DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp11 and alp3

DIOPT Version :9

Sequence 1:	NP_573047.1	Gene:	Alp11 / 32496	FlyBaseID:	FBgn0030661	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001265768.1	Gene:	alp3 / 100330410	ZFINID:	ZDB-GENE-120919-1	Length:	534	Species:	Danio rerio

Alignment Length:	531	Identity:	186/531 - (35%)
Similarity:	266/531 - (50%)	Gaps:	105/531 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ILALSVPMVEQVQPADELLSSHWLRQAQSQLRERLARTKDSIADVRQAKNVVMLLGDGLSITTLT 84
            :|.::...||:..|      ..|.:.||:.||..|:|.    .:...|||:|:.||||:.:||:|
Zfish    12 LLTITSGSVEEENP------EFWRKSAQNTLRSALSRK----INTNVAKNIVLFLGDGMGVTTIT 66

  Fly    85 AARILKGQRRGGRGEDAQLAVEQFPFSGLSKTYCIDEQTPDSACTATAYFGGVKTHSGTVG---- 145
            ||||||||.:...||:..:.::.||..||:|.|.:|.|.||||.|||||..||||:..|||
Zfish    67 AARILKGQLQKHSGEETVMNMDTFPNVGLAKVYSVDFQIPDSAATATAYLCGVKTNLNTVGVSAA 131

  Fly   146 ------QSGSGERVDSVLQWAQRAGKATGVVTTTRLTDASPAGAYAHVSRR------------GE 192
                  :|..|..|.|:|:||:.|||:.|:|||||:..|:||.::||.:.|            ..
Zfish   132 ARNGVCRSQKGNEVTSILRWAKDAGKSVGIVTTTRVQHATPAASFAHSASRTWYSDADLPASAAT 196

  Fly   193 E--LEIARQLVEEEPGRNLNVILGGGL-----GKFAD-----------ERRDGKDLLAQWRESNP 239
            |  ::||.||:.   ..:::||:|||.     ..|.|           :||||::|:..|.:...
Zfish   197 EGCVDIATQLLH---NIDIDVIIGGGRKYMTPKGFPDPEYPSDASAQGQRRDGRNLIQDWIQMKE 258

  Fly   240 NGCFSRSLKELRNCTD-------ATGTLLGIFSDSHMSYHLAASKEL-PRLCDMAAAAIEKLERK 296
                .:..:.:.|.||       .|..|:.:|..:.:.:.:.....: |.:.:....||:.|::.
Zfish   259 ----GKVARYVWNKTDFDAVDPEKTDYLMALFEPADLRFDVERDHSMDPSISETTDKAIQILKKN 319

  Fly   297 SQEDGNGYFVFIEGGRIDHGHHETRVGYALDEMVEFDAAVETVIQMTDPRDTLVVVTADHSHTLS 361
            .:    |:|:.:||||||.|||.:|...||.|.|..|.||...:::||..:||.:|||||||..:
Zfish   320 PK----GFFLLVEGGRIDQGHHSSRASAALHEAVALDEAVSRGLELTDEEETLTIVTADHSHAFT 380

  Fly   362 MSGYAKRGTPILGMDAQQRDVNGVPYSTLNYAIG--------------KWQSLDKDGRRESPSKT 412
            .:||..||..|||....... :.:||:||.|..|              |..:.|||..::|....
Zfish   381 FNGYPFRGNSILGKSPIFAS-DFLPYTTLMYGNGPGHKITNNKRPDIRKVDTADKDYIQQSAVPL 444

  Fly   413 LSPTSYTPSYIHGRKGVHSGEDVVVFAMGPQSHLFGGVMEQNLLPHIMGYAACLGNGLTLC---- 473
            .|.|             |.||||.|||.||.:|||.||.|||.:||.|.||||:|.....|
Zfish   445 DSET-------------HGGEDVAVFARGPMAHLFQGVYEQNYIPHAMAYAACIGENQQHCAITA 496

  Fly   474 ----NQDKDAD 480
                |.|...|
Zfish   497 KPDENPDTSTD 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp11	NP_573047.1	ALP_like	68..467	CDD:304875	169/460 (37%)
alp3	NP_001265768.1	PhoA	30..482	CDD:224699	172/480 (36%)
alp3	NP_001265768.1	Alk_phosphatase	49..485	CDD:278666	169/460 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.860