DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9215 and ZNF382

DIOPT Version :9

Sequence 1:	NP_573045.1	Gene:	CG9215 / 32494	FlyBaseID:	FBgn0030659	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_116214.2	Gene:	ZNF382 / 84911	HGNCID:	17409	Length:	550	Species:	Homo sapiens

Alignment Length:	230	Identity:	76/230 - (33%)
Similarity:	108/230 - (46%)	Gaps:	22/230 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 ENTPEHL------YEIETPLIEESVVASPPLPLPPTHPANQQKKRTYRRVSPNVKHEK------- 280
            |..|.|.      :..::.|||...:.:...|    :..||..| .:|:.:....|||
Human   292 EEKPFHCPYCGNNFRRKSYLIEHQRIHTGEKP----YVCNQCGK-AFRQKTALTLHEKTHIEGKP 351

  Fly   281 -LTANVDDDFKAGST-TKRRNCERSPKI--CDVCGNTYKYQHALNAHMRRHNNERPYSCEVCQKA 341
             :..:....|:..:| |:........|.  |..||:.::.:..|..|.|.|..|:||.|..|.||
Human   352 FICIDCGKSFRQKATLTRHHKTHTGEKAYECPQCGSAFRKKSYLIDHQRTHTGEKPYQCNECGKA 416

  Fly   342 FISNVELRRHMRVHTGQKPYSCRHCERRFSDFGSSKKHERIHTGERPYVCEVCNKGFAYAHVLSA 406
            ||....|..|.|.|||:|||.|..|.:.|....:...|:||||||:||:|..|.|.|....:|:.
Human   417 FIQKTTLTVHQRTHTGEKPYICNECGKSFCQKTTLTLHQRIHTGEKPYICNECGKSFRQKAILTV 481

  Fly   407 HRRTHTGKKQFQCTQCDKGFTKKTYLSAHMEQHRG 441
            |.|.|||:|...|.||.|.|::|:.|..|.:.|.|
Human   482 HHRIHTGEKSNGCPQCGKAFSRKSNLIRHQKTHTG 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9215	NP_573045.1	zf-AD	16..92	CDD:285071
		DUF2117	165..>273	CDD:303038	11/49 (22%)
		COG5048	<303..439	CDD:227381	57/137 (42%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		zf-H2C2_2	319..344	CDD:290200	12/24 (50%)
		zf-C2H2	333..355	CDD:278523	10/21 (48%)
		C2H2 Zn finger	335..355	CDD:275368	9/19 (47%)
		zf-H2C2_2	347..371	CDD:290200	11/23 (48%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		zf-H2C2_2	375..400	CDD:290200	13/24 (54%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	404..427	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
ZNF382	NP_116214.2	Mediates interaction with TRIM28. /evidence=ECO:0000250	1..105
		Represses transcription. /evidence=ECO:0000250	5..46
		KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		Represses transcription. /evidence=ECO:0000250	70..211
		C2H2 Zn finger	214..234	CDD:275368
		Required for transcriptional repression activity, probably mediates sequence-specific DNA-binding. /evidence=ECO:0000250	296..550		74/226 (33%)
		C2H2 Zn finger	298..318	CDD:275368	3/19 (16%)
		zf-H2C2_2	310..335	CDD:290200	7/29 (24%)
		C2H2 Zn finger	326..346	CDD:275368	7/20 (35%)
		COG5048	<354..533	CDD:227381	62/163 (38%)
		C2H2 Zn finger	354..374	CDD:275368	3/19 (16%)
		zf-H2C2_2	367..389	CDD:290200	5/21 (24%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..419	CDD:290200	12/24 (50%)
		C2H2 Zn finger	410..430	CDD:275368	9/19 (47%)
		zf-H2C2_2	423..445	CDD:290200	11/21 (52%)
		C2H2 Zn finger	438..458	CDD:275368	5/19 (26%)
		zf-H2C2_2	451..475	CDD:290200	13/23 (57%)
		C2H2 Zn finger	466..486	CDD:275368	7/19 (37%)
		C2H2 Zn finger	494..514	CDD:275368	8/19 (42%)
		zf-C2H2	494..514	CDD:278523	8/19 (42%)
		zf-H2C2_2	506..531	CDD:290200	4/11 (36%)
		C2H2 Zn finger	522..542	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24404
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100