Protein Alignment HPN and Jon99Ci

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_524555.1
• Gene: Jon99Ci / 43545
• FlyBaseID: FBgn0003358
• Length: 272
• Species: Drosophila melanogaster
• Alignment Length: 341
• Identity: 88/341 - (25%)
• Similarity: 127/341 - (37%)
• Gaps: 111/341 - (32%)

Human    88 LSCEEMGFLRALT--HS-----ELDVRTAGANG--TSGFFCVDEGRLPHTQRLLEVISVCDCPRG 143
            ||...:|...|||  ||     :|::|..|..|  |:|.. ..||::|:
  Fly     7 LSLAFLGVCSALTVPHSLVHPRDLEIRHGGIEGRITNGNL-ASEGQVPY---------------- 54

Human   144 RFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPER 208
                               |||....|.|.|.|           ||||::...||||||||....
  Fly    55 -------------------IVGVSLNSNGNWWW-----------CGGSIIGHTWVLTAAHCTAGA 89

Human   209 NRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEEN----------SNDIALVHL 263
            :..    .::.|||....|                 .||...|.||          .:|:||:
  Fly    90 DEA----SLYYGAVNYNEP-----------------AFRHTVSSENFIRYPHYVGLDHDLALI-- 131

Human   264 SSP-LPLTEYIQPVCLPAAGQAL--VDGKICTVTGWGNTQYYGQQAGVLQEARV---PIISNDVC 322
            .:| :.....:..:.||:.....  .:.......||| ..|.|  :.|:::.||   .:||...|
  Fly   132 KTPHVDFYSLVNKIELPSLDDRYNSYENNWVQAAGWG-AIYDG--SNVVEDLRVVDLKVISVAEC 193

Human   323 NGADFYG-NQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSW--GTGCALA 384
            ..  :|| :.......|...|:|.. .||||||||.|.::..      :|.||.|:  ..||.:.
  Fly   194 QA--YYGTDTASENTICVETPDGKA-TCQGDSGGPLVTKEGD------KLIGITSFVSAYGCQVG 249

Human   385 QKPGVYTKVSDFREWI 400
             .|..:|:|:.:.|||
  Fly   250 -GPAGFTRVTKYLEWI 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	17/79 (22%)
		Tryp_SPc	163..400	CDD:238113	69/255 (27%)
Jon99Ci	NP_524555.1	Tryp_SPc	41..266	CDD:238113	76/307 (25%)