DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp11 and Alp1

DIOPT Version :9

Sequence 1:	NP_573047.1	Gene:	Alp11 / 32496	FlyBaseID:	FBgn0030661	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001262159.1	Gene:	Alp1 / 40372	FlyBaseID:	FBgn0283479	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	201/498 - (40%)
Similarity:	285/498 - (57%)	Gaps:	71/498 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ELLSSH-WLRQAQSQLRERLARTKDSIADVRQAKNVVMLLGDGLSITTLTAARILKGQRRGGRGE 99
            ||.|.. |...||..|..:|:...:..    :||||:..||||:|:.|:||.||..||.||..||
  Fly    36 ELKSKEFWFHDAQRTLYNKLSTPPNQY----RAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGE 96

  Fly   100 DAQLAVEQFPFSGLSKTYCIDEQTPDSACTATAYFGGVKTHSGTVGQSGSGE------------R 152
            ..:|..|:|.:.|||||||:::|..||||||:||..|:|.:..|:|.:...|            |
  Fly    97 RNRLEFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQNR 161

  Fly   153 VDSVLQWAQRAGKATGVVTTTRLTDASPAGAYAHVSRR---------------GEELEIARQLVE 202
            :.|:..||.:..|:.|:|||||:|.|||||.|||.|.|               |...:||:||::
  Fly   162 LSSIAAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQNPGNCPDIAQQLID 226

  Fly   203 EEPGRNLNVILGGGLGKF-----------ADERRDGKDLLAQWRESNPNGC---FSRSLKELRNC 253
            .:.|:.|.|::|||..||           ..:|.|.::|:.:|:::.|...   |||: ..|.|.
  Fly   227 GDVGKRLRVVMGGGTIKFLPNTTNDVFGNKGQRLDNRNLIEEWQQTKPGNARVVFSRT-DLLNND 290

  Fly   254 TDATGTLLGIFSDSHMSYHLAASKELPRLCDMAAAAIEKLERKSQEDGNGYFVFIEGGRIDHGHH 318
            ...|..|||:|:.||::||:..|.:.|.|.:|.||||..|.|    |.||||:|:|||||||.||
  Fly   291 AQNTDFLLGLFNASHLAYHMDDSIDTPTLPEMTAAAINVLSR----DPNGYFLFVEGGRIDHAHH 351

  Fly   319 ETRVGYALDEMVEFDAAVETVIQMTDPRDTLVVVTADHSHTLSMSGYAKRGTPILGMDAQQRDVN 383
            ||:...||||.|:|..||....|:|:|.|||:||:|||.||:::|||......|:|::::..:|:
  Fly   352 ETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPDVNNSIVGLNSELSNVD 416

  Fly   384 GVPYSTLNYAIGK-----WQSLD-----KDGRRESPSKTLSPTSYTPSYIHGRKGVHSGEDVVVF 438
            .:||::::||.|.     ::|.|     .|.|....||   |.:..|..:...:..|.|.||.|:
  Fly   417 QLPYTSISYANGPAYERFYKSTDGVVERVDLRNLDFSK---PDAIYPHGVPMTEETHGGGDVAVY 478

  Fly   439 A-------MGPQSHLFGGVMEQNLLPHIMGYAACLGNGLTLCN 474
            |       .||.||||.||.||:.|||:||:|:|||.|:|.|:
  Fly   479 AHVVEYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYCD 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp11	NP_573047.1	ALP_like	68..467	CDD:304875	187/456 (41%)
Alp1	NP_001262159.1	alkPPc	65..514	CDD:214515	187/456 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466648
Domainoid	1	1.000	141	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	10	9.900