DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9215 and GFI1

DIOPT Version :9

Sequence 1:	NP_573045.1	Gene:	CG9215 / 32494	FlyBaseID:	FBgn0030659	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001120687.1	Gene:	GFI1 / 2672	HGNCID:	4237	Length:	422	Species:	Homo sapiens

Alignment Length:	146	Identity:	56/146 - (38%)
Similarity:	82/146 - (56%)	Gaps:	0/146 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 KRRNCERSPKICDVCGNTYKYQHALNAHMRRHNNERPYSCEVCQKAFISNVELRRHMRVHTGQKP 360
            :|.:....|..|::||.|:.:..:|..|...|:.||.:.|::|.|:|..:..|..|:.:|:..:|
Human   275 RRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRP 339

  Fly   361 YSCRHCERRFSDFGSSKKHERIHTGERPYVCEVCNKGFAYAHVLSAHRRTHTGKKQFQCTQCDKG 425
            |.|::|.:||......|||..|||||:|:.|:||.|.|:.:..|..|.|.|||.|.|.|..|.||
Human   340 YPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKG 404

  Fly   426 FTKKTYLSAHMEQHRG 441
            |.:|..|..|.|...|
Human   405 FQRKVDLRRHRETQHG 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9215	NP_573045.1	zf-AD	16..92	CDD:285071
		DUF2117	165..>273	CDD:303038
		COG5048	<303..439	CDD:227381	54/135 (40%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		zf-H2C2_2	319..344	CDD:290200	9/24 (38%)
		zf-C2H2	333..355	CDD:278523	6/21 (29%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		zf-H2C2_2	347..371	CDD:290200	8/23 (35%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..400	CDD:290200	14/24 (58%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		zf-H2C2_2	404..427	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
GFI1	NP_001120687.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..109
		SNAG domain. /evidence=ECO:0000250	1..20
		Required for interaction with RELA. /evidence=ECO:0000269\|PubMed:20547752	140..257
		COG5048	<254..416	CDD:227381	54/140 (39%)
		C2H2 Zn finger	257..278	CDD:275368	1/2 (50%)
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
		C2H2 Zn finger	398..417	CDD:275368	8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24404
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100