human   105 EA---GVCEVFSLNDK---IYGKHGISDTPTAPRLPFLKKELEEPSDVSS---------YLED-- 152

  Fly   267 VILEEHQLETTLAGTLSVYQN-------ATGKI-CGVWRRVPRDY------------KRILRDDR 311
                |:..:..|.|.....:|       ..||. |...|.....:            |||
Human   153 ----ENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRI----- 208

  Fly   312 LHVVLLWGNKQQAELALAGKVAKYTALQTELFSSLLEAPLPDGKTDP--------------QLAG 362
                    .:::.:.:.|....:::....| .|.|:|...|.|:..|              ::..
Human   209 --------EEEKPDCSKARCEVQFSPRCPE-DSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQ 264

  Fly   363 AGG-TAIVSTSSGAASSMHLTLVFNGVFGAEEYADAALSVKIELAERKEVIFDEIPRVRKPSAEI 426
            .|. ..:||.:||.............|||.:     ..:|             |.|.|::.:...
Human   265 PGNLNILVSKASGKPGECCDLYECKPVFGVD-----CRTV-------------ECPPVQQTACPP 311

  Fly   427 NVLELSSPISIQNLRLMSRGKLLL--------------TVESKKYPHLRIQGHIVTRASCEIFQT 477
            :..|       ..:||.:.|...|              ..|....|.:..:|.......|::|:.
Human   312 DSYE-------TQVRLTADGCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFEC 369

  Fly   478 LLAPHSAESSTKSSGLAWVYLNT---DG-----------------SLAYNIETEHVNTRDRPNIS 522
            :       :.||.   |.|:.|.   ||                 ::.:..:...:|. :|..:
Human   370 V-------NDTKP---ACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINC-ERYYV- 422

  Fly   523 LIEEQGKRKAKLEDLTPSFNFNQAIGSVEKLGPKVLESLYAGEL-----------------GVNV 570
               .:|:.....||  |.:.||...|            .||..|                 .||
Human   423 ---PEGECCPVCED--PVYPFNNPAG------------CYANGLILAHGDRWREDDCTFCQCVN- 469

  Fly   571 ATEHETSLIRGRLVPRPVADARDSA----EPILLKRQEHTDAQNPHAVGMAWMSIDNECNLHYEV 631
            ...|..:.:.|:....||....:..    ||.::       ..:|.|.|    .:.| |.|..:.
Human   470 GERHCVATVCGQTCTNPVKVPGECCPVCEEPTII-------TVDPPACG----ELSN-CTLTGKD 522

  Fly   632 TLNGVPAQDLQLYLEEKPIEAIGAPVTRKLLEEFNGSYLEGFFLSMPSAELIKLE-MSVCYLEVH 695
            .:||....    :...:..:.|..       ||......:|..|:.|...|...: ..:|.....
Human   523 CINGFKRD----HNGCRTCQCINT-------EELCSERKQGCTLNCPFGFLTDAQNCEICECRPR 576

  Fly   696 SKHSKQLLL-----RGKLKSTKVPGHC----FPVYTDNNVPVPGDHNDNH--LVNGETKCFHS-- 747
            .|..:.::.     .|.||:......|    .|..:.:.:...|...|:|  |:   .||..:
Human   577 PKKCRPIICDKYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLI---CKCREASA 638

  Fly   748 ---------------GRFYNESEQWRSAQDSCQMCACLRGQSSCEVIKCPALKCKSTEQLLQRDG 797
                           |..:...|.|   .|.|:.|.||.|:..|.:|.||...|.:.   ....|
Human   639 SAGPPILSGTCLTVDGHHHKNEESW---HDGCRECYCLNGREMCALITCPVPACGNP---TIHPG 697

  Fly   798 ECCPSCVPKKEAADYSAQ----SSPATNATDLLQQRRGCRL-GEQFHPAGASWHPFLPPNGFDTC 857
            :|||||     |.|:..|    |:|:.           |.. |.::...|.:|:       .|:|
Human   698 QCCPSC-----ADDFVVQKPELSTPSI-----------CHAPGGEYFVEGETWN-------IDSC 739

  Fly   858 TTCSCDPLTLEIRCPRLVCPPLQCSEKLAYRPDK--KACCKICPEGKQSSSNGHKTTPNNPNVLQ 920
            |.|:|.  :..:.|...|||||.|.     .|.:  .:||..|.:           .|..|::.:
Human   740 TQCTCH--SGRVLCETEVCPPLLCQ-----NPSRTQDSCCPQCTD-----------QPFRPSLSR 786

  Fly   921 DQAMQRSPSHSAEEVLANGGCK-VVNKVYENGQEWHPILMSHGEQKCIKCRCKDSKVNCDRKRCS 984
            :.::   |::          || ....::...:.|.|       ..|..|.|.||.::|..:.|.
Human   787 NNSV---PNY----------CKNDEGDIFLAAESWKP-------DVCTSCICIDSVISCFSESCP 831

  Fly   985 RSTCQQ 990
            ..:|::
Human   832 SVSCER 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sog	NP_476736.1	VWC	102..174	CDD:278520	8/25 (32%)
		CHRD	200..334	CDD:214804	25/153 (16%)
		CHRD	341..467	CDD:214804	27/154 (18%)
		CHRD	473..585	CDD:214804	24/148 (16%)
		CHRD	594..708	CDD:214804	20/123 (16%)
		VWC	744..803	CDD:278520	19/75 (25%)
		VWC	832..898	CDD:278520	19/68 (28%)
		VWC	941..1017	CDD:278520	12/51 (24%)
CRIM1	XP_011531200.1	IGFBP	39..90	CDD:459717	14/49 (29%)
		VWC	377..431	CDD:214564	7/58 (12%)
		VWC	444..497	CDD:214564	9/53 (17%)
		Antistasin	608..633	CDD:460713	5/27 (19%)
		VWC	653..703	CDD:450195	18/55 (33%)
		VWC	724..775	CDD:450195	18/64 (28%)
		VWC	799..849	CDD:214564	10/46 (22%)
		VWC	860..914	CDD:450195
		CRIM1_C	948..1077	CDD:437274