DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp11 and Alpi

DIOPT Version :9

Sequence 1:	NP_573047.1	Gene:	Alp11 / 32496	FlyBaseID:	FBgn0030661	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_073156.3	Gene:	Alpi / 24197	RGDID:	2099	Length:	540	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	189/522 - (36%)
Similarity:	268/522 - (51%)	Gaps:	77/522 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILFLLHALIPILALSVPMVEQVQPADELLSSHWLRQAQSQL--RERLARTKDSIADVRQAKNVVM 72
            :|.||..|...|:..|..||:..|.      .|.::|:..|  .::|...:.|      |||:::
  Rat     6 VLLLLLGLRIHLSFGVIPVEEENPV------FWNQKAKEALDVAKKLQPIQTS------AKNLIL 58

  Fly    73 LLGDGLSITTLTAARILKGQRRGGRGEDAQLAVEQFPFSGLSKTYCIDEQTPDSACTATAYFGGV 137
            .||||:.:.|:||.||||||..|..|.:..||::.|||:.|||||.:|.|.||||.|||||..||
  Rat    59 FLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGV 123

  Fly   138 KTHSGTVGQSGS----------GERVDSVLQWAQRAGKATGVVTTTRLTDASPAGAYAHVSRRG- 191
            |.:..|:|.|.:          |..|.||:..|::|||:.|||||||:..|||||.|||...|.
  Rat   124 KANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDW 188

  Fly   192 -----------EE--LEIARQLVEEEPGRNLNVILGGGLGKF--------------ADE---RRD 226
                       :|  .:||.||:.   ..:::|||||| .||              :|:   |.|
  Rat   189 YSDADMPSSALQEGCKDIATQLIS---NMDIDVILGGG-RKFMFPKGTPDPEYPGDSDQSGVRLD 249

  Fly   227 GKDLLAQWRESNPNGCFSRSLKELRNCTD--ATGTLLGIFSDSHMSYHL--AASKELPRLCDMAA 287
            .::|:.:|........:..:.::|...:.  |...|:|:|..:.|.|.:  .||.: |.|.:|..
  Rat   250 SRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPAEMKYDVNRNASAD-PSLAEMTE 313

  Fly   288 AAIEKLERKSQEDGNGYFVFIEGGRIDHGHHETRVGYALDEMVEFDAAVETVIQMTDPRDTLVVV 352
            .|:..|.|..|    |:::|:||||||.|||......||.|.|.||:|:|...|:|:.:|||.::
  Rat   314 VAVRLLSRNPQ----GFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLI 374

  Fly   353 TADHSHTLSMSGYAKRGTPILG---MDAQQRDVNGVPYSTLNYAIGKWQSLDKDGRRESPSKTLS 414
            ||||||..:..||..|||.|.|   ::||    :|..|:::.|..|....|:...|.........
  Rat   375 TADHSHVFAFGGYTLRGTSIFGLAPLNAQ----DGKSYTSILYGNGPGYVLNSGNRPNVTDAESG 435

  Fly   415 PTSY-TPSYIHGRKGVHSGEDVVVFAMGPQSHLFGGVMEQNLLPHIMGYAACLGNGLTLCNQDKD 478
            ..:| ..:.:......|.||||.:||.|||:||..||.|||.:.|:|.:|.|| ...|.|.....
  Rat   436 DVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCL-EPYTDCGLAPP 499

  Fly   479 AD 480
            ||
  Rat   500 AD 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp11	NP_573047.1	ALP_like	68..467	CDD:304875	169/447 (38%)
Alpi	NP_073156.3	Alk_phosphatase	53..488	CDD:278666	169/447 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.760