Protein Alignment HPN and CG18735

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_652645.1
• Gene: CG18735 / 59137
• FlyBaseID: FBgn0042098
• Length: 364
• Species: Drosophila melanogaster
• Alignment Length: 282
• Identity: 95/282 - (33%)
• Similarity: 137/282 - (48%)
• Gaps: 41/282 - (14%)

Human   150 CQDCGRRKLPV-DRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHC--------- 204
            |.:|....:.. .|||||::|.:..:||.:.|.:.|...||.||::..:.||||||
  Fly    69 CAECSCGNINTRHRIVGGQETEVHEYPWMIMLMWFGNFYCGASLVNDQYALTAAHCVNGFYHRLI 133

Human   205 ---FPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSP 266
               ..|.||..|..::            :...|..|:.|..|      ::....:||||:..:.|
  Fly   134 TVRLLEHNRQDSHVKI------------VDRRVSRVLIHPKY------STRNFDSDIALIRFNEP 180

Human   267 LPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQ 331
            :.|...:.|||:|...:... |:...|||||.....|..:..|||..|||:|.:.|..:::..::
  Fly   181 VRLGIDMHPVCMPTPSENYA-GQTAVVTGWGALSEGGPISDTLQEVEVPILSQEECRNSNYGESK 244

Human   332 IKPKMFCAGYPE-GGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSD 395
            |...|.||||.| ||.|:||||||||.   ..:.....::|.||||||.|||....|||||:|..
  Fly   245 ITDNMICAGYVEQGGKDSCQGDSGGPM---HVLGSGDAYQLAGIVSWGEGCAKPNAPGVYTRVGS 306

Human   396 FREWIFQAIK-----THSEASG 412
            |.:||.:..:     ...||:|
  Fly   307 FNDWIAENTRDACSCAQPEAAG 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	2/8 (25%)
		Tryp_SPc	163..400	CDD:238113	87/249 (35%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	89/252 (35%)