Protein Alignment Alp11 and ALPP

DIOPT Version :9

• Sequence 1: NP_573047.1
• Gene: Alp11 / 32496
• FlyBaseID: FBgn0030661
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_001623.3
• Gene: ALPP / 250
• HGNCID: 439
• Length: 535
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 198/513 - (38%)
• Similarity: 274/513 - (53%)
• Gaps: 67/513 - (13%)

  Fly     8 LAILFLLHALIPILALSVPMVEQVQPADELLSSHWLRQAQSQLRERLARTKDSIADVRQAKNVVM 72
            :.:|.||..|...|:|.:..||:..|      ..|.|:|    .|.|...|........|||:::
Human     6 MLLLLLLLGLRLQLSLGIIPVEEENP------DFWNREA----AEALGAAKKLQPAQTAAKNLII 60

  Fly    73 LLGDGLSITTLTAARILKGQRRGGRGEDAQLAVEQFPFSGLSKTYCIDEQTPDSACTATAYFGGV 137
            .||||:.::|:|||||||||::...|.:..||:::||:..|||||.:|:..|||..|||||..||
Human    61 FLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGV 125

  Fly   138 KTHSGTVGQSGS----------GERVDSVLQWAQRAGKATGVVTTTRLTDASPAGAYAHVSRRG- 191
            |.:..|:|.|.:          |..|.||:..|::|||:.|||||||:..|||||.|||...|.
Human   126 KGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNW 190

  Fly   192 -----------EE--LEIARQLVEEEPGRNLNVILGGG------LG----KFADE------RRDG 227
                       :|  .:||.||:.   ..:::||||||      :|    ::.|:      |.||
Human   191 YSDADVPASARQEGCQDIATQLIS---NMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDG 252

  Fly   228 KDLLAQWRESNPNGCFSRSLKELRNCT-DATGT-LLGIFSDSHMSYHLAASKEL-PRLCDMAAAA 289
            |:|:.:|........:..:..||...: |.:.| |:|:|....|.|.:.....| |.|.:|..||
Human   253 KNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAA 317

  Fly   290 IEKLERKSQEDGNGYFVFIEGGRIDHGHHETRVGYALDEMVEFDAAVETVIQMTDPRDTLVVVTA 354
            :..|.|..:    |:|:|:|||||||||||:|...||.|.:.||.|:|...|:|...|||.:|||
Human   318 LRLLSRNPR----GFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTA 378

  Fly   355 DHSHTLSMSGYAKRGTPILGM-DAQQRDVNGVPYSTLNYAIGKWQSLDKDGRRE--SPSKTLSPT 416
            ||||..|..||..||:.|.|: ..:.||...  |:.|.|..|....| |||.|.  :.|::.||.
Human   379 DHSHVFSFGGYPLRGSSIFGLAPGKARDRKA--YTVLLYGNGPGYVL-KDGARPDVTESESGSPE 440

  Fly   417 SYTPSYIHGRKGVHSGEDVVVFAMGPQSHLFGGVMEQNLLPHIMGYAACLGNGLTLCN 474
            ....|.:...:..|:||||.|||.|||:||..||.||..:.|:|.:|||| ...|.|:
Human   441 YRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACL-EPYTACD 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp11	NP_573047.1	ALP_like	68..467	CDD:304875	179/444 (40%)
ALPP	NP_001623.3	PRK10518	28..478	CDD:236706	181/469 (39%)
		Alk_phosphatase	55..490	CDD:278666	179/444 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..449		7/23 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157490
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760