DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9215 and ZNF497

DIOPT Version :9

Sequence 1:	NP_573045.1	Gene:	CG9215 / 32494	FlyBaseID:	FBgn0030659	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001193938.1	Gene:	ZNF497 / 162968	HGNCID:	23714	Length:	498	Species:	Homo sapiens

Alignment Length:	186	Identity:	59/186 - (31%)
Similarity:	97/186 - (52%)	Gaps:	11/186 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 RTYRRVSPNVKHEKL--------TANVDDDFKAGS---TTKRRNCERSPKICDVCGNTYKYQHAL 320
            :.:|..|..::|::.        .|.....|..||   ..:|.:....|..|..||..:..:..|
Human   309 KAFRESSQLLQHQRTHTGERPFECAECGQAFVMGSYLAEHRRVHTGEKPHACAQCGKAFSQRSNL 373

  Fly   321 NAHMRRHNNERPYSCEVCQKAFISNVELRRHMRVHTGQKPYSCRHCERRFSDFGSSKKHERIHTG 385
            .:|.|.|:..:|::|..|.|||..:..|..|...|||::|::|..|.:.|......::|:|:|:|
Human   374 LSHRRTHSGAKPFACADCGKAFRGSSGLAHHRLSHTGERPFACAECGKAFRGSSELRQHQRLHSG 438

  Fly   386 ERPYVCEVCNKGFAYAHVLSAHRRTHTGKKQFQCTQCDKGFTKKTYLSAHMEQHRG 441
            |||:||..|:|.|.....|.:|||||||::.:.|.:|.|.|:.:..|:.|.::|.|
Human   439 ERPFVCAHCSKAFVRKSELLSHRRTHTGERPYACGECGKPFSHRCNLNEHQKRHGG 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9215	NP_573045.1	zf-AD	16..92	CDD:285071
		DUF2117	165..>273	CDD:303038	1/5 (20%)
		COG5048	<303..439	CDD:227381	49/135 (36%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		zf-H2C2_2	319..344	CDD:290200	10/24 (42%)
		zf-C2H2	333..355	CDD:278523	7/21 (33%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		zf-H2C2_2	347..371	CDD:290200	8/23 (35%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		zf-H2C2_2	375..400	CDD:290200	12/24 (50%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		zf-H2C2_2	404..427	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
ZNF497	NP_001193938.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..104
		COG5048	107..492	CDD:227381	57/182 (31%)
		C2H2 Zn finger	108..128	CDD:275368
		zf-H2C2_2	120..144	CDD:290200
		C2H2 Zn finger	136..156	CDD:275368
		zf-H2C2_2	148..171	CDD:290200
		C2H2 Zn finger	164..184	CDD:275368
		zf-C2H2	190..212	CDD:278523
		C2H2 Zn finger	192..212	CDD:275368
		zf-H2C2_2	205..228	CDD:290200
		C2H2 Zn finger	220..240	CDD:275368
		C2H2 Zn finger	248..268	CDD:275368
		C2H2 Zn finger	276..296	CDD:275368
		zf-H2C2_2	289..311	CDD:290200	0/1 (0%)
		C2H2 Zn finger	304..324	CDD:275368	3/14 (21%)
		zf-H2C2_2	317..340	CDD:290200	2/22 (9%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		zf-H2C2_2	344..369	CDD:290200	5/24 (21%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		C2H2 Zn finger	416..436	CDD:275368	5/19 (26%)
		zf-H2C2_2	428..453	CDD:290200	12/24 (50%)
		C2H2 Zn finger	444..464	CDD:275368	8/19 (42%)
		zf-H2C2_2	456..481	CDD:290200	12/24 (50%)
		C2H2 Zn finger	472..492	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24404
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100