DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9213 and Cwf19l2

DIOPT Version :9

Sequence 1:	NP_001285277.1	Gene:	CG9213 / 32490	FlyBaseID:	FBgn0030655	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_081821.1	Gene:	Cwf19l2 / 244672	MGIID:	1918023	Length:	887	Species:	Mus musculus

Alignment Length:	931	Identity:	269/931 - (28%)
Similarity:	380/931 - (40%)	Gaps:	299/931 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IQFESGREKDKARQELREAREAMLQQAKERAELRGQRERQKELRGEADWMLPALAKKLE----KP 64
            ::|||....::.:::.|.||..:|:|||...|...:.|.:|.||.|..||||.:.:::|    :.
Mouse     6 VRFESASSIEERKEQTRNARAEVLRQAKHNFEKEQRGEERKRLRDEDTWMLPDVHERIEQFSQEH 70

  Fly    65 AKKSKKNVSKHKSRSKSKSSKKSRKHRNSSSSSESSTSSSSSFSEDEKERKRRKKKSKRSRKESA 129
            ::|.||...||..:.| |..||.||.:.....|||:.||:|
Mouse    71 SEKKKKKKDKHSKKVK-KEKKKKRKKQKCQKQSESTDSSAS------------------------ 110

  Fly   130 SEDEWVEAPPPLAADNV---------TKKE----PPQRDDWMTSESLLLKTFS----RERKEPAK 177
            ||||||||.|...:|..         |::|    ..|||:|||.:.:.:||.|    :..||..:
Mouse   111 SEDEWVEAAPSQISDKEKTWKVKDKRTEEECDSHDIQRDEWMTIDFMSIKTVSSSSLKAEKETLR 175

  Fly   178 --PNEKAQQIDAYDPAKSGRELNPYWKSNGTGLPG------------------------------ 210
              ..||.|.::.....:  ||||||||..|||||.
Mouse   176 QIEREKTQVLEQSKLLE--RELNPYWKDGGTGLPSKTCILPVTKAKGVEDGGLSWLRKSCQRMKE 238

  Fly   211 ----------------------------------------------------------------- 210

Mouse   239 QAQKENRNFEDIVAEKYGSMEIFQSKLKEAEKIAYKKEDCGWERWRKPTYSDRAQCSQASGTSDL 303

  Fly   211 ----------------------------------------------------------FQKPQDD 217
                                                                      |.:|.|:
Mouse   304 VKCKNLSEDRHLEMEPANSSNYKFSGPDTGKRSGTLQTCRRESALRKNQDSSGNLRSKFLRPSDE 368

  Fly   218 DE-------------------RQAKPH------------SSSSAQGSSRGW--RKPGAKAP---- 245
            ||                   .||..|            ||:|...|.|..  |||..|.|
Mouse   369 DELSFHKRKNFESSSSYSPLVAQASLHCDFRKLTENSEESSASCSRSDRRQENRKPSDKKPLETW 433

  Fly   246 -----------------------SPPRRSRSRSKSATSSDEEEEEAVQQPKSRPSCLTDEQINEL 287
                                   .||.|...:..:.|.:..|.|...        .|..::.|:|
Mouse   434 SYNANQHSTGGRREQLQAESMSCDPPGRGLQQDMTLTIAGPEAESTY--------ILNVDEKNKL 490

  Fly   288 AGKAIKAELKGKKELAAELNQQLEAARKERAEFIASGESVRNANTRPAKSKASAEH-----VLLT 347
            ..|.||||:.|..|||.:|..||:.|.|.:            ....||| :...||     |:|.
Mouse   491 GAKIIKAEMMGNMELAEQLKAQLKEANKFK------------ETQMPAK-RLGVEHEDEQEVILI 542

  Fly   348 KVDQSGNVRPLVQSGDPNESYGGRMGPKRGSKKVDTHVDGQRVRYFADDDRYDIKQMFEREKHAT 412
            :.|:||.:.|:   ..|.|:...: ..:|..|:|.||.|.:|||||.|||...:|.:.:.||..|
Mouse   543 QTDKSGRMWPV---SSPRETLDMK-AERRKRKRVSTHEDKERVRYFPDDDHLSLKDLVKNEKIGT 603

  Fly   413 AAEVNLQYADIVSKHKNPNDD----LDDIFADKVRKQISASDAEKREMQSAIREHEKLVATLDNC 473
            ....|..:..:.||....:|:    |||:|..|..::......|:.:.:.||.||:.|.|.:..|
Mouse   604 DINQNRLFMKMASKFMGKSDEDNYTLDDMFVSKAAEKEHLGKKEESQRRRAIAEHQSLAAKMAKC 668

  Fly   474 ERCFDSAKLDKQLLVSLGDKIYLSLPWYMGLQSGHCILTTLQHVPCCTQLDEDAWEEISNFRKAL 538
            ..||||::..|.|:|::|.|:||.||.:..|..|||.:..|||....|.||||.||||..|||:|
Mouse   669 LYCFDSSQFPKHLIVAIGVKVYLCLPSFQSLTEGHCFIVPLQHHQAATVLDEDVWEEIQMFRKSL 733

  Fly   539 TRMFAARRQDVVFYEIANKLHRRPHLSVHCIPIPASQGEMAPFYFKKAIEESEQEWCINKQLVSL 603
            .:||..:..|.:|.|....|.:..|:...|||:|...|:|||.||||||.||::||.:||:|:.|
Mouse   734 VKMFEDKELDCIFLETNMGLKKHYHMVYECIPLPKEVGDMAPIYFKKAIMESDEEWSMNKKLIDL 798

  Fly   604 RQKSLRAAIPKGLPYVWVHFGMDSGFAHVIEDEDRFPANFAQEILGGMLELNPNAWRKPRKEANP 668
            ..|.:|.::|:||||..|.||:..||||:|||:.|||..|.:||:||||:|.|..|||..:|:..
Mouse   799 SSKDIRKSVPRGLPYFAVDFGLQGGFAHIIEDQYRFPHYFGKEIIGGMLDLEPRLWRKGIRESFE 863

  Fly   669 IGKVKS--FAENWKKFDCTQN 687
            ..:.||  ||:.||.:|.|::
Mouse   864 DQRKKSLQFAQWWKPYDITKS 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9213	NP_001285277.1	CwfJ_C_1	460..584	CDD:282524	55/123 (45%)
CG9213	NP_001285277.1	CwfJ_C_2	593..685	CDD:282523	46/93 (49%)
Cwf19l2	NP_081821.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..143		50/161 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..370		3/54 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..447		10/41 (24%)
		HIT_like	655..779	CDD:294158	55/123 (45%)
		CwfJ_C_2	788..882	CDD:282523	46/93 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849365
Domainoid	1	1.000	123	1.000	Domainoid score	I5600
eggNOG	1	0.900	-	-		E1_KOG2477
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12366
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2567
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003997
OrthoInspector	1	1.000	-	-		oto92152
orthoMCL	1	0.900	-	-		OOG6_103311
Panther	1	1.100	-	-	LDO	PTHR12072
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R275
SonicParanoid	1	1.000	-	-		X2761
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.780