DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp11 and Alpl

DIOPT Version :9

Sequence 1:	NP_573047.1	Gene:	Alp11 / 32496	FlyBaseID:	FBgn0030661	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001274101.1	Gene:	Alpl / 11647	MGIID:	87983	Length:	524	Species:	Mus musculus

Alignment Length:	512	Identity:	194/512 - (37%)
Similarity:	260/512 - (50%)	Gaps:	79/512 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ILALSVPMVEQVQPADELLSSHWLRQAQSQLRERLARTKDSIADVRQAKNVVMLLGDGLSITTLT 84
            :||:...:.....|..|...|:|.:|||..|:..|...|   .:...||||:|.||||:.::|:|
Mouse     7 VLAIGTCLTNSFVPEKERDPSYWRQQAQETLKNALKLQK---LNTNVAKNVIMFLGDGMGVSTVT 68

  Fly    85 AARILKGQRRGGRGEDAQLAVEQFPFSGLSKTYCIDEQTPDSACTATAYFGGVKTHSGTVGQSGS 149
            ||||||||.....||:.:|.:::|||..|||||..:.|.||||.|||||..|||.:.||||.|.:
Mouse    69 AARILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAA 133

  Fly   150 GER----------VDSVLQWAQRAGKATGVVTTTRLTDASPAGAYAHVSRRG---------EEL- 194
            .||          |.|:|:||:.|||:.|:|||||:..|:|:.||||.:.|.         |.|
Mouse   134 TERTRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALS 198

  Fly   195 ----EIARQLVEEEPGRNLNVILGGGL----------------GKFADERRDGKDLLAQWRESNP 239
                :||.||:...  ::::||:|||.                .|....|.||.||::.|:...|
Mouse   199 QGCKDIAYQLMHNI--KDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKP 261

  Fly   240 NGCFSRSLKELRNCTDATGT-------LLGIFSDSHMSYHLAASKEL-PRLCDMAAAAIEKLERK 296
            ....|.   .:.|.|:....       |||:|....|.|.|..:... |.|.:|...|:..|.:.
Mouse   262 RHKHSH---YVWNRTELLALDPSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRILTKN 323

  Fly   297 SQEDGNGYFVFIEGGRIDHGHHETRVGYALDEMVEFDAAVETVIQMTDPRDTLVVVTADHSHTLS 361
            .:    |:|:.:|||||||||||.:...||.|.||.|.|:.....||..:|||.||||||||..:
Mouse   324 LK----GFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGKAGAMTSQKDTLTVVTADHSHVFT 384

  Fly   362 MSGYAKRGTPILGMDAQQRDVNGVPYSTLNYAIGKWQSLDKDGRRESPSKTLSPTSYTPSYIHG- 425
            ..||..||..|.|:.....|.:..|::.:.|..|....: .||.||:.|..        .|.|.
Mouse   385 FGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKV-VDGERENVSMV--------DYAHNN 440

  Fly   426 ---------RKGVHSGEDVVVFAMGPQSHLFGGVMEQNLLPHIMGYAACLGNGLTLC 473
                     |...|.||||.|||.||.:||..||.|||.:||:|.||:|:|..|..|
Mouse   441 YQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHC 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp11	NP_573047.1	ALP_like	68..467	CDD:304875	178/456 (39%)
Alpl	NP_001274101.1	Alk_phosphatase	51..490	CDD:333956	178/456 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847883
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.760