Protein Alignment HPN and CG9737

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_651783.1
• Gene: CG9737 / 43600
• FlyBaseID: FBgn0039758
• Length: 424
• Species: Drosophila melanogaster
• Alignment Length: 408
• Identity: 108/408 - (26%)
• Similarity: 174/408 - (42%)
• Gaps: 82/408 - (20%)

Human    54 VQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGT--SG 116
            ::||...|.|.|.:.|                 .|..|::.||:.: ..|::.:.:.|.|:  |.
  Fly    40 LEVSRCKAYLQVRNAT-----------------NLPAEKVNFLKKV-QCEVEQQVSEAQGSYESL 86

Human   117 FFCVDEGRLPHTQRLLEVISVCDCPRGRFLAA-----------------------ICQDCGRRKL 158
            ..|...|:    ..|..|:........|||..                       :..:||  |.
  Fly    87 VCCPANGQ----DYLFPVLQFSKFEYRRFLDVTARFKRKKLKRRIQTVEPSSGFNLLNECG--KQ 145

Human   159 PVDRIVGGRDTSLGRWPWQVSLRYD-GAHLCGGSLLSGDWVLTAAHCFP---ERNRV------LS 213
            ..:||.||....|..:||...|.|: ..:.|.|:|:....:||||||..   .|:|.      |.
  Fly   146 VTNRIYGGEIAELDEFPWLALLVYNSNDYGCSGALIDDRHILTAAHCVQGEGVRDRQGLKHVRLG 210

Human   214 RWRVFAGAVAQASPH-------GLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTE 271
            .:.|.........|:       .|.:..:.:..|..|..|    |....||||::.|..|:..|.
  Fly   211 EFNVKTEPDCIEEPNYLSCADAALDIAYEKIHVHPEYKEF----SNYKYNDIAIIRLKHPVSFTH 271

Human   272 YIQPVCLPAAGQ--ALVDGKICTVTGWGNTQYYGQ-----QAGVLQEARVPIISNDVCNG-ADFY 328
            ::.|:|||...:  .|.:|::.:|:|||.|..:.:     .:.:..:.|:|.:||:.|.. .:.:
  Fly   272 FVMPICLPNKSEPLTLAEGQMFSVSGWGRTDLFNKYFINIHSPIKLKLRIPYVSNENCTKILEGF 336

Human   329 GNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWG-TGCALAQKPGVYTK 392
            |.::.||..||| .|...|.|.||||||.:..|  .:..||...|:||:| |.|.:|.||.|||.
  Fly   337 GVRLGPKQICAG-GEFAKDTCAGDSGGPLMYFD--RQHSRWVAYGVVSYGFTQCGMAGKPAVYTN 398

Human   393 VSDFREWIFQAIKTHSEA 410
            |:::.:||...::...::
  Fly   399 VAEYTDWIDSVVQQRKKS 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	24/129 (19%)
		Tryp_SPc	163..400	CDD:238113	81/262 (31%)
CG9737	NP_651783.1	CLIP	28..89	CDD:463440	14/66 (21%)
		Tryp_SPc	149..406	CDD:214473	82/263 (31%)