DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9215 and Zfp382

DIOPT Version :9

Sequence 1:	NP_573045.1	Gene:	CG9215 / 32494	FlyBaseID:	FBgn0030659	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001074476.1	Gene:	Zfp382 / 233060	MGIID:	3588204	Length:	579	Species:	Mus musculus

Alignment Length:	544	Identity:	128/544 - (23%)
Similarity:	206/544 - (37%)	Gaps:	146/544 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 QLDSSPSQLQRWPDKICKQ-CHLELSVSYRFH-EKCTAVQKLFRSASRSTSTSAVFAAAAAAPPA 114
            :||  |:|...:.|.:.:. ||.   :|..|| .|...::||  .......|..:|       |:
Mouse    58 RLD--PAQKALYRDVMLENYCHF---ISVGFHITKPDMIRKL--EQGEELWTERIF-------PS 108

  Fly   115 PMLVDKQQEQLKL-DLEQAHVRLPATLKIRRLNVEPCSSSSVSGTITTSTEPSEDVKEEKTDSLS 178
            ...:::::..:|. |.:....:....:|.::|..|   .|||.|         |.:.:.:..|.:
Mouse   109 QSYLEEEEVLVKFSDYQDKPPKSIVIIKHKKLIKE---RSSVYG---------EALGKNRVVSKT 161

  Fly   179 LI---PDGAMVLSLNDFQAQD-----------------SITQQAEEKDPKKQQDEDEGQAKMLEL 223
            |.   .||.::.::::|.::|                 .:|.:.|:..|.....:..|:|...|.
Mouse   162 LFEYKSDGKVLKNISEFISRDINPAMGKLGGSKEWEGSILTSKQEKTHPASILHKQIGRALSSEW 226

  Fly   224 DPWDDENT--PEHLYE------------IETP-------------------LIEESVVASPPLPL 255
            |....:.|  ||..:|            :|.|                   |.|:|.:...|..|
Mouse   227 DLAQHQKTQIPEQRFEYNKCDSSFLMTGVEFPHGRAHRGGGNFNYSKDDITLFEKSDLGIHPHDL 291

  Fly   256 PP--------------------THPANQQKKR---------TYRRVSPNVKHEKLTANVDDDFKA 291
            ..                    .||::|..:|         ::||.|..::||::
Mouse   292 MEKKCSSYNKYGELLCRKSVFVMHPSSQMDERPFQCPYCGNSFRRKSYLIEHERI---------- 346

  Fly   292 GSTTKRRNCERSPKICDVCGNTYKYQHALNAHMRRHNNERPYSCEVCQKAFISNVELRRHMRVHT 356
                   :....|.||..||..::.:.||..|.:.|...:||.|..|.|:|.....|.||.:.||
Mouse   347 -------HTGEKPYICCQCGRAFRQKTALTLHEKTHTEGKPYLCVDCGKSFRQKATLTRHHKAHT 404

  Fly   357 GQKPYSCRHCERRFSDFGSSKKHERIHTGERPYVCEVCNKGFAYAHVLSAHRRTHTGKKQFQCTQ 421
            |:|.|.|..|...|........|:|.||||:||.|..|.|.|.....|:.|:|||||:|.:.|::
Mouse   405 GEKAYECTQCGSAFGKKSYLIDHQRTHTGEKPYQCTECGKAFIQKTTLTVHQRTHTGEKPYICSE 469

  Fly   422 CDKGFTKKTYLSAHMEQHRGSGNGEASVASSSADASSRNQ---NASARKESARKQQQIPE---SF 480
            |.|.|.:||.|:.|...|    .||.....|....|.|.:   ....|..:..|....|:   :|
Mouse   470 CGKSFCQKTTLTLHQRIH----TGEKPYICSDCGKSFRQKAILTVHYRIHTGEKSNGCPQCGKAF 530

  Fly   481 SLDSVELEQTKV--------LEEC 496
            |..|..:...|:        .:||
Mouse   531 SRKSNLIRHQKIHTGEKPYECQEC 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9215	NP_573045.1	zf-AD	16..92	CDD:285071	12/41 (29%)
		DUF2117	165..>273	CDD:303038	31/189 (16%)
		COG5048	<303..439	CDD:227381	54/135 (40%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		zf-H2C2_2	319..344	CDD:290200	10/24 (42%)
		zf-C2H2	333..355	CDD:278523	8/21 (38%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		zf-H2C2_2	347..371	CDD:290200	10/23 (43%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		zf-H2C2_2	375..400	CDD:290200	12/24 (50%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	404..427	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
Zfp382	NP_001074476.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Mediates interaction with TRIM28. /evidence=ECO:0000250	12..135		18/90 (20%)
		Represses transcription. /evidence=ECO:0000250	40..81		7/27 (26%)
		KRAB	42..102	CDD:214630	13/50 (26%)
		KRAB	42..81	CDD:279668	7/27 (26%)
		Represses transcription. /evidence=ECO:0000250	105..240		28/153 (18%)
		C2H2 Zn finger	303..319	CDD:275368	2/15 (13%)
		Required for transcriptional repression activity, probably mediates sequence-specific DNA-binding. /evidence=ECO:0000250	325..579		74/251 (29%)
		zf-C2H2	325..347	CDD:278523	5/38 (13%)
		C2H2 Zn finger	327..347	CDD:275368	5/36 (14%)
		zf-H2C2_2	339..364	CDD:290200	7/41 (17%)
		C2H2 Zn finger	355..375	CDD:275368	6/19 (32%)
		C2H2 Zn finger	383..403	CDD:275368	7/19 (37%)
		COG5048	<411..562	CDD:227381	46/148 (31%)
		C2H2 Zn finger	411..431	CDD:275368	5/19 (26%)
		zf-H2C2_2	423..448	CDD:290200	12/24 (50%)
		C2H2 Zn finger	439..459	CDD:275368	7/19 (37%)
		zf-H2C2_2	452..474	CDD:290200	11/21 (52%)
		C2H2 Zn finger	467..487	CDD:275368	8/19 (42%)
		zf-H2C2_2	480..504	CDD:290200	7/27 (26%)
		C2H2 Zn finger	495..515	CDD:275368	4/19 (21%)
		C2H2 Zn finger	523..543	CDD:275368	5/19 (26%)
		zf-C2H2	523..543	CDD:278523	5/19 (26%)
		zf-H2C2_2	535..560	CDD:290200	3/20 (15%)
		C2H2 Zn finger	551..571	CDD:275368	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24404
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100