DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9215 and ctcf

DIOPT Version :9

Sequence 1:	NP_573045.1	Gene:	CG9215 / 32494	FlyBaseID:	FBgn0030659	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001116268.1	Gene:	ctcf / 100101689	XenbaseID:	XB-GENE-862914	Length:	734	Species:	Xenopus tropicalis

Alignment Length:	489	Identity:	115/489 - (23%)
Similarity:	191/489 - (39%)	Gaps:	125/489 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 LVDKQQEQLKLDLEQAHVRLPATLKIRRLNVEPCSSSSVSGTITTSTEPSEDVKEEKTDSLSLI- 180
            :|:.:::.:.|. |...|::|..:        |.:::|| |.:..:.| :|..||...:...:|
Frog   100 VVNMEEQPINLG-ELQLVQVPVAV--------PMATTSV-GELHAAFE-NEVSKEGLQEGEPMIC 153

  Fly   181 -----PDGAMVLSLN-----DFQAQDSITQQAE---EKDP------KKQQDEDEGQAKMLELDPW 226
                 |:|..|:.:.     :...|..:.||.|   :|||      ||.:...:.:.:..|
Frog   154 HTLPLPEGFQVVKVGANGEVETLEQAELQQQEEPGWQKDPDYVPPIKKTKKTKKSKLRYTE---- 214

  Fly   227 DDENTPEHLYEIETPLIE--------ESVVAS--PPLPLPPTHPANQQKKRTY----------RR 271
            :.::....:|:.|....|        |.||.:  ||   .||....:..|:|:          ||
Frog   215 EGKDVDVSVYDFEEEQQEGLLSDVNAEKVVGNMKPP---KPTKIKKKGVKKTFQCELCSYTCPRR 276

  Fly   272 VSPNVKHEKLTANVDDDFKAGSTTKRRNCERSPKICDVCGNTYKYQHALNAHMRRHNNERPYSCE 336
                       :|:|...|:       :.:..|..|.:||..::....|..|:..|...||:.|.
Frog   277 -----------SNLDRHMKS-------HTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP 323

  Fly   337 VCQKAFISNVELRRHMRV-HTGQKPYSCRHCERRFSDFGSSKKHERIHTGERPYVCEVCNKGFAY 400
            .|..||:::.||.||.|. ||.:||:.|..|:....:....|:|.|.||||||:.|.:|:.....
Frog   324 DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRD 388

  Fly   401 AHVLSAHRRTHTGKKQFQCTQCDKGFTKKTYLSAH-MEQHRGSGNGEASVASSSADASSRNQNAS 464
            .:.|..|.|||:|:|.::|..|...||:...:..| :::|.   ...|.......|      ...
Frog   389 TYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHT---ENVAKFHCPHCD------TVI 444

  Fly   465 ARKES----ARKQQQIPESFSLDSVELEQTKVLEECIVANDFMFNEEDNAEQEANDREGLQHDDS 525
            |||..    .|||...          :||.|....|    |.:|:|.
Frog   445 ARKSDLGVHLRKQHSY----------IEQGKKCRYC----DTVFHER------------------ 477

  Fly   526 YPYVGGYQSVDSVKELVGDLLDTEEFCDESKYMI 559
            |..:...:|..:.|....|  ..|..|.:.::||
Frog   478 YALIQHQKSHKNEKRFKCD--QCEYACRQERHMI 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9215	NP_573045.1	zf-AD	16..92	CDD:285071
		DUF2117	165..>273	CDD:303038	31/147 (21%)
		COG5048	<303..439	CDD:227381	47/137 (34%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		zf-H2C2_2	319..344	CDD:290200	9/24 (38%)
		zf-C2H2	333..355	CDD:278523	9/22 (41%)
		C2H2 Zn finger	335..355	CDD:275368	9/20 (45%)
		zf-H2C2_2	347..371	CDD:290200	11/24 (46%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		zf-H2C2_2	375..400	CDD:290200	11/24 (46%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	404..427	CDD:290200	9/22 (41%)
		C2H2 Zn finger	419..439	CDD:275368	5/20 (25%)
ctcf	NP_001116268.1	zf-H2C2_5	264..287	CDD:372805	5/40 (13%)
		C2H2 Zn finger	266..286	CDD:275368	5/37 (14%)
		zf-H2C2_2	278..303	CDD:372612	7/31 (23%)
		C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		zf-H2C2_2	307..331	CDD:372612	9/23 (39%)
		C2H2 Zn finger	322..345	CDD:275368	10/22 (45%)
		zf-H2C2_5	349..373	CDD:372805	6/23 (26%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		COG5048	<364..498	CDD:227381	43/176 (24%)
		C2H2 Zn finger	379..399	CDD:275368	5/19 (26%)
		C2H2 Zn finger	407..424	CDD:275368	4/16 (25%)
		C2H2 Zn finger	437..455	CDD:275368	4/23 (17%)
		C2H2 Zn finger	467..487	CDD:275368	5/41 (12%)
		C2H2 Zn finger	495..515	CDD:275368	5/17 (29%)
		zf-H2C2_2	507..532	CDD:372612	2/3 (67%)
		C2H2 Zn finger	523..544	CDD:275368
		C2H2 Zn finger	555..571	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24404
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100