DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9215 and Zfp281

DIOPT Version :9

Sequence 1:	NP_573045.1	Gene:	CG9215 / 32494	FlyBaseID:	FBgn0030659	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001153723.1	Gene:	Zfp281 / 226442	MGIID:	3029290	Length:	893	Species:	Mus musculus

Alignment Length:	452	Identity:	99/452 - (21%)
Similarity:	159/452 - (35%)	Gaps:	145/452 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 STSTSAVFAAAAAAPPAPMLVDKQQEQLKLDLEQAHVRLPATLKIRRLNVEPCSSSSVSGTITTS 162
            |:||||..||....||||.:..|:                          ||.:|::...:..||
Mouse    78 SSSTSAAPAAEPPPPPAPDMTFKK--------------------------EPAASAAAFPSQRTS 116

  Fly   163 ---TEPSEDVKEEKTDSLSLIPDGAMVLSLNDFQAQDS-----------ITQQAEEKDP------ 207
               .:....:|:||.               .|.:.|.|           :...|||:.|
Mouse   117 WGFLQSLVSIKQEKP---------------ADPEEQPSHHHHHHHHYGGLFAGAEERSPGLGGGE 166

  Fly   208 ----------------KKQQDEDEGQAKMLELDPWDDENTPEHLYEIETPLIEESVVASPPLPLP 256
                            .:||.....:..:|......||:..:.
Mouse   167 GGSHGVIQDLSLLHQHAQQQPAQHHRDVLLSSGSRTDEHGNQE---------------------- 209

  Fly   257 PTHPANQQKKRTYRRVSPNVKHEKLTANVDDDFKAGSTTKRRNCE---------RSPKICDVCGN 312
            |...||.:|.:..:..|..:|.::         |..:::|....|         :.|.|||.|..
Mouse   210 PKQDANVKKAKRPKPESQGIKAKR---------KPSASSKPLVGEGEGAVLSPSQKPHICDHCSA 265

  Fly   313 TYKYQHALNAHMRRHNNERPYSCEVCQKAFISNVELRRHMRVHTGQKPYSCRHCERRFSDFGSSK 377
            .::..:.|..|:..|..|||:.|..|...||....|:||.::|:.:||:.|..|..:|......:
Mouse   266 AFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHME 330

  Fly   378 KHERIHTGERPYVCEVCNKGFAYAHVLSAHRRTHTGKKQFQCTQCDKGFTKKTYLSAHMEQHRGS 442
            :|:|.|:||:||.|:.|.:.|:....|..||||           |.:...|.   :|..|.  ||
Mouse   331 RHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRT-----------CGEAIAKG---AASAEP--GS 379

  Fly   443 GN----GEASVASSSADASSRNQNAS--------ARKESARKQQQIPESFSLDSVELEQTKV 492
            .|    |..:|.|....:|||.::.|        ..|.....:.|:..:.::.|..:|...|
Mouse   380 SNHNSMGNLAVLSQGNTSSSRRKSKSKSIAIENKEHKTGKTNESQMSNNINMQSYSVEMPTV 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9215	NP_573045.1	zf-AD	16..92	CDD:285071
		DUF2117	165..>273	CDD:303038	19/140 (14%)
		COG5048	<303..439	CDD:227381	43/135 (32%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		zf-H2C2_2	319..344	CDD:290200	9/24 (38%)
		zf-C2H2	333..355	CDD:278523	7/21 (33%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		zf-H2C2_2	347..371	CDD:290200	8/23 (35%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		zf-H2C2_2	375..400	CDD:290200	10/24 (42%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	404..427	CDD:290200	6/22 (27%)
		C2H2 Zn finger	419..439	CDD:275368	4/19 (21%)
Zfp281	NP_001153723.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..113		15/60 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..148		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..172		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..251		11/83 (13%)
		zf-C2H2	258..280	CDD:278523	6/21 (29%)
		C2H2 Zn finger	260..280	CDD:275368	5/19 (26%)
		zf-H2C2_2	272..297	CDD:290200	9/24 (38%)
		C2H2 Zn finger	288..308	CDD:275368	7/19 (37%)
		zf-H2C2_2	301..325	CDD:290200	9/23 (39%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		zf-H2C2_2	328..353	CDD:290200	10/24 (42%)
		C2H2 Zn finger	344..363	CDD:275368	6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..425		13/58 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..658
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	775..815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24404
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100