DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9215 and ZNF835

DIOPT Version :9

Sequence 1:	NP_573045.1	Gene:	CG9215 / 32494	FlyBaseID:	FBgn0030659	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001005850.2	Gene:	ZNF835 / 90485	HGNCID:	34332	Length:	537	Species:	Homo sapiens

Alignment Length:	346	Identity:	95/346 - (27%)
Similarity:	139/346 - (40%)	Gaps:	67/346 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 NVEPCSSSSVSGTITTSTEPSEDVKEEKTDSLSLIP-----DGAMVLSLNDFQAQDSITQQA--- 202
            |.|.|....   .:....:|:.|..:|: |..|.||     ..|...|:.|    ||.:::.
Human    30 NQESCPEPE---AVACKGDPAGDSMQER-DEFSRIPRTISSPAATQASVPD----DSSSRRCSAP 86

  Fly   203 ----EEKDPKKQQDEDEGQAKMLELDPWDDENTPEHLYEIETPLIEESV-VASPPLPLPPTHPAN 262
                :|:.|..:|.|..|..|    .||...:..:........::.:.: ....|...|....|.
Human    87 GESPKERHPDSRQRERGGGPK----KPWKCGDCGKAFSYCSAFILHQRIHTGEKPFACPECGKAF 147

  Fly   263 QQK------KRTYRRVSPNVKHEKLTANVDDDFKAGS---------------------------- 293
            .|.      :||:....|...||...|     |..||
Human   148 SQSVHLTLHQRTHTGEKPYACHECGKA-----FSQGSYLASHWRTHTGEKPHRCADCGKAFTRVT 207

  Fly   294 --TTKRR-NCERSPKICDVCGNTYKYQHALNAHMRRHNNERPYSCEVCQKAFISNVELRRHMRVH 355
              |..|| :....|..|..|...::.:.:|..|.|.|..|:||.|..|.|||..:..|.||.|:|
Human   208 HLTQHRRVHTGERPYACAQCAKAFRNRSSLIEHQRIHTGEKPYECSACAKAFRFSSALIRHQRIH 272

  Fly   356 TGQKPYSCRHCERRFSDFGSSKKHERIHTGERPYVCEVCNKGFAYAHVLSAHRRTHTGKKQFQCT 420
            |.:|||.|..|.:.|:......:|.|:||||:||.|:.|...|:.:..|:.|||.|||:|.:.|.
Human   273 TEEKPYRCGQCAKAFAQIAHLTQHRRVHTGEKPYTCQDCGALFSQSASLAEHRRIHTGEKPYACG 337

  Fly   421 QCDKGFTKKTYLSAHMEQHRG 441
            ||.|.||:.::|:.|...|.|
Human   338 QCAKAFTQVSHLTQHQRTHTG 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9215	NP_573045.1	zf-AD	16..92	CDD:285071
		DUF2117	165..>273	CDD:303038	26/126 (21%)
		COG5048	<303..439	CDD:227381	54/135 (40%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		zf-H2C2_2	319..344	CDD:290200	12/24 (50%)
		zf-C2H2	333..355	CDD:278523	10/21 (48%)
		C2H2 Zn finger	335..355	CDD:275368	9/19 (47%)
		zf-H2C2_2	347..371	CDD:290200	11/23 (48%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		zf-H2C2_2	375..400	CDD:290200	11/24 (46%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	404..427	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
ZNF835	NP_001005850.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..109		21/90 (23%)
		C2H2 Zn finger	112..132	CDD:275368	0/19 (0%)
		zf-H2C2_2	128..149	CDD:290200	3/20 (15%)
		COG5048	136..487	CDD:227381	72/228 (32%)
		C2H2 Zn finger	140..160	CDD:275368	4/19 (21%)
		zf-H2C2_2	152..177	CDD:290200	7/29 (24%)
		C2H2 Zn finger	168..188	CDD:275368	6/24 (25%)
		Ribosomal_L34e	178..>243	CDD:294621	10/64 (16%)
		C2H2 Zn finger	196..216	CDD:275368	3/19 (16%)
		C2H2 Zn finger	224..244	CDD:275368	5/19 (26%)
		zf-H2C2_2	236..259	CDD:290200	10/22 (45%)
		C2H2 Zn finger	252..272	CDD:275368	9/19 (47%)
		zf-H2C2_2	264..289	CDD:290200	12/24 (50%)
		C2H2 Zn finger	280..300	CDD:275368	5/19 (26%)
		zf-H2C2_2	292..317	CDD:290200	11/24 (46%)
		C2H2 Zn finger	308..328	CDD:275368	7/19 (37%)
		zf-H2C2_2	320..345	CDD:290200	13/24 (54%)
		C2H2 Zn finger	336..356	CDD:275368	8/19 (42%)
		zf-H2C2_2	348..373	CDD:290200	4/11 (36%)
		C2H2 Zn finger	364..384	CDD:275368
		zf-H2C2_2	376..401	CDD:290200
		C2H2 Zn finger	392..412	CDD:275368
		zf-H2C2_2	404..429	CDD:290200
		C2H2 Zn finger	420..440	CDD:275368
		zf-H2C2_2	432..457	CDD:290200
		C2H2 Zn finger	448..468	CDD:275368
		zf-C2H2	474..496	CDD:278523
		C2H2 Zn finger	476..496	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24404
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010