DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sog and CHRDL2

DIOPT Version :9

Sequence 1:	NP_001259576.1	Gene:	sog / 32498	FlyBaseID:	FBgn0003463	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_056239.3	Gene:	CHRDL2 / 25884	HGNCID:	24168	Length:	451	Species:	Homo sapiens

Alignment Length:	321	Identity:	80/321 - (24%)
Similarity:	111/321 - (34%)	Gaps:	61/321 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   744 CFHSGRFYNESEQWRSAQDS-----CQMCACLRG-QSSCEVIKCPALKCKSTEQLLQRDGECCPS 802
            |...|:.|:..|.|....:.     |..|.|..| ..||..:.||.:.|   .|.:....:|||.
Human    33 CLFHGKRYSPGESWHPYLEPQGLMYCLRCTCSEGAHVSCYRLHCPPVHC---PQPVTEPQQCCPK 94

  Fly   803 CVPKKEAADYSAQSSPATNATDLLQQRRGCRLGEQFHPAGASWHPFLPPNGFDTCTTCSCDPLTL 867
            ||.....:...|......:...:.|.      ||.|     |.|...|....:.|..|||  ...
Human    95 CVEPHTPSGLRAPPKSCQHNGTMYQH------GEIF-----SAHELFPSRLPNQCVLCSC--TEG 146

  Fly   868 EIRCPRLVCPPLQCSEKLAYRPDKKACCKIC----------------------PEGKQSSSNGHK 910
            :|.|....||...|...|.. ||  :||:.|                      |:...||..|.|
Human   147 QIYCGLTTCPEPGCPAPLPL-PD--SCCQACKDEASEQSDEEDSVQSLHGVRHPQDPCSSDAGRK 208

  Fly   911 TTPNNPNVLQDQA-MQRSPSHSAEEVLANGGCKVV------------NKVYENGQEWHPILMSHG 962
            ..|..|......| :...|.|...:...:...|:|            .|.|.:|:.|||...:.|
Human   209 RGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTVKIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFG 273

  Fly   963 EQKCIKCRCKDSKVNCDRKRC-SRSTCQQQTRVTSKRRLFEKPDAAAPAIDECCSTQCRRS 1022
            ...||.|.|:|.:.:|.|..| :...|:...:|..|.......|.|.|...|..||:|.::
Human   274 PLPCILCTCEDGRQDCQRVTCPTEYPCRHPEKVAGKCCKICPEDKADPGHSEISSTRCPKA 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sog	NP_001259576.1	VWC	102..174	CDD:278520
		CHRD	200..334	CDD:214804
		CHRD	341..467	CDD:214804
		CHRD	473..585	CDD:214804
		CHRD	594..708	CDD:214804
		VWC	744..803	CDD:278520	18/64 (28%)
		VWC	832..898	CDD:278520	20/65 (31%)
		VWC	941..1017	CDD:278520	24/88 (27%)
CHRDL2	NP_056239.3	VWC	33..95	CDD:214564	18/64 (28%)
		VWC	111..174	CDD:302663	21/78 (27%)
		VWC	252..314	CDD:214564	18/61 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12115
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910