Protein Alignment Alp11 and ALPL

DIOPT Version :10

• Sequence 1: NP_573047.1
• Gene: Alp11 / 32496
• FlyBaseID: FBgn0030661
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_000469.3
• Gene: ALPL / 249
• HGNCID: 438
• Length: 524
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 197/523 - (37%)
• Similarity: 264/523 - (50%)
• Gaps: 81/523 - (15%)

  Fly    20 ILALSVPMVEQVQPADELLSSHWLRQAQSQLRERLARTKDSIADVRQAKNVVMLLGDGLSITTLT 84
            :||:...:...:.|..|....:|..|||..|:..|...|   .:...||||:|.||||:.::|:|
Human     7 VLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQK---LNTNVAKNVIMFLGDGMGVSTVT 68

  Fly    85 AARILKGQRRGGRGEDAQLAVEQFPFSGLSKTYCIDEQTPDSACTATAYFGGVKTHSGTVGQSGS 149
            ||||||||.....||:.:|.:::|||..|||||..:.|.||||.|||||..|||.:.||||.|.:
Human    69 AARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAA 133

  Fly   150 GER----------VDSVLQWAQRAGKATGVVTTTRLTDASPAGAYAHVSRRG---------EEL- 194
            .||          |.|:|:||:.|||:.|:|||||:..|:|:.||||.:.|.         |.|
Human   134 TERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALS 198

  Fly   195 ----EIARQLVEEEPGRNLNVILGGGLGKF------------ADE-----RRDGKDLLAQWRESN 238
                :||.||:...  |:::||:||| .|:            :||     |.||.||:..|:...
Human   199 QGCKDIAYQLMHNI--RDIDVIMGGG-RKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFK 260

  Fly   239 PNGCFSRSLKELRNCTDA-------TGTLLGIFSDSHMSYHLAASKEL-PRLCDMAAAAIEKLER 295
            |....|..   :.|.|:.       ...|||:|....|.|.|..:... |.|.:|...||:.|.:
Human   261 PRYKHSHF---IWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRK 322

  Fly   296 KSQEDGNGYFVFIEGGRIDHGHHETRVGYALDEMVEFDAAVETVIQMTDPRDTLVVVTADHSHTL 360
            ..:    |:|:.:|||||||||||.:...||.|.||.|.|:.....:|...|||.||||||||..
Human   323 NPK----GFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVF 383

  Fly   361 SMSGYAKRGTPILGMDAQQRDVNGVPYSTLNYAIGKWQSLDKDGRRESPSKTLSPTSYTPSYIHG 425
            :..||..||..|.|:.....|.:..|::.:.|..|....: ..|.||:.|..        .|.|.
Human   384 TFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKV-VGGERENVSMV--------DYAHN 439

  Fly   426 ----------RKGVHSGEDVVVFAMGPQSHLFGGVMEQNLLPHIMGYAACLGNGLTLCNQDKDAD 480
                      |...|.||||.||:.||.:||..||.|||.:||:|.||||:|..|..|.....|.
Human   440 NYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAG 504

  Fly   481 MIA 483
            .:|
Human   505 SLA 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp11	NP_573047.1	ALP_like	68..467	CDD:474031	180/457 (39%)
ALPL	NP_000469.3	Alk_phosphatase	51..490	CDD:395188	180/457 (39%)