Protein Alignment HPN and CG11843

DIOPT Version :10

• Sequence 1: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_651663.1
• Gene: CG11843 / 43432
• FlyBaseID: FBgn0039630
• Length: 316
• Species: Drosophila melanogaster
• Alignment Length: 296
• Identity: 86/296 - (29%)
• Similarity: 115/296 - (38%)
• Gaps: 59/296 - (19%)

Human   141 PRGRFLAAICQDCGRRKLPVDRIVGGRDTS---------LGRWPWQVSLRYDGAHLCGGSLLSGD 196
            |.....:.|..:| |...|:  ||||....         |||.| ..|.|.|  ..|||.|:|..
  Fly    49 PGASIESRIIDNC-RSYTPL--IVGGHPAQPREFPHMARLGRRP-DPSSRAD--WFCGGVLISER 107

Human   197 WVLTAAHCFPERNRVLSRWRV----FAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSND 257
            :|||||||.......::..|:    |......|:|....  |...:.|.||   .||   :..:|
  Fly   108 FVLTAAHCLESERGEVNVVRLGELDFDSLDEDAAPRDYM--VAGYIAHPGY---EDP---QFYHD 164

Human   258 IALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVC 322
            |.||.|:..:....|..|.|||...:...|..|  ..|||:|....:.:..|.:.::....|.||
  Fly   165 IGLVKLTEAVVFDLYKHPACLPFQDERSSDSFI--AVGWGSTGLALKPSAQLLKVKLQRYGNWVC 227

Human   323 N----------GADFYGNQIKPKMFCAGYPEGGIDACQGDSGGP-------FVCEDSISRTPRWR 370
            .          ...|.||    ...|.| .|...|.|.||||||       :.|        .:.
  Fly   228 KKLLTRQVEEFPRGFDGN----NQLCVG-SEMAQDTCNGDSGGPLLMYHREYPC--------MYV 279

Human   371 LCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKT 406
            :.||.|.|..|.....||:||:|..:..||.:.:.|
  Fly   280 VVGITSAGLSCGSPGIPGIYTRVYPYLGWIARTLAT 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	4/17 (24%)
		Tryp_SPc	163..400	CDD:238113	78/266 (29%)
CG11843	NP_651663.1	Tryp_SPc	68..312	CDD:238113	80/269 (30%)