DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp11 and Akp3

DIOPT Version :9

Sequence 1:	NP_573047.1	Gene:	Alp11 / 32496	FlyBaseID:	FBgn0030661	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_031458.2	Gene:	Akp3 / 11648	MGIID:	87984	Length:	559	Species:	Mus musculus

Alignment Length:	521	Identity:	196/521 - (37%)
Similarity:	275/521 - (52%)	Gaps:	78/521 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LFLLHALIPILALSVPMVEQVQPADELLSSHWLRQAQSQL--RERLARTKDSIADVRQAKNVVML 73
            :.||..|...|:|||..||:..||      .|.::|...|  .::|...:.|      |||:::.
Mouse     6 VLLLLGLRLQLSLSVIPVEEENPA------FWNKKAAEALDAAKKLQPIQTS------AKNLIIF 58

  Fly    74 LGDGLSITTLTAARILKGQRRGGRGEDAQLAVEQFPFSGLSKTYCIDEQTPDSACTATAYFGGVK 138
            ||||:.:.|:||.||||||..|..|.:..||:::||:..|||||.:|.|.||||.|||||..|||
Mouse    59 LGDGMGVPTVTATRILKGQLEGHLGPETPLAMDRFPYMALSKTYSVDRQVPDSASTATAYLCGVK 123

  Fly   139 THSGTVGQSGS----------GERVDSVLQWAQRAGKATGVVTTTRLTDASPAGAYAHVSRR--- 190
            |:..|:|.|.:          |..|.||:..|::|||:.|||||||:..|||:|.|.|...|
Mouse   124 TNYKTIGVSAAARFDQCNTTFGNEVFSVMYRAKKAGKSVGVVTTTRVQHASPSGTYVHTVNRNWY 188

  Fly   191 GEE-----------LEIARQLVEEEPGRNLNVILGGGLGKF--------------ADE---RRDG 227
            |:.           .:||.||:.   ..::||||||| .|:              |:|   |.||
Mouse   189 GDADMPASALREGCKDIATQLIS---NMDINVILGGG-RKYMFPAGTPDPEYPNDANETGTRLDG 249

  Fly   228 KDLLAQWRESNPNGCFSRSLKEL-RNCTDATGT-LLGIFSDSHMSYHLAASKEL-PRLCDMAAAA 289
            ::|:.:|...:....:..:.::| :...|.:.| |:|:|......:.:.....: |.|.||..||
Mouse   250 RNLVQEWLSKHQGSQYVWNREQLIQKAQDPSVTYLMGLFEPVDTKFDIQRDPLMDPSLKDMTEAA 314

  Fly   290 IEKLERKSQEDGNGYFVFIEGGRIDHGHHETRVGYALDEMVEFDAAVETVIQMTDPRDTLVVVTA 354
            ::.|.|..:    |:::|:||||||.|||......||.|.|.||.|:|...|:|..||||.:|||
Mouse   315 VKVLSRNPK----GFYLFVEGGRIDRGHHLGTAYLALTEAVMFDLAIERASQLTSERDTLTIVTA 375

  Fly   355 DHSHTLSMSGYAKRGTPILGMDAQQRDVNGVPYSTLNYAIGKWQSLDKDGRRESPSKTLSPTSYT 419
            ||||..|..||..|||.|.|: |....::|.||:::.|..|....    |..|.|:.|.:.:|.:
Mouse   376 DHSHVFSFGGYTLRGTSIFGL-APLNALDGKPYTSILYGNGPGYV----GTGERPNVTAAESSGS 435

  Fly   420 PSY-----IHGRKGVHSGEDVVVFAMGPQSHLFGGVMEQNLLPHIMGYAACLGNGLTLCNQDKDA 479
             ||     :..:...|.||||.:||.|||:||..||.|||.:.|:|.:|.|| ...|.|.....|
Mouse   436 -SYRQQAAVPVKSETHGGEDVAIFARGPQAHLLHGVQEQNYIAHVMAFAGCL-EPYTDCGLAPPA 498

  Fly   480 D 480
            |
Mouse   499 D 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp11	NP_573047.1	ALP_like	68..467	CDD:304875	174/447 (39%)
Akp3	NP_031458.2	Alk_phosphatase	52..486	CDD:278666	174/447 (39%)
Akp3	NP_031458.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..531		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847870
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.760