DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9215 and ZNF613

DIOPT Version :9

Sequence 1:	NP_573045.1	Gene:	CG9215 / 32494	FlyBaseID:	FBgn0030659	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001026891.2	Gene:	ZNF613 / 79898	HGNCID:	25827	Length:	617	Species:	Homo sapiens

Alignment Length:	186	Identity:	72/186 - (38%)
Similarity:	97/186 - (52%)	Gaps:	11/186 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 RTYRRVSPNVKHEKL----TANVDDDFKAGSTTKRR--NCER-----SPKICDVCGNTYKYQHAL 320
            :.:|..|....|:|:    .:.:..|...|...|.|  |.:|     .|..|.:||..:..:..|
Human   267 KAFRWKSQLNAHQKIHTGEKSYICSDCGKGFIKKSRLINHQRVHTGEKPHGCSLCGKAFSKRSRL 331

  Fly   321 NAHMRRHNNERPYSCEVCQKAFISNVELRRHMRVHTGQKPYSCRHCERRFSDFGSSKKHERIHTG 385
            ..|.|.|..|:||.|..|.|||....:|..|.:.|||:|.|.||.|.:.|...|:...|:|||||
Human   332 TEHQRTHTGEKPYECTECDKAFRWKSQLNAHQKAHTGEKSYICRDCGKGFIQKGNLIVHQRIHTG 396

  Fly   386 ERPYVCEVCNKGFAYAHVLSAHRRTHTGKKQFQCTQCDKGFTKKTYLSAHMEQHRG 441
            |:||:|..|.|||.....|..|||||||:|.:.|.:|.|||::||.|.:|...|.|
Human   397 EKPYICNECGKGFIQKGNLLIHRRTHTGEKPYVCNECGKGFSQKTCLISHQRFHTG 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9215	NP_573045.1	zf-AD	16..92	CDD:285071
		DUF2117	165..>273	CDD:303038	1/5 (20%)
		COG5048	<303..439	CDD:227381	60/135 (44%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		zf-H2C2_2	319..344	CDD:290200	12/24 (50%)
		zf-C2H2	333..355	CDD:278523	8/21 (38%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		zf-H2C2_2	347..371	CDD:290200	10/23 (43%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..400	CDD:290200	14/24 (58%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		zf-H2C2_2	404..427	CDD:290200	13/22 (59%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
ZNF613	NP_001026891.2	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	176..531	CDD:227381	72/186 (39%)
		C2H2 Zn finger	206..226	CDD:275368
		C2H2 Zn finger	234..254	CDD:275368
		zf-H2C2_2	247..269	CDD:290200	0/1 (0%)
		C2H2 Zn finger	262..282	CDD:275368	4/14 (29%)
		C2H2 Zn finger	290..310	CDD:275368	6/19 (32%)
		C2H2 Zn finger	318..338	CDD:275368	6/19 (32%)
		zf-H2C2_2	331..353	CDD:290200	10/21 (48%)
		C2H2 Zn finger	346..366	CDD:275368	7/19 (37%)
		C2H2 Zn finger	374..394	CDD:275368	7/19 (37%)
		zf-H2C2_2	386..411	CDD:290200	14/24 (58%)
		C2H2 Zn finger	402..422	CDD:275368	9/19 (47%)
		zf-H2C2_2	414..439	CDD:290200	14/24 (58%)
		C2H2 Zn finger	430..450	CDD:275368	9/19 (47%)
		C2H2 Zn finger	458..478	CDD:275368
		zf-H2C2_2	471..493	CDD:290200
		zf-C2H2	484..506	CDD:278523
		C2H2 Zn finger	486..506	CDD:275368
		zf-H2C2_2	499..523	CDD:290200
		C2H2 Zn finger	514..530	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24404
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100