DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9220 and Chsy1

DIOPT Version :9

Sequence 1:	NP_001285280.1	Gene:	CG9220 / 32497	FlyBaseID:	FBgn0030662	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_001099738.1	Gene:	Chsy1 / 292999	RGDID:	1311904	Length:	788	Species:	Rattus norvegicus

Alignment Length:	834	Identity:	341/834 - (40%)
Similarity:	482/834 - (57%)	Gaps:	116/834 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LGLCIGTMLKNYLAL---EIVKRCSLR----PTNLK----------TPADIIGL----------- 57
            |||.:|.:|.:.|.|   ..:||...|    |...:          .|.|..|.
  Rat     3 LGLVLGFVLASRLVLPRASELKRVGPRRRPNPEGCRPGQAASQPGGAPGDARGAQLWPQGSAAEG 67

  Fly    58 --RDEDTIQNSQRNLVFVGVMTAKSFLEGRARAVYDTWGKEVPGRMAFFSSEGS-YSDDLPVVGL 119
              ||        ||.:|||||||:.:|:.||.|.|.||.|.:||::.||||||| .|..:|||.|
  Rat    68 VPRD--------RNFLFVGVMTAQKYLQTRAVAAYRTWSKTIPGKVEFFSSEGSDTSIPIPVVPL 124

  Fly   120 KNVDDRYPPQKKSFMMLYYMYEHYIDRFEWFIRADDDVYMEPDKLERFLRSIDSSKPQFIGQAGK 184
            :.|||.|||||||||||.||::||:|::|||:|||||||::.|:||.||||::||:|.|:||.|.
  Rat   125 RGVDDSYPPQKKSFMMLKYMHDHYLDKYEWFMRADDDVYIKGDRLESFLRSLNSSEPLFLGQTGL 189

  Fly   185 GNSEEFGLLSLEFDENFCMGGPGVILSSETLRRVAPHIPSCLKNLYSTHEDVEVGRCVQKFAGIP 249
            |.:||.|.|:||..|||||||||||||.|.|||:||||..||:.:|:|||||||||||::|||:.
  Rat   190 GTTEEMGKLALEPGENFCMGGPGVILSREVLRRMAPHIGKCLREMYTTHEDVEVGRCVRRFAGVQ 254

  Fly   250 CTWNYEMQYILRHN-SSGRNAYTGKLKRKEIHNAITLHPIKQAPLMYRLHSYVQGLKAEEMRQES 313
            |.|:||||.:...| ...:..|...|...:||.||||||.|..|..||||||:...|..|:|..:
  Rat   255 CVWSYEMQQLFYENYEQNKKGYIRDLHSSKIHRAITLHPNKNPPYQYRLHSYMLSRKIAELRHRT 319

  Fly   314 LLLHRDIKRMAKYLEVPDESTYMLPSVSPESDSTKRHFQDHNILGISPELNKFVPASTDDLLDWS 378
            :.|||:|..|:||                  .||:...:|.. |||.|...:|.....:::|:|.
  Rat   320 IQLHREIVLMSKY------------------SSTEIQKEDLQ-LGIPPSFMRFQARQREEILEWE 365

  Fly   379 FI-ARSLYSASSANPKQK-IDSAMREGLEDAITEVMENINNYSRQRGRVIEFRELLYGYHRLDAL 441
            |: .:.||||:...|.:: :|||.||.|:|.:.:|||.||..::.|||:|:|:|:.|||.|::.:
  Rat   366 FLTGKYLYSATEGQPPRRGMDSAQREALDDIVLQVMEMINANAKTRGRIIDFKEIQYGYRRVNPM 430

  Fly   442 HGQDMILDLLLIYKKYRGKKMTVPVRRHLYVQRAFTGI-FVKEVDEDFYNVT---LQQSLLGSLF 502
            :|.:.||||||:|||::|||||||||||.|:|:.|:.| ||:....|...:.   .|.|...|..
  Rat   431 YGAEYILDLLLLYKKHKGKKMTVPVRRHAYLQQTFSKIQFVEHEGLDAQELADRINQDSGSLSFL 495

  Fly   503 QNGMARLSSHFTMPSGLL---SPTQDKIVFVLPIAGRLGTFERFLRTYERVCVRGEQHCDLLVVI 564
            .|.:.:|.. |.:|...:   .|.:.||..::|::||...|.||:..:|:.|:....:..|::::
  Rat   496 SNSLKKLVP-FQLPGSKMEHKEPKEKKINILIPLSGRFDMFVRFMGNFEKTCLIPNLNVKLVILL 559

  Fly   565 FGS---PDELGDHLQLLHDLHARHVYQQVNWIQRSSAFSRGVALDVAARSSYIRQEDIILFIDVD 626
            |.|   ||: ...::|:.|...::....:..:..|..|||.:||:|.  ||....|.::.|.|||
  Rat   560 FNSDSNPDK-AKQVELMRDYRVKYPKADMQVLPVSGGFSRALALEVG--SSQFSNESLLFFCDVD 621

  Fly   627 MVFEVETLQRVRMHTQRGKQVYLPIVFSQYDPQRRSGDAGGSEDEGETP-----RIDDERGYFRQ 686
            :||..|.|||.|.:|..|:|:|.||:||||||:        ....|:.|     ....:.|::|.
  Rat   622 LVFTAEFLQRCRANTVLGQQIYFPIIFSQYDPK--------IVYSGKVPSDNHFAFTQKTGFWRN 678

  Fly   687 FGFGICAIYKSDILDEDINGFDKDITGWGLEDVKFLEKIVRVGTRQRGFLANTAELAMDYNEAAE 751
            :||||..|||.|::  .:.|||..|.|||||||....|:|:.|
  Rat   679 YGFGITCIYKGDLV--RVGGFDVSIQGWGLEDVDLFNKVVQAG---------------------- 719

  Fly   752 QWRRLSVFRAPDPTLVHIYHDISCDVQLDAPQYNMCLGTKANSLGSTRLMEQLF 805
                |..||:.:..:||::|.:.||..||..||.||||:||::.|||:.:.:::
  Rat   720 ----LKTFRSQEVGVVHVHHPVFCDPNLDPKQYKMCLGSKASTFGSTQQLAEMW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9220	NP_001285280.1	Galactosyl_T	71..>251	CDD:304462	117/180 (65%)
CG9220	NP_001285280.1	CHGN	221..799	CDD:283361	224/595 (38%)
Chsy1	NP_001099738.1	Galactosyl_T	75..296	CDD:304462	134/220 (61%)
Chsy1	NP_001099738.1	CHGN	226..765	CDD:283361	225/597 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341515
Domainoid	1	1.000	391	1.000	Domainoid score	I751
eggNOG	1	0.900	-	-		E1_KOG3588
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8950
Inparanoid	1	1.050	597	1.000	Inparanoid score	I922
OMA	1	1.010	-	-		QHG49419
OrthoDB	1	1.010	-	-		D211685at33208
OrthoFinder	1	1.000	-	-		FOG0002300
OrthoInspector	1	1.000	-	-		otm45485
orthoMCL	1	0.900	-	-		OOG6_104399
Panther	1	1.100	-	-	LDO	PTHR12369
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2344
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770