DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9215 and CTCF

DIOPT Version :9

Sequence 1:	NP_573045.1	Gene:	CG9215 / 32494	FlyBaseID:	FBgn0030659	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_006556.1	Gene:	CTCF / 10664	HGNCID:	13723	Length:	727	Species:	Homo sapiens

Alignment Length:	608	Identity:	121/608 - (19%)
Similarity:	197/608 - (32%)	Gaps:	249/608 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 APPAPMLVDKQQ---------EQLKL---DLEQAHVRLPATLKIRRLNVEPCSSSSVSGTITTST 163
            ||.|...||..|         |:..:   :|:...|.:|.|:.:...:||....:
Human    83 APEAEAAVDDTQIITLQVVNMEEQPINIGELQLVQVPVPVTVPVATTSVEELQGA---------- 137

  Fly   164 EPSEDVKEEKTDSLSLI------PDGAMVLSLNDFQAQDSITQQAE---EKDPKKQQDED----- 214
            ..:|..||...:|..:|      |:|..|:.:. ...:....:|.|   ::||..|:|.|
Human   138 YENEVSKEGLAESEPMICHTLPLPEGFQVVKVG-ANGEVETLEQGELPPQEDPSWQKDPDYQPPA 201

  Fly   215 ---------------EGQAKMLELDPWDDENTPEHLYEIETPLIEESVVAS--PPLPLPPTHPAN 262
                           ||:...:.:..:::|.....|.|:..    |.||.:  ||   .||....
Human   202 KKTKKTKKSKLRYTEEGKDVDVSVYDFEEEQQEGLLSEVNA----EKVVGNMKPP---KPTKIKK 259

  Fly   263 QQKKRTY----------RRVSPNVKHEKLTANVDDDFKAGSTTKRRNCERSPKICDVCG------ 311
            :..|:|:          ||           :|:|...|:       :.:..|..|.:||
Human   260 KGVKKTFQCELCSYTCPRR-----------SNLDRHMKS-------HTDERPHKCHLCGRAFRTV 306

  Fly   312 -------NT---------------------------YKYQH-----------------ALNAHMR 325
                   ||                           ||:.|                 .|..|:|
Human   307 TLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIR 371

  Fly   326 RHNNERPYSCEVCQKAFISNVELRRHMRVHTGQKPYSCRHCERRFSDFGSSK------------- 377
            .|..|||:.|.:|..|.....:|:||||.|:|:|||.|..|..||:..|:.|
Human   372 SHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAK 436

  Fly   378 -----------------------------------------------KHERIHTGERPYVCEVCN 395
                                                           :|::.|..|:.:.|:.|:
Human   437 FHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCD 501

  Fly   396 KGFAYAHVLSAHRRTHTGKKQFQCTQCDKGFTKKTYLSAHMEQHRGSGNGEASVASSSADASSRN 460
            ........:..|:|||||:|.:.|:.|||.|.:|..|..|.:::.......|:...|....:...
Human   502 YACRQERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTR 566

  Fly   461 QNASAR-------------------KESARKQQQIPESFSLDSVELEQTKVLEECIVANDFMFNE 506
            :|..||                   |:|.|.:::...|...||                    ::
Human   567 RNTMARHADNCAGPDGVEGENGGETKKSKRGRKRKMRSKKEDS--------------------SD 611

  Fly   507 EDNAEQEANDREGLQHDDSYPYV 529
            .:|||.:.:|.|    |:..|.|
Human   612 SENAEPDLDDNE----DEEEPAV 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9215	NP_573045.1	zf-AD	16..92	CDD:285071
		DUF2117	165..>273	CDD:303038	31/148 (21%)
		COG5048	<303..439	CDD:227381	55/252 (22%)
		C2H2 Zn finger	307..327	CDD:275368	11/76 (14%)
		zf-H2C2_2	319..344	CDD:290200	10/24 (42%)
		zf-C2H2	333..355	CDD:278523	8/21 (38%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		zf-H2C2_2	347..371	CDD:290200	13/23 (57%)
		C2H2 Zn finger	363..383	CDD:275368	7/79 (9%)
		zf-H2C2_2	375..400	CDD:290200	6/84 (7%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		zf-H2C2_2	404..427	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
CTCF	NP_006556.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..211		7/30 (23%)
		zf-H2C2_5	266..289	CDD:404746	5/40 (13%)
		C2H2 Zn finger	268..288	CDD:275368	5/37 (14%)
		zf-H2C2_2	280..305	CDD:404364	7/31 (23%)
		C2H2 Zn finger	296..316	CDD:275368	4/19 (21%)
		zf-H2C2_2	309..333	CDD:404364	2/23 (9%)
		C2H2 Zn finger	324..347	CDD:275368	2/22 (9%)
		zf-H2C2_5	351..375	CDD:404746	4/23 (17%)
		C2H2 Zn finger	353..373	CDD:275368	3/19 (16%)
		COG5048	<366..500	CDD:227381	30/133 (23%)
		C2H2 Zn finger	381..401	CDD:275368	8/19 (42%)
		C2H2 Zn finger	409..426	CDD:275368	6/16 (38%)
		C2H2 Zn finger	439..457	CDD:275368	0/17 (0%)
		C2H2 Zn finger	469..489	CDD:275368	1/19 (5%)
		C2H2 Zn finger	497..517	CDD:275368	4/19 (21%)
		zf-H2C2_2	509..534	CDD:404364	12/24 (50%)
		C2H2 Zn finger	525..546	CDD:275368	8/20 (40%)
		C2H2 Zn finger	557..573	CDD:275368	3/15 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..677		14/82 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	689..717
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24404
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100