DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9215 and znf148

DIOPT Version :9

Sequence 1:	NP_573045.1	Gene:	CG9215 / 32494	FlyBaseID:	FBgn0030659	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001073649.1	Gene:	znf148 / 560300	ZFINID:	ZDB-GENE-030131-8769	Length:	808	Species:	Danio rerio

Alignment Length:	564	Identity:	117/564 - (20%)
Similarity:	193/564 - (34%)	Gaps:	212/564 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 PMLVDKQQEQLKLDLEQAHVRLPATLKIRRLNVEPCSSSSVSGTITTSTEPSEDVKEEKTDSLSL 179
            |..||.:..:..||:         ||..|.|...|..:           |..:|..||:.|...|
Zfish    28 PSRVDGRGRRGSLDM---------TLGERSLANHPLLA-----------EDDDDEDEEEDDDDDL 72

  Fly   180 IPDGAMVLSLNDFQAQDSITQQAEEKDPKKQQDEDEGQAKMLELDPWDDENTPEHL------YEI 238
            ..:|   |:.:|..:||.:....|..       :::||          ||....|.      |.:
Zfish    73 AGEG---LTSHDLISQDDLMVHEETV-------KNDGQ----------DEAAFSHRISNKLHYTL 117

  Fly   239 ETPL-------IEESVVASPPLPLPPTHPANQQKKRTYRRVSPNVKHEKLTANVDDDFKAGSTTK 296
            ..|:       :.:|::.:.....|...|::..||:..::.||   .:.||.|.|     ||.
Zfish   118 SMPVNIKQEMKVPDSLILNKKEKKPGRDPSDCHKKKKRKQRSP---AKILTINED-----GSL-- 172

  Fly   297 RRNCERSPKICDVCGNTYKYQHALNAHMRRHNNERPYSCEVCQKAFISNVELRRHMRVHTGQKPY 361
                                         .|.|.:.:.||.|..||.:|..|:||:.:|||:||:
Zfish   173 -----------------------------GHQNPKSHICEHCNAAFRTNYHLQRHVFIHTGEKPF 208

  Fly   362 SCRHCERRFSDFGSSKKHERIHTGERPYVCEVCNKGFAYAHVLSAHRRTHTGKKQFQCTQCDKGF 426
            .|..|:.||......::||:|||||:|:.|:.|...|...:.:..|:|||:|:|.:||..|.:.|
Zfish   209 QCNQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMKFIQKYHMERHKRTHSGEKPYQCDYCHQFF 273

  Fly   427 TKKTYLSAHME-----------------------------------------QHRGSGNGEASVA 450
            ::...:..|..                                         :.:.|....||:.
Zfish   274 SRTDRVLKHRRMCHENKDRKVQKTAVKDSPLRTPENLGFSFPAKDCTLPKKTRQKTSDKSRASIT 338

  Fly   451 SSS------ADASSRNQNASARKE----------------------------------------- 468
            :.:      ||...:.::..|:.|
Zfish   339 NPAVDKVVEADMDEKTEDRLAKSECLPLYAVATKVKDEYVVTDYSVELPDSPPGSRHLAGEESND 403

  Fly   469 --------------SAR--KQQQIPESFSLDSV-ELEQTKVLEEC--IVANDFMFNEEDNAEQEA 514
                          |.|  |||.:.:|.||..: ..|::||....  ||.|..:.:.|.|.:.|:
Zfish   404 EIISPPKLVLKKIASRRGFKQQALEQSQSLSPLSSFEESKVTRYTFEIVDNKGLLDVETNPDMES 468

  Fly   515 NDREGLQHDDSYPYVGGYQSVDSVKELVGDLLDTEEFCDESKYM 558
              .|.||...:.| .|...:.|          |..:|..:.:|:
Zfish   469 --VEALQVGQAKP-TGSSTNYD----------DAMQFVKKRRYL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9215	NP_573045.1	zf-AD	16..92	CDD:285071
		DUF2117	165..>273	CDD:303038	23/120 (19%)
		COG5048	<303..439	CDD:227381	42/176 (24%)
		C2H2 Zn finger	307..327	CDD:275368	0/19 (0%)
		zf-H2C2_2	319..344	CDD:290200	7/24 (29%)
		zf-C2H2	333..355	CDD:278523	9/21 (43%)
		C2H2 Zn finger	335..355	CDD:275368	9/19 (47%)
		zf-H2C2_2	347..371	CDD:290200	11/23 (48%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..400	CDD:290200	11/24 (46%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	404..427	CDD:290200	9/22 (41%)
		C2H2 Zn finger	419..439	CDD:275368	4/60 (7%)
znf148	NP_001073649.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..86		19/80 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..162		7/33 (21%)
		C2H2 Zn finger	147..165	CDD:275370	4/20 (20%)
		zf-C2H2	180..202	CDD:278523	9/21 (43%)
		C2H2 Zn finger	182..202	CDD:275368	9/19 (47%)
		zf-H2C2_2	194..219	CDD:290200	12/24 (50%)
		C2H2 Zn finger	210..230	CDD:275368	6/19 (32%)
		zf-H2C2_2	223..247	CDD:290200	11/23 (48%)
		C2H2 Zn finger	238..258	CDD:275368	5/19 (26%)
		zf-H2C2_2	250..275	CDD:290200	10/24 (42%)
		C2H2 Zn finger	266..284	CDD:275368	4/17 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..338		3/32 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..617
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	705..736
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24404
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100