DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9220 and CHSY1

DIOPT Version :9

Sequence 1:	NP_001285280.1	Gene:	CG9220 / 32497	FlyBaseID:	FBgn0030662	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	XP_011519666.1	Gene:	CHSY1 / 22856	HGNCID:	17198	Length:	830	Species:	Homo sapiens

Alignment Length:	862	Identity:	338/862 - (39%)
Similarity:	484/862 - (56%)	Gaps:	133/862 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FFGIALGLCIGTMLKNYLALEIVKRCSLRPTNLKTPADIIGLRDEDTIQNS-------------- 66
            :..:.|||.:|.:|.:.|.|.  :...|:....:..|...|.|......:.
Human     9 WLSVLLGLVLGFVLASRLVLP--RASELKRAGPRRRASPEGCRSGQAAASQAGGARGDARGAQLW 71

  Fly    67 -----------QRNLVFVGVMTAKSFLEGRARAVYDTWGKEVPGRMAFFSSEGS-YSDDLPVVGL 119
                       .||.:|||||||:.:|:.||.|.|.||.|.:||::.||||||| .|..:|||.|
Human    72 PPGSDPDGGPRDRNFLFVGVMTAQKYLQTRAVAAYRTWSKTIPGKVQFFSSEGSDTSVPIPVVPL 136

  Fly   120 KNVDDRYPPQKKSFMMLYYMYEHYIDRFEWFIRADDDVYMEPDKLERFLRSIDSSKPQFIGQAGK 184
            :.|||.|||||||||||.||::||:|::|||:|||||||::.|:||.||||::||:|.|:||.|.
Human   137 RGVDDSYPPQKKSFMMLKYMHDHYLDKYEWFMRADDDVYIKGDRLENFLRSLNSSEPLFLGQTGL 201

  Fly   185 GNSEEFGLLSLEFDENFCMGGPGVILSSETLRRVAPHIPSCLKNLYSTHEDVEVGRCVQKFAGIP 249
            |.:||.|.|:||..|||||||||||:|.|.|||:.|||..||:.:|:|||||||||||::|||:.
Human   202 GTTEEMGKLALEPGENFCMGGPGVIMSREVLRRMVPHIGKCLREMYTTHEDVEVGRCVRRFAGVQ 266

  Fly   250 CTWNYEMQYI------LRHN-----------------------SSGRNAYTGKLKRKEIHNAITL 285
            |.|:||...:      |||:                       ...:..|...|...:||.||||
Human   267 CVWSYEASPVACLCQCLRHSLFLMILTVLRSASQMQQLFYENYEQNKKGYIRDLHNSKIHQAITL 331

  Fly   286 HPIKQAPLMYRLHSYVQGLKAEEMRQESLLLHRDIKRMAKYLEVPDESTYMLPSVSPESDSTKRH 350
            ||.|..|..||||||:...|..|:|..::.|||:|..|:||                  .:|:.|
Human   332 HPNKNPPYQYRLHSYMLSRKISELRHRTIQLHREIVLMSKY------------------SNTEIH 378

  Fly   351 FQDHNILGISPELNKFVPASTDDLLDWSFI-ARSLYSASSANPKQK-IDSAMREGLEDAITEVME 413
            .:|.. |||.|...:|.|...:::|:|.|: .:.||||....|.:: :|||.||.|:|.:.:|||
Human   379 KEDLQ-LGIPPSFMRFQPRQREEILEWEFLTGKYLYSAVDGQPPRRGMDSAQREALDDIVMQVME 442

  Fly   414 NINNYSRQRGRVIEFRELLYGYHRLDALHGQDMILDLLLIYKKYRGKKMTVPVRRHLYVQRAFTG 478
            .||..::.|||:|:|:|:.|||.|::.::|.:.||||||:|||::|||||||||||.|:|:.|:.
Human   443 MINANAKTRGRIIDFKEIQYGYRRVNPMYGAEYILDLLLLYKKHKGKKMTVPVRRHAYLQQTFSK 507

  Fly   479 I-FVKEVDEDFYNVTL---QQSLLGSLFQNGMARLSSHFTMP---SGLLSPTQDKIVFVLPIAGR 536
            | ||:..:.|...:..   |:|...|...|.:.:|.. |.:|   |....|...||..::|::||
Human   508 IQFVEHEELDAQELAKRINQESGSLSFLSNSLKKLVP-FQLPGSKSEHKEPKDKKINILIPLSGR 571

  Fly   537 LGTFERFLRTYERVCVRGEQHCDLLVVIFGS---PDELGDHLQLLHDLHARHVYQQVNWIQRSSA 598
            ...|.||:..:|:.|:...|:..|:|::|.|   ||: ...::|:.|...::....:..:..|..
Human   572 FDMFVRFMGNFEKTCLIPNQNVKLVVLLFNSDSNPDK-AKQVELMRDYRIKYPKADMQILPVSGE 635

  Fly   599 FSRGVALDVAARSSYIRQEDIILFIDVDMVFEVETLQRVRMHTQRGKQVYLPIVFSQYDPQRRSG 663
            |||.:||:|.  ||....|.::.|.|||:||..|.|||.|.:|..|:|:|.||:||||||:
Human   636 FSRALALEVG--SSQFNNESLLFFCDVDLVFTTEFLQRCRANTVLGQQIYFPIIFSQYDPK---- 694

  Fly   664 DAGGSEDEGETP-----RIDDERGYFRQFGFGICAIYKSDILDEDINGFDKDITGWGLEDVKFLE 723
                ....|:.|     ....:.|::|.:||||..|||.|::  .:.|||..|.|||||||....
Human   695 ----IVYSGKVPSDNHFAFTQKTGFWRNYGFGITCIYKGDLV--RVGGFDVSIQGWGLEDVDLFN 753

  Fly   724 KIVRVGTRQRGFLANTAELAMDYNEAAEQWRRLSVFRAPDPTLVHIYHDISCDVQLDAPQYNMCL 788
            |:|:.|                          |..||:.:..:||::|.:.||..||..||.|||
Human   754 KVVQAG--------------------------LKTFRSQEVGVVHVHHPVFCDPNLDPKQYKMCL 792

  Fly   789 GTKANSLGSTRLMEQLF 805
            |:||::.|||:.:.:::
Human   793 GSKASTYGSTQQLAEMW 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9220	NP_001285280.1	Galactosyl_T	71..>251	CDD:304462	115/180 (64%)
CG9220	NP_001285280.1	CHGN	221..799	CDD:283361	228/623 (37%)
CHSY1	XP_011519666.1	Galactosyl_T	87..>265	CDD:304462	114/177 (64%)
CHSY1	XP_011519666.1	CHGN	238..805	CDD:283361	229/625 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147687
Domainoid	1	1.000	397	1.000	Domainoid score	I748
eggNOG	1	0.900	-	-		E1_KOG3588
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8950
Inparanoid	1	1.050	602	1.000	Inparanoid score	I953
Isobase	1	0.950	-	0.938488	Normalized mean entropy	S4160
OMA	1	1.010	-	-		QHG49419
OrthoDB	1	1.010	-	-		D211685at33208
OrthoFinder	1	1.000	-	-		FOG0002300
OrthoInspector	1	1.000	-	-		otm41360
orthoMCL	1	0.900	-	-		OOG6_104399
Panther	1	1.100	-	-	LDO	PTHR12369
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3461
SonicParanoid	1	1.000	-	-		X2344
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750