DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9215 and ZNF821

DIOPT Version :9

Sequence 1:	NP_573045.1	Gene:	CG9215 / 32494	FlyBaseID:	FBgn0030659	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001188481.1	Gene:	ZNF821 / 55565	HGNCID:	28043	Length:	412	Species:	Homo sapiens

Alignment Length:	348	Identity:	80/348 - (22%)
Similarity:	125/348 - (35%)	Gaps:	102/348 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 DFQAQDSITQQAEEKDPKKQQDEDEGQAKMLELDPWDDENTPEHLYEIETPLIEE--SVVASPPL 253
            |..:|....||..::|  ....:.||          |:|.|.:.  |:.:...||  .||
Human    37 DLGSQRQAIQQLRDQD--SSSSDSEG----------DEEETTQD--EVSSHTSEEDGGVV----- 82

  Fly   254 PLPPTHPANQQKKRTYRRVSPN--VKHEKLTANVDDDFKAGSTTKRRNCERSPKI----CDVCGN 312
                  ...::.:.|.:.|..|  |:|| :|.|::.|               |.:    |.:|..
Human    83 ------KVEKELENTEQPVGGNEVVEHE-VTGNLNSD---------------PLLELCQCPLCQL 125

  Fly   313 TYKYQHALNAHMRRHN----NERPYSCEVCQKAFISNVELRRHMRVHTGQKPYSCRHCERRFSD- 372
            ....:..|.||:.:|.    :.:.|.|.||.:|..|...|.||:.:|:..:..:|..|..||:.
Human   126 DCGSREQLIAHVYQHTAAVVSAKSYMCPVCGRALSSPGSLGRHLLIHSEDQRSNCAVCGARFTSH 190

  Fly   373 --FGSSKKHERIHTGERPYVCEVCNKGFAYAHVLSAHRRTHTGKKQFQCTQCDKGFTKKTYLSAH 435
              |.|.|..|.::....|   .|.|:|.:.|.          ||        |..|:...|.:
Human   191 ATFNSEKLPEVLNMESLP---TVHNEGPSSAE----------GK--------DIAFSPPVYPA-- 232

  Fly   436 MEQHRGSGNGEASVASSSADASS--RNQNASARKESARKQQQIPESFSLDSVELEQTKVLEECIV 498
                     |...|.::.|....  ..|..|.||.:.|:|.: |....|..:|.|:|
Human   233 ---------GILLVCNNCAAYRKLLEAQTPSVRKWALRRQNE-PLEVRLQRLERERT-------- 279

  Fly   499 ANDFMFNEEDNAEQEA---NDRE 518
            |.....:.|...|:|.   .|||
Human   280 AKKSRRDNETPEEREVRRMRDRE 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9215	NP_573045.1	zf-AD	16..92	CDD:285071
		DUF2117	165..>273	CDD:303038	16/83 (19%)
		COG5048	<303..439	CDD:227381	35/146 (24%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		zf-H2C2_2	319..344	CDD:290200	9/28 (32%)
		zf-C2H2	333..355	CDD:278523	9/21 (43%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		zf-H2C2_2	347..371	CDD:290200	7/23 (30%)
		C2H2 Zn finger	363..383	CDD:275368	8/22 (36%)
		zf-H2C2_2	375..400	CDD:290200	7/24 (29%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		zf-H2C2_2	404..427	CDD:290200	3/22 (14%)
		C2H2 Zn finger	419..439	CDD:275368	3/19 (16%)
ZNF821	NP_001188481.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..83		15/70 (21%)
		C2H2 Zn finger	120..140	CDD:275368	5/19 (26%)
		zf-C2H2	150..172	CDD:395048	9/21 (43%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		U2AF_lg	275..>387	CDD:273727	10/36 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..319		8/33 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24404
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100