DRSC/TRiP Functional Genomics Resources

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Protein Alignment HPN and Jon99Ciii

DIOPT Version :10

Sequence 1:NP_002142.1 Gene:HPN / 3249 HGNCID:5155 Length:417 Species:Homo sapiens
Sequence 2:NP_733330.1 Gene:Jon99Ciii / 43543 FlyBaseID:FBgn0003357 Length:265 Species:Drosophila melanogaster


Alignment Length:250 Identity:76/250 - (30%)
Similarity:108/250 - (43%) Gaps:38/250 - (15%)


- Green bases have known domain annotations that are detailed below.


Human   162 RIVGGRDTSLGRWPWQVSLRY--DGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQ 224
            ||..|.....|:.|:.|.|.:  :|...||||::...||||||||....:.|...:    ||..:
  Fly    35 RITNGYPAYEGKVPYIVGLLFSGNGNWWCGGSIIGNTWVLTAAHCTNGASGVTINY----GASIR 95

Human   225 ASPHGLQ-LGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEY---IQPVCLPAAGQAL 285
            ..|.... :|...::.|..|      ||....|||:|:.    .|..::   :..|.||:.....
  Fly    96 TQPQYTHWVGSGDIIQHHHY------NSGNLHNDISLIR----TPHVDFWSLVNKVELPSYNDRY 150

Human   286 VD--GKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGA-DFYGNQIKPKMFCAGYPEGGID 347
            .|  |.....:|||.|.........||...|.|||...|:.. ..:.|     |.|.. .:||..
  Fly   151 QDYAGWWAVASGWGGTYDGSPLPDWLQSVDVQIISQSDCSRTWSLHDN-----MICIN-TDGGKS 209

Human   348 ACQGDSGGPFVCEDSISRTPRWRLCGIVSWGT--GCALAQKPGVYTKVSDFREWI 400
            .|.||||||.|..|..      ||.|:.|:|:  ||. :..|.|:::|:.:.:||
  Fly   210 TCGGDSGGPLVTHDGN------RLVGVTSFGSAAGCQ-SGAPAVFSRVTGYLDWI 257

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HPNNP_002142.1 Hepsin-SRCR 51..159 CDD:462736
Tryp_SPc 163..400 CDD:238113 73/247 (30%)
Jon99CiiiNP_733330.1 Tryp_SPc 36..260 CDD:238113 74/248 (30%)
Blue background indicates that the domain is not in the aligned region.

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