DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp11 and Alp9

DIOPT Version :9

Sequence 1:	NP_573047.1	Gene:	Alp11 / 32496	FlyBaseID:	FBgn0030661	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001286944.1	Gene:	Alp9 / 38633	FlyBaseID:	FBgn0035620	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	203/507 - (40%)
Similarity:	281/507 - (55%)	Gaps:	67/507 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LHALIPILALSVPMVEQVQPADELLSSHWLRQAQSQLRERLARTKDSIADVRQAKNVVMLLGDGL 78
            :|..:|    :.|.:..:  :.|.....|...::..:||:|    :.:.:.::|||:::.||||:
  Fly    32 MHPHLP----TSPRLRTI--SGEETQEFWHSASKKLIREKL----EFVRNTKKAKNIILFLGDGM 86

  Fly    79 SITTLTAARILKGQRRGGRGEDAQLAVEQFPFSGLSKTYCIDEQTPDSACTATAYFGGVKTHSGT 143
            .:.||.|||...|      ||:.:|:.|:|||:||||||.:|:..||||||:|:|..|||.:.||
  Fly    87 GLATLAAARSYIG------GEELKLSFEEFPFTGLSKTYSVDKIVPDSACTSTSYLCGVKANYGT 145

  Fly   144 VGQSGSGERVD------------SVLQWAQRAGKATGVVTTTRLTDASPAGAYAHVSRRGEE--- 193
            :|.:...:|.|            |:.:||..||||.|:|||||:|.|||:|.||||:.|..|
  Fly   146 IGVNAHVKRGDCAAMANETNHVFSLGKWAMDAGKAAGLVTTTRVTHASPSGVYAHVADREWENNA 210

  Fly   194 -------------LEIARQLVEEEPGRNLNVILGGGLGKF-------ADERRDGKDLLAQWRESN 238
                         .:||.||:..|.|..|.|:||||...|       ...|.||::|:.::...:
  Fly   211 VLEEACGELSDGLQDIAVQLIHGEVGSKLKVMLGGGKRSFYSPEHYDKGRRTDGRNLVEEFEALD 275

  Fly   239 PNGCFSRSLKELRNC-TDATGTLLGIFSDSHMSYHLA----ASKELPRLCDMAAAAIEKLERKSQ 298
            ....|.::.|:|.|. ...||.|||:||.|||.|||.    .....|.|.:|...|||.||.:.|
  Fly   276 AGNTFVKTQKKLLNVNATETGRLLGLFSKSHMHYHLEQLADPDNNEPTLEEMTQKAIEVLETEEQ 340

  Fly   299 EDGNGYFVFIEGGRIDHGHHETRVGYALDEMVEFDAAVETVIQMTDPRDTLVVVTADHSHTLSMS 363
                |||:|:|||:||..||||....||||..|...||:...:||:|.:||:|||:|||||.|:|
  Fly   341 ----GYFLFVEGGKIDISHHETMARIALDETAELSKAVKKAREMTNPEETLIVVTSDHSHTFSVS 401

  Fly   364 GYAKRGTPILGMDAQQRDVNGVPYSTLNYAIGK-WQSLDKDGRRESPSKTLSPT-----SYTPSY 422
            ||..||:.|.|. |:....:|.||..|:||.|| :|........|....|..||     ...|:.
  Fly   402 GYQPRGSDIFGA-AKANGKDGKPYLALSYANGKSFQDYYNTETHERVDPTSLPTIGDFDQLFPAM 465

  Fly   423 IHGRKGVHSGEDVVVFAMGPQSHLFGGVMEQNLLPHIMGYAACLGNGLTLCN 474
            :......|.||||.|||.||.:|||.||.|||.:||:|.:|||:|:|||.|:
  Fly   466 VPLESETHGGEDVGVFASGPWAHLFTGVYEQNTIPHMMAFAACVGDGLTACD 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp11	NP_573047.1	ALP_like	68..467	CDD:304875	189/444 (43%)
Alp9	NP_001286944.1	PRK10518	12..496	CDD:236706	189/484 (39%)
Alp9	NP_001286944.1	ALP_like	75..508	CDD:304875	188/443 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466650
Domainoid	1	1.000	141	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	10	9.900