DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9213 and CWF19L2

DIOPT Version :9

Sequence 1:	NP_001285277.1	Gene:	CG9213 / 32490	FlyBaseID:	FBgn0030655	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_689647.2	Gene:	CWF19L2 / 143884	HGNCID:	26508	Length:	894	Species:	Homo sapiens

Alignment Length:	918	Identity:	270/918 - (29%)
Similarity:	394/918 - (42%)	Gaps:	272/918 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QFESGREKDKARQELREAREAMLQQAKERAELRGQRERQKELRGEADWMLPALAKKLEKPAK--- 66
            :|||.:..::.:::.|.||..:|:|||...|...:|:..|.||||..||||.:.:::|:.::
Human    11 RFESAKSIEERKEQTRNARAEVLRQAKANFEKEERRKELKRLRGEDTWMLPDVNERIEQFSQEHS 75

  Fly    67 -KSKKNVSKHKSRSKSKSSKKSRKHRNSSSSSESSTSSSSSFSEDEKERKRRKKKSKRSRKESAS 130
             |.||...||..::|.:..|||:|.: ...::|||.||||                        |
Human    76 VKKKKKKDKHSKKAKKEKKKKSKKQK-YEKNNESSDSSSS------------------------S 115

  Fly   131 EDEWVEAPPP---------LAADNVTKKEPPQ---RDDWMTSESLLLKTFS----RERKEPAKPN 179
            |||||||.|.         ...|..:.|:..|   ||:|||.:.:.:||.|    :..||..:..
Human   116 EDEWVEAVPSQTPDKEKAWKVKDEKSGKDDTQIIKRDEWMTVDFMSVKTVSSSSLKAEKETMRKI 180

  Fly   180 EKAQQIDAYDPAK-SGRELNPYWKSNGTGLP---------------------------------- 209
            |: ::..|.:.:| ..||||||||..|||||
Human   181 EQ-EKNQALEQSKLMERELNPYWKDGGTGLPPEDCSVSSITKVSVVEDGGLSWLRKSYLRMKEQA 244

  Fly   210 ----------------------------------------------------------------- 209

Human   245 EKQSRNFEDIVAERYGSMEIFQSKLEDAEKAASTKEDYRRERWRKPTYSDKAQNCQESRESDLVK 309

  Fly   210 ---------------------------------------------------------GFQKPQDD 217
                                                                     .|.:|.||
Human   310 YGNSSRDRYATTDTAKNSNNEKFIGDEKDKRPGSLETCRRESNPRQNQEFSFGNLRAKFLRPSDD 374

  Fly   218 DE-------RQAKPHSSSS---AQGS-SRGWRKP----------GAKAPSPPRRSRSRSKSATSS 261
            :|       |:.:|.||||   |||| ..|:|||          .:::.....:..|..|.:.:|
Human   375 EELSFHSKGRKFEPLSSSSALVAQGSLCSGFRKPTKNSEERLTSWSRSDGRGDKKHSNQKPSETS 439

  Fly   262 DEEEEEAVQQP--KSRPSCLTD-----------------------------EQINELAGKAIKAE 295
            .:|.:...:.|  ||:...|.|                             ::.|:|..|.||||
Human   440 TDEHQHVPEDPREKSQDEVLRDDPPKKEHLRDTKSTFAGSPERESIHILSVDEKNKLGAKIIKAE 504

  Fly   296 LKGKKELAAELNQQLEAARKERAEFIASGESVRNANTRPAKSKASAEHVLLTKVDQSGNVRPLVQ 360
            :.|..|||.:|..|||.|.|.:       |::.....:........:.|:|.:.||||.|.|:..
Human   505 MMGNMELAEQLKVQLEKANKFK-------ETITQIPKKSGVENEDQQEVILVRTDQSGRVWPVNT 562

  Fly   361 SGDPNESYGGRMGPKRGSKKVDTHVDGQRVRYFADDDRYDIKQMFEREKHATAAEVNLQYADIVS 425
            .|...||.|||    |..:.|.||.:.:|||||.|||...:..:.:.||..||...|..:..:.|
Human   563 PGKSLESQGGR----RKRQMVSTHEERERVRYFHDDDNLSLNDLVKNEKMGTAENQNKLFMRMAS 623

  Fly   426 KHKNPND----DLDDIFADKVRKQISASDAEKREMQSAIREHEKLVATLDNCERCFDSAKLDKQL 486
            |.....|    .|||:|..|..::....:.|:.:.:.||.||..|.|.::.|..||||::..|.|
Human   624 KFMGKTDGDYYTLDDMFVSKAAERERLGEEEENQRKKAIAEHRSLAAQMEKCLYCFDSSQFPKHL 688

  Fly   487 LVSLGDKIYLSLPWYMGLQSGHCILTTLQHVPCCTQLDEDAWEEISNFRKALTRMFAARRQDVVF 551
            :|::|.|:||.||....|..|||::..|||....|.||||.||||..|||:|.:||..:..|.:|
Human   689 IVAIGVKVYLCLPNVRSLTEGHCLIVPLQHHRAATLLDEDIWEEIQMFRKSLVKMFEDKGLDCIF 753

  Fly   552 YEIANKLHRRPHLSVHCIPIPASQGEMAPFYFKKAIEESEQEWCINKQLVSLRQKSLRAAIPKGL 616
            .|....:.::.|:...|||:|...|:|||.||||||.||::||.:||:|:.|..|.:|.::|:||
Human   754 LETNMSMKKQYHMVYECIPLPKEVGDMAPIYFKKAIMESDEEWSMNKKLIDLSSKDIRKSVPRGL 818

  Fly   617 PYVWVHFGMDSGFAHVIEDEDRFPANFAQEILGGMLELNPNAWRKPRKEA--NPIGKVKSFAENW 679
            ||..|.||:..||||||||:.:||..|.:||:||||::.|..|||..:|:  :...|...||:.|
Human   819 PYFSVDFGLHGGFAHVIEDQHKFPHYFGKEIIGGMLDIEPRLWRKGIRESFEDQRKKALQFAQWW 883

  Fly   680 KKFDCTQN 687
            |.:|.|::
Human   884 KPYDFTKS 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9213	NP_001285277.1	CwfJ_C_1	460..584	CDD:282524	54/123 (44%)
CG9213	NP_001285277.1	CwfJ_C_2	593..685	CDD:282523	44/93 (47%)
CWF19L2	NP_689647.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..147		50/160 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..483		28/212 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..583		9/25 (36%)
		HIT_like	662..786	CDD:412239	54/123 (44%)
		CwfJ_C_2	795..889	CDD:398381	44/93 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158982
Domainoid	1	1.000	121	1.000	Domainoid score	I5725
eggNOG	1	0.900	-	-		E1_KOG2477
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12366
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2412
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1407830at2759
OrthoFinder	1	1.000	-	-		FOG0003997
OrthoInspector	1	1.000	-	-		oto88587
orthoMCL	1	0.900	-	-		OOG6_103311
Panther	1	1.100	-	-	LDO	PTHR12072
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R275
SonicParanoid	1	1.000	-	-		X2761
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790