Protein Alignment sog and VWC2

DIOPT Version :10

• Sequence 1: NP_476736.1
• Gene: sog / 32498
• FlyBaseID: FBgn0003463
• Length: 1038
• Species: Drosophila melanogaster
• Sequence 2: NP_940972.2
• Gene: VWC2 / 375567
• HGNCID: 30200
• Length: 325
• Species: Homo sapiens
• Alignment Length: 247
• Identity: 51/247 - (20%)
• Similarity: 81/247 - (32%)
• Gaps: 84/247 - (34%)

  Fly   747 SGRFYNESEQWRSAQDSCQMCACLRGQSSCEVIKCPAL--KCKSTEQLLQRDGECCPSCVPKKEA 809
            ||..|...|::.....:|. |.|......|...:||.|  :|...:     ..:|||.|..:|..
Human   159 SGFVYAIGEKFAPGPSACP-CLCTEEGPLCAQPECPRLHPRCIHVD-----TSQCCPQCKERKNY 217

  Fly   810 ADYSAQSSPATNATDLLQQRRGCRLGEQFHPAGASWHPFLPPNGFDTCTTCSCDPLTLEIRCPRL 874
            .::..::....               |:|         .:.|     |..|.|: ...|:.|...
Human   218 CEFRGKTYQTL---------------EEF---------VVSP-----CERCRCE-ANGEVLCTVS 252

  Fly   875 VCPPLQCSEKLAYRPDKKACCKICPEGKQSSSNGHKTTPNNPNVLQDQAMQRSPSHSAEEVLANG 939
            .||..:|.:.: |.||:  ||.||              .|.||...:.|:    ..:..||..:
Human   253 ACPQTECVDPV-YEPDQ--CCPIC--------------KNGPNCFAETAV----IPAGREVKTD- 295

  Fly   940 GCKVVNKVYENGQEWHPILMSHGEQKCIKCRCKDSKVNCDRK-RCSRSTCQQ 990
            .|.:.:..||.| .|                      ..:|: .|:|..|:|
Human   296 ECTICHCTYEEG-TW----------------------RIERQAMCTRHECRQ 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sog	NP_476736.1	VWC	102..174	CDD:278520
		CHRD	200..334	CDD:214804
		CHRD	341..467	CDD:214804
		CHRD	473..585	CDD:214804
		CHRD	594..708	CDD:214804
		VWC	744..803	CDD:278520	15/57 (26%)
		VWC	832..898	CDD:278520	16/65 (25%)
		VWC	941..1017	CDD:278520	10/51 (20%)
VWC2	NP_940972.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..121
		Mediates cell adhesion. /evidence=ECO:0000250	114..116
		VWC	218..273	CDD:450195	16/87 (18%)