DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9220 and chsy1

DIOPT Version :9

Sequence 1:	NP_001285280.1	Gene:	CG9220 / 32497	FlyBaseID:	FBgn0030662	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_001090724.1	Gene:	chsy1 / 100036707	XenbaseID:	XB-GENE-961883	Length:	812	Species:	Xenopus tropicalis

Alignment Length:	783	Identity:	325/783 - (41%)
Similarity:	472/783 - (60%)	Gaps:	91/783 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LKTPADIIGLRDEDTIQNSQRNLVFVGVMTAKSFLEGRARAVYDTWGKEVPGRMAFFSSEGS-YS 111
            |.|....:....|:.|. :.:|.:|||||||:.:||.||.|.|.||...:||::.||||||| .|
Frog    75 LHTDTGALSPASEEDIP-TDKNFLFVGVMTAQKYLETRAVAAYGTWANSIPGKVEFFSSEGSDTS 138

  Fly   112 DDLPVVGLKNVDDRYPPQKKSFMMLYYMYEHYIDRFEWFIRADDDVYMEPDKLERFLRSIDSSKP 176
            ..:|:|.|:.|||.|||||||||||.||::||:|::|||:|||||||::.|:||.||||::||:|
Frog   139 IPIPIVPLQGVDDSYPPQKKSFMMLKYMHDHYLDQYEWFMRADDDVYIKGDRLENFLRSLNSSEP 203

  Fly   177 QFIGQAGKGNSEEFGLLSLEFDENFCMGGPGVILSSETLRRVAPHIPSCLKNLYSTHEDVEVGRC 241
            .|:||.|.|.:||.|.|:||..|||||||||||:|.|.||||.|||..||:.:::||||||:|||
Frog   204 LFLGQTGLGTTEEMGKLALEPGENFCMGGPGVIMSREVLRRVVPHIGECLRQMFTTHEDVEIGRC 268

  Fly   242 VQKFAGIPCTWNYEMQYILRHN-SSGRNAYTGKLKRKEIHNAITLHPIKQAPLMYRLHSYVQGLK 305
            |::|||:.|.|:||||.:...| ...:..|...|...:||.||||||.|..|..||||||:...|
Frog   269 VRRFAGVQCVWSYEMQQLFYENYEQNKKGYIRDLHNSKIHRAITLHPNKNPPYQYRLHSYMLSRK 333

  Fly   306 AEEMRQESLLLHRDIKRMAKYLEVPDESTYMLPSVSPESDSTKRHFQDHNILGISPELNKFVPAS 370
            ..|:|..::.|||:|..|:||                   |.....:|...|||:|...:|.|..
Frog   334 IAELRYRTIQLHREIVLMSKY-------------------SNAEIHKDDMQLGIAPSFMRFQPRQ 379

  Fly   371 TDDLLDWSFI-ARSLYSASSANPKQK-IDSAMREGLEDAITEVMENINNYSRQRGRVIEFRELLY 433
            .:::|:|.|: .:.|||.:...|.:: :||:.:|.|:|.:.:|||.||..::.|||:|:|:|:.|
Frog   380 REEILEWEFLTGKYLYSTADGQPPRRGMDSSQKEALDDIVMQVMEMINANAKVRGRIIDFKEIQY 444

  Fly   434 GYHRLDALHGQDMILDLLLIYKKYRGKKMTVPVRRHLYVQRAFTGI-FV--KEVD-EDFYNVTLQ 494
            ||.|::.::|.:.:|||||:|||::|||||||||||.|:|:.|:.| |:  :|:| :...|...|
Frog   445 GYRRVNPMYGAEYVLDLLLLYKKHKGKKMTVPVRRHAYLQQTFSKIQFMEHEEIDAKALANKINQ 509

  Fly   495 QSLLGSLFQNGMARLSSHFTM--PSGLLS-------PTQDKIVFVLPIAGRLGTFERFLRTYERV 550
            :|  ||.:     .||:...|  |..|.:       |.:.|:..::|::||...|.||:..:|:.
Frog   510 ES--GSFY-----FLSNSLKMFVPFHLTASKTEHKEPKETKVNILVPLSGRFDMFARFMANFEKT 567

  Fly   551 CVRGEQHCDLLVVIFGS---PDELGDHLQLLHDLHARHVYQQVNWIQRSSAFSRGVALDVAARSS 612
            |:...|:..|::::|.|   ||:. ..::|:.|...::....:..:..|..|||.:||:|.  ||
Frog   568 CLIPNQNVKLVILLFNSDSNPDKT-RQVELMRDYRVKYPKADMQILPVSGEFSRALALEVG--SS 629

  Fly   613 YIRQEDIILFIDVDMVFEVETLQRVRMHTQRGKQVYLPIVFSQYDPQRRSGDAGGSEDEGETP-- 675
            ..|.:.::.|.|||:||..|.:||.|.:|..|:|:|.||:||||||:        ....|:.|
Frog   630 QFRNDSLLFFCDVDLVFSTEFIQRCRANTILGQQIYFPIIFSQYDPK--------IVYAGKVPSD 686

  Fly   676 ---RIDDERGYFRQFGFGICAIYKSDILDEDINGFDKDITGWGLEDVKFLEKIVRVGTRQRGFLA 737
               ....:.|::|.:||||..:||.|:|  ...|||..|.|||||||....|:|:||
Frog   687 NHYAFTQKTGFWRNYGFGITCVYKGDLL--RAGGFDVSIQGWGLEDVDLFNKVVQVG-------- 741

  Fly   738 NTAELAMDYNEAAEQWRRLSVFRAPDPTLVHIYHDISCDVQLDAPQYNMCLGTKANSLGSTRLME 802
                              |..||:.:..:|||:|.:.||..||..||.||||:||::.|||:.:.
Frog   742 ------------------LKTFRSQEVGVVHIHHPVFCDPNLDPKQYKMCLGSKASTYGSTQRLA 788

  Fly   803 QLF 805
            :|:
Frog   789 ELW 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9220	NP_001285280.1	Galactosyl_T	71..>251	CDD:304462	113/180 (63%)
CG9220	NP_001285280.1	CHGN	221..799	CDD:283361	222/601 (37%)
chsy1	NP_001090724.1	Galactosyl_T	92..318	CDD:419759	131/225 (58%)
chsy1	NP_001090724.1	CHGN	248..787	CDD:399001	223/603 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	388	1.000	Domainoid score	I794
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8950
Inparanoid	1	1.050	592	1.000	Inparanoid score	I963
OMA	1	1.010	-	-		QHG49419
OrthoDB	1	1.010	-	-		D211685at33208
OrthoFinder	1	1.000	-	-		FOG0002300
OrthoInspector	1	1.000	-	-		otm48565
Panther	1	1.100	-	-	LDO	PTHR12369
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3461
SonicParanoid	1	1.000	-	-		X2344
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110