Protein Alignment HPN and CG11313

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_651821.3
• Gene: CG11313 / 43646
• FlyBaseID: FBgn0039798
• Length: 370
• Species: Drosophila melanogaster
• Alignment Length: 286
• Identity: 89/286 - (31%)
• Similarity: 126/286 - (44%)
• Gaps: 56/286 - (19%)

Human   153 CGRRKLPVDRIVGGRDTSLGRWPWQVSLRY---DGAHL---CGGSLLSGDWVLTAAHCFPERNR- 210
            || ..:..::|..|.:|.|..:.|.|.|.|   ||..|   |.|||::..:|:|||||.....|
  Fly   107 CG-GDIAYNQITKGNETVLTEFAWMVLLEYRPHDGQQLRTYCAGSLINNRYVVTAAHCVSAATRA 170

Human   211 ----VLSRWRVFAG-----AV-----AQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALV 261
                |..|..|..|     ||     .:..|..:|:.|:.:..|..:      .:....|||||:
  Fly   171 RKGDVSFRVSVRLGEHNTSAVVDCLNGRCLPEPVQIAVEEIRIHESF------GTRLFWNDIALI 229

Human   262 HLSSPLPLTEYIQPVCLPA--------AGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIIS 318
            .|:..:..:..|:|||||:        :|||.      ||.|||.| ...:.:.|..:.||..:.
  Fly   230 RLAREVAYSPSIRPVCLPSTVGLQNWQSGQAF------TVAGWGRT-LTSESSPVKMKLRVTYVE 287

Human   319 NDVCNGADFYGN--QIKPKMFCA-GYPEGGIDACQGDSGGPFVC-EDSISRTPRWRLCGIVSWGT 379
            ..:|...  |.:  .:.....|| |...|  |:|.||||||.:. .:.:     |.|.||||:|.
  Fly   288 PGLCRRK--YASIVVLGDSHLCAEGRSRG--DSCDGDSGGPLMAFHEGV-----WVLGGIVSFGL 343

Human   380 GCALAQKPGVYTKVSDFREWIFQAIK 405
            .|.....|.|||.|..:..||.|.|:
  Fly   344 NCGSRFWPAVYTNVLSYETWITQNIR 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	2/5 (40%)
		Tryp_SPc	163..400	CDD:238113	83/269 (31%)
CG11313	NP_651821.3	CLIP	24..78	CDD:463440
		Tryp_SPc	116..367	CDD:238113	85/272 (31%)