DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8097 and DALRD3

DIOPT Version :9

Sequence 1:	NP_001285279.1	Gene:	CG8097 / 32495	FlyBaseID:	FBgn0030660	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_005265326.1	Gene:	DALRD3 / 55152	HGNCID:	25536	Length:	575	Species:	Homo sapiens

Alignment Length:	461	Identity:	105/461 - (22%)
Similarity:	179/461 - (38%)	Gaps:	118/461 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LKSQGLKLRIDGDELLPSPVD--RLELMEHSR-KWRFPLAEITVLNKERYSLRFQRHPIIAHVLN 130
            |::.|:.:|     |:|:..|  .|..::..| .|  |.|          |.|...|.:.:|.|.
Human   150 LRAHGVCVR-----LVPAVRDPHMLTFLQQLRVDW--PAA----------SERASSHTLRSHALE 197

  Fly   131 SVLTLRGDYGRSANNNQSRTICL----QLQAVVGAVDGGQDLRHYRLQQLYKILLRLVDYSSWRL 191
            . ||...| ||:.:......:||    :.|......|...| .....:.|..:|..|.: :.|..
Human   198 E-LTSAND-GRTLSPGILGRLCLKELVEEQGRTAGYDPNLD-NCLVTEDLLSVLAELQE-ALWHW 258

  Fly   192 VEPNDRQ------KDT---ICVTVELEKC---------------CNGKQPVEHVCLTCGPVLEPI 232
              |.|..      .||   .|:.|.:..|               ...|.|:....|.|||| :..
Human   259 --PEDSHPGLAGASDTGTGGCLVVHVVSCEEEFQQQKLDLLWQKLVDKAPLRQKHLICGPV-KVA 320

  Fly   233 NKGASSLTVDEYLKLR-CQHMELMATQRSG-MCPVP-------MSSLDTLTKRLAAAAVIVDLFV 288
            ....:.:|..||.:.| .|..:..|.:..| :...|       :.|:.|:...:.:.|....||:
Human   321 GAPGTLMTAPEYYEFRHTQVCKASALKHGGDLAQDPAWTEIFGVLSVATIKFEMLSTAPQSQLFL 385

  Fly   289 VRHSSAVSVVRNGVGICKGASYILYNSARLEALLRKFNYEVNNCAYEKLPLLDEIDLSVLEDDVD 353
            ....|::|.  .|.   |..::::||.|||..|...:...:....|...|.:..:|.|:|.|:.:
Human   386 ALADSSIST--KGT---KSGTFVMYNCARLATLFESYKCSMEQGLYPTFPPVSSLDFSLLHDEGE 445

  Fly   354 WELIYGYLLTFPELME--SIMDQLDQGHC---GLHLLVH------YVENLAAAFSRFYYHKKVL- 406
            |.|::..:|.||:|:.  :::|      |   |||:.|.      ::..|:..||.:|....:|
Human   446 WLLLFNSILPFPDLLSRTAVLD------CTAPGLHIAVRTEMICKFLVQLSMDFSSYYNRVHILG 504

  Fly   407 -------------------------------LQKRDELMPILYARIYLIKAVRQVLNTALAVLGI 440
                                           .:.|..|...::.|:.|::|||:||:|.||:||:
Human   505 VSTQQNGVGRAERYRVKAKEAEDETSRPFLFQEPRPHLFGQMFVRLQLLRAVREVLHTGLAMLGL 569

  Fly   441 EPVDYV 446
            .|:.::
Human   570 PPLSHI 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8097	NP_001285279.1	DALR_1	311..445	CDD:214846	44/176 (25%)
DALRD3	XP_005265326.1	DALR_1	403..575	CDD:214846	44/177 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146281
Domainoid	1	1.000	81	1.000	Domainoid score	I8555
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8236
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1367114at2759
OrthoFinder	1	1.000	-	-		FOG0008240
OrthoInspector	1	1.000	-	-		oto91848
orthoMCL	1	0.900	-	-		OOG6_107731
Panther	1	1.100	-	-	LDO	PTHR16043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5723
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.690